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Volume : IV, Issue : I, February - 2014

DIMETHOATE INDUCED OXIDATIVE STRESS IN HEART ALBINO RAT

R. Penchalamma, Ramesh Babu. Kand and Jacob Doss. P

By : Laxmi Book Publication

Abstract :

Now days, peoples exposure to chemical compounds such as organphosphorous insecticide is continuously on the rise more and more. These compounds have induced an excessive production of free radicals which are responsible for several cell alterations in the organism. Recent investigations have proved the crucial role of nutritional antioxidants to prevent the damage caused by toxic compounds.Dimethoate (DM) is an organ phosphorous insecticide and acaricide used to kill mites and aphids among other insects and is applied on citrus, cotton, fruit, olives, potatoes, tea, tobacco and vegetables. The aim of the present work was to study biochemical changes that might occur in the heart of albino rats as a result of DM intoxication. In the present investigation the animals were treated with 1/10th of LD50of DM via oral gavage (34.5mg/kg body weight. The first group animals were considered as control animals. Second group of animals were treated with Dimethoate via oral gavage (34.5mg/kg body weight which is 1/10th of LD50) for 10 days, third and fourth groups of animals were administered for 20 and 30 days with an interval of 48h respectively. Total proteins showed decrement in the DM treated groups while all the other parameters selected in the present investigation showed an increment. The present findings indicate that chronic exposure to DM has clear toxic effect on the heart of albino rats.

Keywords :


Article :


Cite This Article :

R. Penchalamma, Ramesh Babu. Kand and Jacob Doss. P(2014). DIMETHOATE INDUCED OXIDATIVE STRESS IN HEART ALBINO RAT. Indian Streams Research Journal, Vol. IV, Issue. I, http://isrj.org/UploadedData/4211.pdf

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  69. FerahSayim, (2007) Dimethoate-induced biochemical and histopathological changes in the liver of rats. Experimental and
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  91. poising.J Toxicol Clin toxicol 33(3):257-60.
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  109. pharmacology, 37(3): 160-164.
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  117. Devi Srilakshmi Kala S, Umakanthi V, Jayasudha M, Malleswari M, RavikanthSV and Jacob Doss P,(2013). Effect of
  118. Banerjee BD, Seth V.Ahmad RS.(2001). Pesticide – induced oxidative stress: perspective and trands. Rev environ health
  119. Heudorf U, ButteW, Schulz C, Angerer J, (2006). Reference values for metabolites of pyrethroid and organophosphorus
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  125. study. Crit Care Med 21(11): 1706-11.
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  127. lesions, measurement and substrate specificity of DNA repair glycosylases. Biol Chem 383:93
  128. Manna, S, BhattacharyyaD, MandalTKand Das S, (2005). Reported dose toxicity of Deltamethrin in rats. Indian journal of
  129. pharmacology, 37(3): 160-164.
  130. De-Bleecker J, van-Den-Neucker K, Colradyn F, (1993).Intermediate syndromeinOrganophospharus poising: a prospective
  131. Manna, S, BhattacharyyaD, MandalTKand Das S, (2005). Reported dose toxicity of Deltamethrin in rats. Indian journal of
  132. pharmacology, 37(3): 160-164.
  133. and brain of rats following subchronic exposure, Toxicology, 215: 2005b, p. 173-181.
  134. Cadet J, Bellon S, Berger M,Bourdat AG, Douki T,DuarteV, (2002). Recent aspects of oxidative DNA damage: guanine
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  136. De-Bleecker J, van-Den-Neucker K, Colradyn F, (1993).Intermediate syndromeinOrganophospharus poising: a prospective
  137. Sharma Y, BashirS,Irshad M, DattaguptaS,Dogra, TD, (2005b.). Dimethoate- induced effects on antioxidant status of liver
  138. poising.J Toxicol Clin toxicol 33(3):257-60.
