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Volume : III, Issue : X, November - 2013 Synthesis, Antibactrial Activity And Carcinogenicity Study Of 1, 4 – disubsubstituted 1, 2, 3- Bistriazoles Via Click Chemistry Sachin P. Shirame, Sharvan Y. Jadhav And Raghunath B. Bhosale DOI : 10.9780/22307850, Published By : Laxmi Book Publication Abstract : A series of bistriazole derivatives 4a-i was prepared by the treatment of 1, 3 dibromopropane with sodium azide, sodium carbonate, ascorbic acid and substituted alkynes, respectively. The title compounds bistriazole derivatives shown good yields and high purity. All the synthesized compounds were characterized by IR, 1H NMR, and Mass spectroscopy and these molecules were evaluated in vitro for their antibacterial activity and carcinogenicity study. Keywords : Article : Cite This Article : Sachin P. Shirame, Sharvan Y. Jadhav And Raghunath B. Bhosale, (2013). Synthesis, Antibactrial Activity And Carcinogenicity Study Of 1, 4 – disubsubstituted 1, 2, 3- Bistriazoles Via Click Chemistry. Indian Streams Research Journal, Vol. III, Issue. X, DOI : 10.9780/22307850, http://oldisrj.lbp.world/UploadedData/3289.pdf References : - Wahe H, Asobo PF, Chekasov RA, Fomum ZT, Doepp D. Heterocycles of biological importance: Part 8.1. Formation of pyrimido [1,2-a] benzimidazoles and oxazolo[3,2-a]benzimidazoles by conjugate addition of 2-aminobenzimidazoles to 4-hydroxy-2-alkynenitriles. ARKIVOC. (2004); (i):130–137 .
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