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Volume : IV, Issue : III, April - 2014

EV ALUA TION OF ANTIDEPRESSANT ACTIVITYIN CENTRALNERVOUS SYSTEM OFMICE MODEL USING AQUEOUS EXTRACTOF DIGERAMURICAT A

Sundar S. Mety, Liyakhat Ahmed MD Pratima Mathad

By : Laxmi Book Publication

Abstract :

The aim of the present study was to evaluate some effects of Digera muricata (DM) on central nervous system. The effects of Aqueous Extracts of Digera muricata (AEDM) tested with Neuropharmacological activities like acute toxicity , spontaneous motor activity , exploratory behavioral pattern, marble burying and tail suspension tests were studied in Albino mice. In acute toxicity mice were administered with AEDM and MEDM doses orally at 50, 100 and 200 mg/kg body weight intraperitoneally respectively , were tested in mice using different standards like 4 mg diazepam/kg, 3 mg chlorpromazine and 3 mg imipramin/kg -induced sleep test. The AEDM in dosages (150 mg/kg) was found to produce a profound increase in all the behavioral activity . It also showed a marked antidepressant effect as evidenced by a significant increase in all central nervous system behavioral experiments.

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    Cite This Article :

    Sundar S. Mety, Liyakhat Ahmed MD Pratima Mathad (2014). EV ALUA TION OF ANTIDEPRESSANT ACTIVITYIN CENTRALNERVOUS SYSTEM OFMICE MODEL USING AQUEOUS EXTRACTOF DIGERAMURICAT A. Indian Streams Research Journal, Vol. IV, Issue. III, http://isrj.org/UploadedData/4471.pdf

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    224. Kinjal Ch, Navin Sh, Vishavas R, Sachin P . 2011. Anticonvulsant activity of solasodine isolated from Solanum
    225. Mahendran S, Thippeswamy BS, V eerapur VP , Badami S. 2011. Anticonvulsant activity of embelin isolated from Embelia
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    272. Seetharam, Y . N., Kotresha, K. and Uploankar, S. B, (2000). Flora of Gulbarga District, Gulbarga University, Gulbarga. Pp.
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    278. Seetharam, Y . N., Kotresha, K. and Uploankar, S. B, (2000). Flora of Gulbarga District, Gulbarga University, Gulbarga. Pp.
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    280. Seetharam, Y . N., Kotresha, K. and Uploankar, S. B, (2000). Flora of Gulbarga District, Gulbarga University, Gulbarga. Pp.
    281. Mahendran S, Thippeswamy BS, V eerapur VP , Badami S. 2011. Anticonvulsant activity of embelin isolated from Embelia
    282. 27-31.
    283. Kinjal Ch, Navin Sh, Vishavas R, Sachin P . 2011. Anticonvulsant activity of solasodine isolated from Solanum
    284. Mahendran S, Thippeswamy BS, V eerapur VP , Badami S. 2011. Anticonvulsant activity of embelin isolated from Embelia
    285. In Alloxan induced diabetic rats. International Journal of Pharmaceutical Sciences and Research. 2(6): 1525-1529.
    286. Parrota, J. A. (2001). Healing plants of Peninsular India. CABI Publishing. Pp. 223-235.
    287. sisymbriifolium fruits in rodents. Pharmaceutical Biology, 49: 194-199
    288. In Alloxan induced diabetic rats. International Journal of Pharmaceutical Sciences and Research. 2(6): 1525-1529.
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    290. Kinjal Ch, Navin Sh, Vishavas R, Sachin P . 2011. Anticonvulsant activity of solasodine isolated from Solanum

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