  139. lesions, measurement and substrate specificity of DNA repair glycosylases. Biol Chem 383:93
  140. Halliwell B, Guteride JMC, Cross CE, (1992). Free radicals, antioxidants and human disease: where we now? J Lab Clin
  141. Halliwell B, Guteride JMC, Cross CE, (1992). Free radicals, antioxidants and human disease: where we now? J Lab Clin
  142. Cadet J, Bellon S, Berger M,Bourdat AG, Douki T,DuarteV, (2002). Recent aspects of oxidative DNA damage: guanine
  143. Beyer WE.Fridovich I.(1987). Assaying for SOD activity some large consequences of minor changes in conditions. 161 :
  144. Devi Srilakshmi Kala S, Umakanthi V, Jayasudha M, Malleswari M, RavikanthSV and Jacob Doss P,(2013). Effect of
  145. intoxication on rat pancreass. Toxicol Lett 133:161-70.
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  148. Goetz ME, Luch A, (2008).Reactive species: a cell damaging rout assisting to chemical carcinogens. Cancer Lett 266: 73-
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  151. and brain of rats following subchronic exposure, Toxicology, 215: 2005b, p. 173-181.
  152. Hagar HH, Fahmy AH, (2002). A biochemical, histochemical and ultrastructural evaluation of the effect of Dimethoate
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  158. Toxicologic Pathology 59:237-243.
  159. Goetz ME, Luch A, (2008).Reactive species: a cell damaging rout assisting to chemical carcinogens. Cancer Lett 266: 73-
  160. poising.J Toxicol Clin toxicol 33(3):257-60.
  161. lesions, measurement and substrate specificity of DNA repair glycosylases. Biol Chem 383:93
  162. Manna, S, BhattacharyyaD, MandalTKand Das S, (2005). Reported dose toxicity of Deltamethrin in rats. Indian journal of
  163. pharmacology, 37(3): 160-164.
  164. and brain of rats following subchronic exposure, Toxicology, 215: 2005b, p. 173-181.
  165. De-Bleecker J, van-Den-Neucker K, Colradyn F, (1993).Intermediate syndromeinOrganophospharus poising: a prospective
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  169. Halliwell B, Guteride JMC, Cross CE, (1992). Free radicals, antioxidants and human disease: where we now? J Lab Clin
  170. study. Crit Care Med 21(11): 1706-11.
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  172. pharmacology, 37(3): 160-164.
  173. and brain of rats following subchronic exposure, Toxicology, 215: 2005b, p. 173-181.
  174. Beyer WE.Fridovich I.(1987). Assaying for SOD activity some large consequences of minor changes in conditions. 161 :
  175. Devi Srilakshmi Kala S, Umakanthi V, Jayasudha M, Malleswari M, RavikanthSV and Jacob Doss P,(2013). Effect of
  176. De-Bleecker J, van-Den-Neucker K, Colradyn F, (1993).Intermediate syndromeinOrganophospharus poising: a prospective
  177. Beyer WE.Fridovich I.(1987). Assaying for SOD activity some large consequences of minor changes in conditions. 161 :
  178. Devi Srilakshmi Kala S, Umakanthi V, Jayasudha M, Malleswari M, RavikanthSV and Jacob Doss P,(2013). Effect of
  179. 559-66
  180. insecticides in urine for human bio monitoring in environmental medicine. Int J Hyg Environ Health, 209: 293-9.
  181. FerahSayim, (2007) Dimethoate-induced biochemical and histopathological changes in the liver of rats. Experimental and
  182. Med 119:598-620
  183. Dimethoateon different regions of thebrain inAlbino rat. (In Press)
  184. De-Bleecker J, van-Den-Neucker K, Colradyn F, (1993).Intermediate syndromeinOrganophospharus poising: a prospective
  185. Toxicologic Pathology 59:237-243.
  186. intoxication on rat pancreass. Toxicol Lett 133:161-70.
  187. Beyer WE.Fridovich I.(1987). Assaying for SOD activity some large consequences of minor changes in conditions. 161 :
  188. Devi Srilakshmi Kala S, Umakanthi V, Jayasudha M, Malleswari M, RavikanthSV and Jacob Doss P,(2013). Effect of
  189. Toxicologic Pathology 59:237-243.
  190. Goetz ME, Luch A, (2008).Reactive species: a cell damaging rout assisting to chemical carcinogens. Cancer Lett 266: 73-
  191. Toxicologic Pathology 59:237-243.
  192. Goetz ME, Luch A, (2008).Reactive species: a cell damaging rout assisting to chemical carcinogens. Cancer Lett 266: 73-
  193. 16:1.
