DOI Prefix : 10.9780 | Journal DOI : 10.9780/22307850
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Volume : III, Issue : XI, December - 2013

Synthesis And Antimicrobial Evaluation Of Some New N-(2,4 Dichlorobenzyl)- Indolylchalcones From 1h-indolyl-3 phenylpropenones

Imtiyaz A. Khana , Firdous G. Khan a, R. Minhaaj b

DOI : 10.9780/22307850, Published By : Laxmi Book Publication

Abstract :

Series of new 1-{N-(2,4-dichlorobenzyl)indolyl)}-3-phenylpropanones were synthesized. The intermediate 1H-indolyl-3-phenylpropenones were synthesized by the reaction of indole-3-carboxaldehyde with appropriate acetophenone in the presence of piperidine under reflux condition. Thus, the prepared intermediate indolyl chalcones has been subsequently treated with 2,4-dichlorobenzyl chloride in the presence of potassium carbonate and DMF as solvent under reflux condition to afford title compounds in good yield. The structures of intermediate and newly synthesized N-(2,4 dichlorobenzyl)- indolylchalcones were confirmed by physical and spectral analysis. All the N-(2,4 dichlorobenzyl)- indolylchalcones were evaluated for antibacterial and antifungal activities. Selected N-(2,4 dichlorobenzyl)- indolylchalcones showed good to excellent antibacterial and antifungal activities with reference to the well-established standards.

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Cite This Article :

Imtiyaz A. Khana , Firdous G. Khan a, R. Minhaaj b, (2013). Synthesis And Antimicrobial Evaluation Of Some New N-(2,4 Dichlorobenzyl)- Indolylchalcones From 1h-indolyl-3 phenylpropenones. Indian Streams Research Journal, Vol. III, Issue. XI, DOI : 10.9780/22307850, http://oldisrj.lbp.world/UploadedData/3419.pdf

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