Volume : II, Issue : V, June - 2012 Antihyperlipidaemic Activities Of Eclipta Alba And Boerhaavia Diffusa In Rats And Their Comparison With Atorvastatin.Amod Kumar Sachan,Rajendra Nath and Rakesh Kumar Dixit , Shailendra Dwivedi, Kamlesh Kumar Pant, Rakesh Chandra Verma Published By : Laxmi Book Publication Abstract : Antihyperlipidaemic activities of ethanolic extracts of Eclipta alba (EA) and Boerhaavia diffusa (BD)
in adult Wistar rats of both sexes, weighing 140-150 g were studied and compared with those of
Atorvastatin. Rats were given high fat diet (HFD) for 49 days to produce hyperlipidaemia. Then drugs were
given for 45 days without stopping HFD. Rats on atorvastatin (80 mg/kg) showed most significant
improvement (55.46, 57.76 and 66.50% decrease in mean total cholesterol, triglyceride and LDL
respectively; 28.37% increase in mean HDL). Keywords : Article : Cite This Article : Amod Kumar Sachan,Rajendra Nath and Rakesh Kumar Dixit , Shailendra Dwivedi, Kamlesh Kumar Pant, Rakesh Chandra Verma, (2012). Antihyperlipidaemic Activities Of Eclipta Alba And Boerhaavia Diffusa In Rats And Their Comparison With Atorvastatin.. Indian Streams Research Journal, Vol. II, Issue. V, http://oldisrj.lbp.world/UploadedData/1033.pdf References : - American heart association, 2001. Heart and Stroke Statistical Update. Dallas, Texas.
- Larosa J.C., D., Hunninghake, D., Bush, 1990. The task force on cholesterol issue. American Heart Association, Circulation, 81: 1721-33.
- Chopra RN, Nayar SL, Chopra IC: Glossary of Indian Medicinal plants. C.S.I.R., New Delhi. 1955.
- Kritikar KR, Basu BD: Chronica Botanica Indian Medicinal plants. New Delhi. 1975.
- Wagner H , Geyer B , Yoshinobu K , Govind S R : Coumestansasthe main active principles of the liver drugs Eclipta alba and wedelia calendulacea. Planta Med 1986; 5:370-4.
- Saxena AK, Singh B, Anand KK: Hepatoprotective effects of Eclipta alba on subcellular levels in rats. J Ethnopharmacol 1993; 40(3):155-61.
- CSIR, The Wealth of India: Raw Materials. Vol. VII B. CSIR, New Delhi, India. 1988; p. 174.
- Cruz GL: Dicionario Das Plantas Uteis Do Brasil. Bertrand, Rio de Janeiro, Brazil, 5th Edition 1995.
- Mudgal V: Studies on medicinal properties of Convolvulus pluricaulis and Boerhaavia diffusa. Planta Medica 1975; 28:62–68.
- Dhandapani R., 2007. Hypolipidemic activity of Eclipta prostrata (L.) L. leaf extract in atherogenic diet induced hyperlipidemic rats. Indian Journal of Experimental biology, 45: 617-19.
- Rangineni V., D., Sharada, S., Saxena, 2007. Diuretic, Hypotensive, and Hypocholesterolemic Effects of Eclipta alba in Mild Hypertensive Subjects: A Pilot Study. J Med Food, 10 (1):143–148.
- Pari L., M.A., Satheesh, 2004. Antidiabetic Effect of Boerhavia diffusa: Effect on Serum and Tissue Lipids in Experimental Diabetes. Journal of Medicinal Food. Winter, 7(4): 472-476.
- Mouzeyan A., J., Choi, H., Allayee, X., Wang, J., Sinsheimer, J., Phan, L.W.,Castellani, K., Reue, A.J., Lusis, R.C., Davis, 2000. A locus conferring resistance to diet induced hypercholesterolemia and atherosclerosis on mouse chromosome 2. J Lipid Res, 41(4):573-82.
- Wang X., P., Gargalovic, J., Wong, J.L., Gu, X., Wu, H., Qi, P., Wen, L., Xi, B., Tan, R., Gogliotti, L.W., Castellani, A., Chatterjee, A.J., Lusis, 2004. Hyplip2, a gene for combined hyperlipidaemia and increased atherosclerosis. Arterioscler Thromb Vasc Biol,.24(10):1928-34.
- Dobrian A.D., M.J., Davies, R.L., Prewitt, T.J., Lauterio, 2000. Development of Hypertension in a Rat Model of Diet-Induced Obesity. Hypertension. 35:1009-1015.
- Rajyalakshmi G., A., Reddy, V. V., Rajesham, 2009. A Comparative Antihyperlipidemic Activity Of Atorvastatin With Simvastatin In Rats. The Internet Journal of Pharmacology, Vol. 6- Number 2.
- Heeba G., M., Abd-Elghany, 2010. Effect of combined administration of ginger (Zingiber officinale Roscoe) and atorvastatin on the liver of rats. Phytomed, 17:14;1076-81.
- Dhandapani R., 2007. Hypolipidemic activity of Eclipta prostrata (L.) L. leaf extract in atherogenic diet induced hyperlipidemic rats. Indian Journal of Experimental biology, 45: 617-19.
- Pari L., M.A., Satheesh, 2004. Antidiabetic Effect of Boerhavia diffusa: Effect on Serum and Tissue Lipids in Experimental Diabetes. Journal of Medicinal Food. Winter, 7(4): 472-476.
- Hulley S.B., R.H., Rosenman, R.D., Bawol, R.J., Brand, 1980. Epidemiology as guide to clinical decision – The association between triglyceride & coronary heart disease. N. Eng. J. Med., 302: 1383 – 1389.
- Upadhaya V.P., K., Pandey, 1984. J S (Ed.) Interprint , New Delhi , India, 375-377.
- Pfizer Labs, a division of Pfizer inc., New York.
- Rao K.N., K.M., Boini , S., Nammi, 2004. Effect of chronic administration of Boerhaavia diffusa Linn. leaf extract on experimental diabetes in rats. Tropical Journal of Pharmaceutical Research, 3 (1): 305-309.
- Saxena A.K., B., Singh, K.K., Anand, 1993. Hepatoprotective effects of Eclipta alba on subcellular levels in rats. J Ethnopharmacol, 40(3):155-61.
- Patel M.B., S.J., Panchal, J.A., Patel, 2009. Antianaphylactic activity of alcoholic extract of Eclipta alba. journal of young pharmacists, 1(3) : 244-250.
- Orisakwe O.E., O.J., Afonne, M.A., Chude, E., Obi, C.E., Dioka, 2003. Subchronic toxicity studies of aqueous extract of Boerhaavia diffusa leaves. J of Health Sciences, 49(6): 444-447.
- Hiruma-Lima C.A., J.S., Gracioso , E.J., Bighetti, R.L., Germonsén , A.R., Souza Brito, 2000. The juice of fresh leaves of Boerhaavia diffusa L. (Nyctaginaceae) markedly reduces pain in mice. J Ethnopharmacol, 71 (12):267-74.
- Kritchevsky S.B., 1999. â -Carotene, carotenoids and the prevention on coronary heart disease. J Nutr, 129: 5–8.
- Hillgreen.com : http://www.hillgreen.com/herbs c13 e3.html.
|
Article Post Production
Article Indexed In
|