  194. marker of oxidative stress. Nutr Metab Cardiovasc Dis 15:316-28.
  195. Aebi H, (1984). Catalase in vitro. Methods enzymol 105:121-6.
  196. Betrosian A, Balla M,Kafiri G,Kofinas G, Makri R,Kakouri A. (1995). Multiple systems organ failure from organophosphate
  197. Toxicologic Pathology 59:237-243.
  198. Goetz ME, Luch A, (2008).Reactive species: a cell damaging rout assisting to chemical carcinogens. Cancer Lett 266: 73-
  199. Cadet J, Bellon S, Berger M,Bourdat AG, Douki T,DuarteV, (2002). Recent aspects of oxidative DNA damage: guanine
  200. Beyer WE.Fridovich I.(1987). Assaying for SOD activity some large consequences of minor changes in conditions. 161 :
  201. Devi Srilakshmi Kala S, Umakanthi V, Jayasudha M, Malleswari M, RavikanthSV and Jacob Doss P,(2013). Effect of
  202. Betrosian A, Balla M,Kafiri G,Kofinas G, Makri R,Kakouri A. (1995). Multiple systems organ failure from organophosphate
  203. Fridovich I, Beachamp,(1995). Superoxide radical and superoxide dismutases. Annu.Rev.Biochem, 64-97.
  204. Banerjee BD, Seth V.Ahmad RS.(2001). Pesticide – induced oxidative stress: perspective and trands. Rev environ health
  205. Heudorf U, ButteW, Schulz C, Angerer J, (2006). Reference values for metabolites of pyrethroid and organophosphorus
  206. Fridovich I, Beachamp,(1995). Superoxide radical and superoxide dismutases. Annu.Rev.Biochem, 64-97.
  207. Beyer WE.Fridovich I.(1987). Assaying for SOD activity some large consequences of minor changes in conditions. 161 :
  208. Devi Srilakshmi Kala S, Umakanthi V, Jayasudha M, Malleswari M, RavikanthSV and Jacob Doss P,(2013). Effect of
  209. Cadet J, Bellon S, Berger M,Bourdat AG, Douki T,DuarteV, (2002). Recent aspects of oxidative DNA damage: guanine
  210. study. Crit Care Med 21(11): 1706-11.
  211. Aebi H, (1984). Catalase in vitro. Methods enzymol 105:121-6.
  212. Goetz ME, Luch A, (2008).Reactive species: a cell damaging rout assisting to chemical carcinogens. Cancer Lett 266: 73-
  213. 559-66
  214. insecticides in urine for human bio monitoring in environmental medicine. Int J Hyg Environ Health, 209: 293-9.
  215. Toxicologic Pathology 59:237-243.
  216. Goetz ME, Luch A, (2008).Reactive species: a cell damaging rout assisting to chemical carcinogens. Cancer Lett 266: 73-
  217. Toxicologic Pathology 59:237-243.
  218. Goetz ME, Luch A, (2008).Reactive species: a cell damaging rout assisting to chemical carcinogens. Cancer Lett 266: 73-
  219. 559-66
  220. insecticides in urine for human bio monitoring in environmental medicine. Int J Hyg Environ Health, 209: 293-9.
  221. De-Bleecker J, van-Den-Neucker K, Colradyn F, (1993).Intermediate syndromeinOrganophospharus poising: a prospective
  222. Dimethoateon different regions of thebrain inAlbino rat. (In Press)
  223. Beyer WE.Fridovich I.(1987). Assaying for SOD activity some large consequences of minor changes in conditions. 161 :
  224. Devi Srilakshmi Kala S, Umakanthi V, Jayasudha M, Malleswari M, RavikanthSV and Jacob Doss P,(2013). Effect of
  225. Del Rio D, Stewart AJ, Pellegrini NA, (2005).review of recent studies on malonialdehyde as toxic molecule and biological
  226. Sharma Y, BashirS,Irshad M, DattaguptaS,Dogra, TD, (2005b.). Dimethoate- induced effects on antioxidant status of liver
  227. poising.J Toxicol Clin toxicol 33(3):257-60.
  228. lesions, measurement and substrate specificity of DNA repair glycosylases. Biol Chem 383:93
  229. 559-66
  230. insecticides in urine for human bio monitoring in environmental medicine. Int J Hyg Environ Health, 209: 293-9.
