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Volume : III, Issue : III, April - 2013

PROMISES OF INDUCED PLURIPOTENT STEM CELLS IN A THERAPEUTIC CONTEXT

HIMANSU KUMAR AND C.V.S.SIVA PRASAD

Published By : Laxmi Book Publication

Abstract :

Transformation of somatic cells into induced pluripotent stem cells (IPSC) has opened a new page in the clinical world. In 2006, Yamanaka and Takahashi have shown that the four reprogramming factors namely OCT4, NANOG, SOX2, and LIN28 are sufficient for the reprogramming of somatic cells into IPSC. Fortunately these IPSC are containing all essential features of embryonic stem cells and finally it leads to specific tissue regeneration. Although there are certain limitations of IPSC like low efficiency of IPSC generation, reprogramming process is highly time consuming and viral vector based delivery of transcription factors into target may induce mutations in the genome. In this review we would like to focus on comprehensive knowledge about IPSC, derivation mechanism of IPSC, clinical application of IPSC and technical challenges for the implementation of the IPSC into biomedical and therapeutic applications.

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HIMANSU KUMAR AND C.V.S.SIVA PRASAD, (2013). PROMISES OF INDUCED PLURIPOTENT STEM CELLS IN A THERAPEUTIC CONTEXT. Indian Streams Research Journal, Vol. III, Issue. III, http://oldisrj.lbp.world/UploadedData/2290.pdf

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