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Volume : III, Issue : IV, May - 2013 SEQUENCE ANALYSIS AND HOMOLOGY MODELING OF SHANK3 PROTEIN INVOLVED IN AUTISM SHAMA N. MUJAWAR , VAIBHAV V. KANDALE AND PREETI J. WELASLY Published By : Laxmi Book Publication Abstract : Autism is a disorder of neural development characterized by impaired social
interaction and communication, and by restricted and repetitive behavior. Autism affects
information processing in the brain by altering how nerve cells and their synapses
connect and organize. Mutations in Shank3 gene are a cause of autism spectrum disorder
(ASD). SH3 and multiple ankyrin repeat domains 3 (Shank3), also known as proline-rich
synapse-associated protein 2 (ProSAP2), is a protein that in humans is encoded by the
SHANK3 gene on chromosome 22q13.3.Primary sequence analysis was done by using
ExPASy'sProtparam. Secondary structure was predicted using GOR4, SOPMA and
CFSSP. Homology modeling of Shank3 (Homo sapiens) protein was done by using
different tools and servers i.e. ESyPred3D, SWISS-MODEL server, EasyModeller and
Phyre2 and the four different structure were validated using Procheck. The project work
aims to build a potential model of shank3 protein which can be used for drug designing. Keywords : Article : Cite This Article : SHAMA N. MUJAWAR , VAIBHAV V. KANDALE AND PREETI J. WELASLY, (2013). SEQUENCE ANALYSIS AND HOMOLOGY MODELING OF SHANK3 PROTEIN INVOLVED IN AUTISM. Indian Streams Research Journal, Vol. III, Issue. IV, http://oldisrj.lbp.world/UploadedData/2345.pdf References : - Newschaffer CJ, Croen LA, Daniels J et al.the epidemiology of autism spectrum disorders 2007;
- Stefanatos GA. Regression in autistic spectrum disorders. Neuropsychol Rev. 2008;
- World Health Organization. F84. Pervasive developmental disorders; 2007
- Rogers SJ. What are infant siblings teaching us about autism in infancy?Autism Res. 2009;
- Autism and Developmental Disabilities Monitoring Network Surveillance Year 2002 Principal Investigators; Centers for Disease Control and Prevention. Prevalence of autism spectrum disorders-- autism and developmental disabilities monitoring network, 14 sites, United States, 2002. MMWR SurveillSumm. 2007 Feb 9; 56(1):12-28.
- SOPMA: .ComputApplBiosci (1995) Dec; 11(6):681-684 Geourjon C, Deleage G Institut de Biologie ET de Chimie des Proteines, UPR 412-CNRS, Lyon, France.
- Arnold K., Bordoli L., Kopp J., and Schwede T. (2006). The SWISS-MODEL Workspace: Bioinformatics, 22,195-201.
- Bertoglio K, Hendren RL. New developments in autism. PsychiatrClin North Am. 2009; 32:1-14.
- National Autistic Society. Diagnosis: how can it benefit me as an adult? 2005 [cited 2008-03-24].
- Bozdagi O, Sakurai T, Papapetrou D, Wang X, Dickstein DL, Takahashi N, Kajiwara Y, Yang M, Katz AM, Scattoni ML, Harris MJ, Saxena R, Silverman JL, Crawley JN, Zhou Q, Hof PR, Buxbaum JD (2010). "Haploinsufficiency of the autism-associated Shank3 gene leads to deficits in synaptic function, social interaction, and social communication". Mol Autism1 (1): 15. Doi: 10.1186/2040-2392-1-15. PMC 3019144. PMID 2116702
- "Entrez Gene: SHANK3 SH3 and multiple ankyrin repeat domains 3”
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