  231. Cadet J, Bellon S, Berger M,Bourdat AG, Douki T,DuarteV, (2002). Recent aspects of oxidative DNA damage: guanine
  232. study. Crit Care Med 21(11): 1706-11.
  233. Toxicologic Pathology 59:237-243.
  234. Goetz ME, Luch A, (2008).Reactive species: a cell damaging rout assisting to chemical carcinogens. Cancer Lett 266: 73-
  235. 16:1.
  236. marker of oxidative stress. Nutr Metab Cardiovasc Dis 15:316-28.
  237. Aebi H, (1984). Catalase in vitro. Methods enzymol 105:121-6.
  238. Beyer WE.Fridovich I.(1987). Assaying for SOD activity some large consequences of minor changes in conditions. 161 :
  239. Devi Srilakshmi Kala S, Umakanthi V, Jayasudha M, Malleswari M, RavikanthSV and Jacob Doss P,(2013). Effect of
  240. FerahSayim, (2007) Dimethoate-induced biochemical and histopathological changes in the liver of rats. Experimental and
  241. Med 119:598-620
  242. 83.
  243. Betrosian A, Balla M,Kafiri G,Kofinas G, Makri R,Kakouri A. (1995). Multiple systems organ failure from organophosphate
  244. Fridovich I, Beachamp,(1995). Superoxide radical and superoxide dismutases. Annu.Rev.Biochem, 64-97.
  245. FerahSayim, (2007) Dimethoate-induced biochemical and histopathological changes in the liver of rats. Experimental and
  246. Med 119:598-620
  247. Halliwell B, Guteride JMC, Cross CE, (1992). Free radicals, antioxidants and human disease: where we now? J Lab Clin
  248. Halliwell B, Guteride JMC, Cross CE, (1992). Free radicals, antioxidants and human disease: where we now? J Lab Clin
  249. De-Bleecker J, van-Den-Neucker K, Colradyn F, (1993).Intermediate syndromeinOrganophospharus poising: a prospective
  250. Beyer WE.Fridovich I.(1987). Assaying for SOD activity some large consequences of minor changes in conditions. 161 :
  251. Devi Srilakshmi Kala S, Umakanthi V, Jayasudha M, Malleswari M, RavikanthSV and Jacob Doss P,(2013). Effect of
  252. 16:1.
  253. marker of oxidative stress. Nutr Metab Cardiovasc Dis 15:316-28.
  254. study. Crit Care Med 21(11): 1706-11.
  255. 16:1.
  256. marker of oxidative stress. Nutr Metab Cardiovasc Dis 15:316-28.
  257. Toxicologic Pathology 59:237-243.
  258. Goetz ME, Luch A, (2008).Reactive species: a cell damaging rout assisting to chemical carcinogens. Cancer Lett 266: 73-
  259. study. Crit Care Med 21(11): 1706-11.
  260. Toxicologic Pathology 59:237-243.
  261. Goetz ME, Luch A, (2008).Reactive species: a cell damaging rout assisting to chemical carcinogens. Cancer Lett 266: 73-
  262. study. Crit Care Med 21(11): 1706-11.
  263. Beyer WE.Fridovich I.(1987). Assaying for SOD activity some large consequences of minor changes in conditions. 161 :
  264. Devi Srilakshmi Kala S, Umakanthi V, Jayasudha M, Malleswari M, RavikanthSV and Jacob Doss P,(2013). Effect of
  265. Beyer WE.Fridovich I.(1987). Assaying for SOD activity some large consequences of minor changes in conditions. 161 :
  266. Devi Srilakshmi Kala S, Umakanthi V, Jayasudha M, Malleswari M, RavikanthSV and Jacob Doss P,(2013). Effect of
  267. Del Rio D, Stewart AJ, Pellegrini NA, (2005).review of recent studies on malonialdehyde as toxic molecule and biological
  268. Sharma Y, BashirS,Irshad M, DattaguptaS,Dogra, TD, (2005b.). Dimethoate- induced effects on antioxidant status of liver
  269. intoxication on rat pancreass. Toxicol Lett 133:161-70.
  270. Aebi H, (1984). Catalase in vitro. Methods enzymol 105:121-6.
  271. 16:1.
  272. marker of oxidative stress. Nutr Metab Cardiovasc Dis 15:316-28.
  273. 16:1.
  274. marker of oxidative stress. Nutr Metab Cardiovasc Dis 15:316-28.
  275. Halliwell B, Guteride JMC, Cross CE, (1992). Free radicals, antioxidants and human disease: where we now? J Lab Clin
  276. intoxication on rat pancreass. Toxicol Lett 133:161-70.
  277. Halliwell B, Guteride JMC, Cross CE, (1992). Free radicals, antioxidants and human disease: where we now? J Lab Clin
  278. Del Rio D, Stewart AJ, Pellegrini NA, (2005).review of recent studies on malonialdehyde as toxic molecule and biological
  279. Sharma Y, BashirS,Irshad M, DattaguptaS,Dogra, TD, (2005b.). Dimethoate- induced effects on antioxidant status of liver
  280. FerahSayim, (2007) Dimethoate-induced biochemical and histopathological changes in the liver of rats. Experimental and
  281. Med 119:598-620
  282. Toxicologic Pathology 59:237-243.
  283. Goetz ME, Luch A, (2008).Reactive species: a cell damaging rout assisting to chemical carcinogens. Cancer Lett 266: 73-
  284. Hagar HH, Fahmy AH, (2002). A biochemical, histochemical and ultrastructural evaluation of the effect of Dimethoate
  285. Cadet J, Bellon S, Berger M,Bourdat AG, Douki T,DuarteV, (2002). Recent aspects of oxidative DNA damage: guanine
  286. De-Bleecker J, van-Den-Neucker K, Colradyn F, (1993).Intermediate syndromeinOrganophospharus poising: a prospective
  287. De-Bleecker J, van-Den-Neucker K, Colradyn F, (1993).Intermediate syndromeinOrganophospharus poising: a prospective
  288. Betrosian A, Balla M,Kafiri G,Kofinas G, Makri R,Kakouri A. (1995). Multiple systems organ failure from organophosphate
  289. Fridovich I, Beachamp,(1995). Superoxide radical and superoxide dismutases. Annu.Rev.Biochem, 64-97.
  290. 559-66
  291. insecticides in urine for human bio monitoring in environmental medicine. Int J Hyg Environ Health, 209: 293-9.
  292. 83.
  293. Betrosian A, Balla M,Kafiri G,Kofinas G, Makri R,Kakouri A. (1995). Multiple systems organ failure from organophosphate
  294. Fridovich I, Beachamp,(1995). Superoxide radical and superoxide dismutases. Annu.Rev.Biochem, 64-97.
  295. Aebi H, (1984). Catalase in vitro. Methods enzymol 105:121-6.
  296. Betrosian A, Balla M,Kafiri G,Kofinas G, Makri R,Kakouri A. (1995). Multiple systems organ failure from organophosphate
  297. Fridovich I, Beachamp,(1995). Superoxide radical and superoxide dismutases. Annu.Rev.Biochem, 64-97.
  298. Dimethoateon different regions of thebrain inAlbino rat. (In Press)
  299. FerahSayim, (2007) Dimethoate-induced biochemical and histopathological changes in the liver of rats. Experimental and
  300. Med 119:598-620
  301. FerahSayim, (2007) Dimethoate-induced biochemical and histopathological changes in the liver of rats. Experimental and
  302. Med 119:598-620
  303. De-Bleecker J, van-Den-Neucker K, Colradyn F, (1993).Intermediate syndromeinOrganophospharus poising: a prospective
  304. FerahSayim, (2007) Dimethoate-induced biochemical and histopathological changes in the liver of rats. Experimental and
  305. Med 119:598-620
  306. Del Rio D, Stewart AJ, Pellegrini NA, (2005).review of recent studies on malonialdehyde as toxic molecule and biological
  307. Sharma Y, BashirS,Irshad M, DattaguptaS,Dogra, TD, (2005b.). Dimethoate- induced effects on antioxidant status of liver
  308. FerahSayim, (2007) Dimethoate-induced biochemical and histopathological changes in the liver of rats. Experimental and
  309. Manna, S, BhattacharyyaD, MandalTKand Das S, (2005). Reported dose toxicity of Deltamethrin in rats. Indian journal of
  310. pharmacology, 37(3): 160-164.
  311. and brain of rats following subchronic exposure, Toxicology, 215: 2005b, p. 173-181.
  312. 16:1.
  313. marker of oxidative stress. Nutr Metab Cardiovasc Dis 15:316-28.
  314. Med 119:598-620
  315. Toxicologic Pathology 59:237-243.
  316. Goetz ME, Luch A, (2008).Reactive species: a cell damaging rout assisting to chemical carcinogens. Cancer Lett 266: 73-
  317. Betrosian A, Balla M,Kafiri G,Kofinas G, Makri R,Kakouri A. (1995). Multiple systems organ failure from organophosphate
  318. Fridovich I, Beachamp,(1995). Superoxide radical and superoxide dismutases. Annu.Rev.Biochem, 64-97.
  319. FerahSayim, (2007) Dimethoate-induced biochemical and histopathological changes in the liver of rats. Experimental and
  320. Med 119:598-620
  321. Halliwell B, Guteride JMC, Cross CE, (1992). Free radicals, antioxidants and human disease: where we now? J Lab Clin
  322. Manna, S, BhattacharyyaD, MandalTKand Das S, (2005). Reported dose toxicity of Deltamethrin in rats. Indian journal of
  323. pharmacology, 37(3): 160-164.
  324. and brain of rats following subchronic exposure, Toxicology, 215: 2005b, p. 173-181.
  325. Toxicologic Pathology 59:237-243.
  326. Toxicologic Pathology 59:237-243.
  327. Goetz ME, Luch A, (2008).Reactive species: a cell damaging rout assisting to chemical carcinogens. Cancer Lett 266: 73-
  328. Beyer WE.Fridovich I.(1987). Assaying for SOD activity some large consequences of minor changes in conditions. 161 :
  329. Devi Srilakshmi Kala S, Umakanthi V, Jayasudha M, Malleswari M, RavikanthSV and Jacob Doss P,(2013). Effect of
  330. Betrosian A, Balla M,Kafiri G,Kofinas G, Makri R,Kakouri A. (1995). Multiple systems organ failure from organophosphate
  331. Fridovich I, Beachamp,(1995). Superoxide radical and superoxide dismutases. Annu.Rev.Biochem, 64-97.
  332. Dimethoateon different regions of thebrain inAlbino rat. (In Press)
  333. Cadet J, Bellon S, Berger M,Bourdat AG, Douki T,DuarteV, (2002). Recent aspects of oxidative DNA damage: guanine
  334. Halliwell B, Guteride JMC, Cross CE, (1992). Free radicals, antioxidants and human disease: where we now? J Lab Clin
  335. study. Crit Care Med 21(11): 1706-11.
  336. Aebi H, (1984). Catalase in vitro. Methods enzymol 105:121-6.
  337. FerahSayim, (2007) Dimethoate-induced biochemical and histopathological changes in the liver of rats. Experimental and
  338. Med 119:598-620
  339. 559-66
  340. insecticides in urine for human bio monitoring in environmental medicine. Int J Hyg Environ Health, 209: 293-9.
  341. Hagar HH, Fahmy AH, (2002). A biochemical, histochemical and ultrastructural evaluation of the effect of Dimethoate
  342. 16:1.
  343. marker of oxidative stress. Nutr Metab Cardiovasc Dis 15:316-28.
  344. Hagar HH, Fahmy AH, (2002). A biochemical, histochemical and ultrastructural evaluation of the effect of Dimethoate
  345. Goetz ME, Luch A, (2008).Reactive species: a cell damaging rout assisting to chemical carcinogens. Cancer Lett 266: 73-
  346. Betrosian A, Balla M,Kafiri G,Kofinas G, Makri R,Kakouri A. (1995). Multiple systems organ failure from organophosphate
  347. Fridovich I, Beachamp,(1995). Superoxide radical and superoxide dismutases. Annu.Rev.Biochem, 64-97.
  348. Beyer WE.Fridovich I.(1987). Assaying for SOD activity some large consequences of minor changes in conditions. 161 :
  349. Devi Srilakshmi Kala S, Umakanthi V, Jayasudha M, Malleswari M, RavikanthSV and Jacob Doss P,(2013). Effect of
  350. 16:1.
  351. marker of oxidative stress. Nutr Metab Cardiovasc Dis 15:316-28.
  352. Beyer WE.Fridovich I.(1987). Assaying for SOD activity some large consequences of minor changes in conditions. 161 :
  353. Devi Srilakshmi Kala S, Umakanthi V, Jayasudha M, Malleswari M, RavikanthSV and Jacob Doss P,(2013). Effect of
  354. Halliwell B, Guteride JMC, Cross CE, (1992). Free radicals, antioxidants and human disease: where we now? J Lab Clin
  355. Hagar HH, Fahmy AH, (2002). A biochemical, histochemical and ultrastructural evaluation of the effect of Dimethoate
  356. Dimethoateon different regions of thebrain inAlbino rat. (In Press)
  357. 16:1.
  358. marker of oxidative stress. Nutr Metab Cardiovasc Dis 15:316-28.
  359. Toxicologic Pathology 59:237-243.
  360. Goetz ME, Luch A, (2008).Reactive species: a cell damaging rout assisting to chemical carcinogens. Cancer Lett 266: 73-
  361. FerahSayim, (2007) Dimethoate-induced biochemical and histopathological changes in the liver of rats. Experimental and
  362. Med 119:598-620
  363. intoxication on rat pancreass. Toxicol Lett 133:161-70.
  364. Del Rio D, Stewart AJ, Pellegrini NA, (2005).review of recent studies on malonialdehyde as toxic molecule and biological
  365. Sharma Y, BashirS,Irshad M, DattaguptaS,Dogra, TD, (2005b.). Dimethoate- induced effects on antioxidant status of liver
  366. Del Rio D, Stewart AJ, Pellegrini NA, (2005).review of recent studies on malonialdehyde as toxic molecule and biological
  367. Sharma Y, BashirS,Irshad M, DattaguptaS,Dogra, TD, (2005b.). Dimethoate- induced effects on antioxidant status of liver
  368. poising.J Toxicol Clin toxicol 33(3):257-60.
  369. lesions, measurement and substrate specificity of DNA repair glycosylases. Biol Chem 383:93
  370. Beyer WE.Fridovich I.(1987). Assaying for SOD activity some large consequences of minor changes in conditions. 161 :
  371. Devi Srilakshmi Kala S, Umakanthi V, Jayasudha M, Malleswari M, RavikanthSV and Jacob Doss P,(2013). Effect of
  372. Del Rio D, Stewart AJ, Pellegrini NA, (2005).review of recent studies on malonialdehyde as toxic molecule and biological
  373. Sharma Y, BashirS,Irshad M, DattaguptaS,Dogra, TD, (2005b.). Dimethoate- induced effects on antioxidant status of liver
  374. 16:1.
  375. marker of oxidative stress. Nutr Metab Cardiovasc Dis 15:316-28.
  376. Banerjee BD, Seth V.Ahmad RS.(2001). Pesticide – induced oxidative stress: perspective and trands. Rev environ health
  377. Heudorf U, ButteW, Schulz C, Angerer J, (2006). Reference values for metabolites of pyrethroid and organophosphorus
  378. Del Rio D, Stewart AJ, Pellegrini NA, (2005).review of recent studies on malonialdehyde as toxic molecule and biological
  379. Sharma Y, BashirS,Irshad M, DattaguptaS,Dogra, TD, (2005b.). Dimethoate- induced effects on antioxidant status of liver
  380. Banerjee BD, Seth V.Ahmad RS.(2001). Pesticide – induced oxidative stress: perspective and trands. Rev environ health
  381. Heudorf U, ButteW, Schulz C, Angerer J, (2006). Reference values for metabolites of pyrethroid and organophosphorus
  382. intoxication on rat pancreass. Toxicol Lett 133:161-70.
  383. Manna, S, BhattacharyyaD, MandalTKand Das S, (2005). Reported dose toxicity of Deltamethrin in rats. Indian journal of
  384. pharmacology, 37(3): 160-164.
  385. and brain of rats following subchronic exposure, Toxicology, 215: 2005b, p. 173-181.
  386. 83.
  387. 559-66
  388. insecticides in urine for human bio monitoring in environmental medicine. Int J Hyg Environ Health, 209: 293-9.
  389. lesions, measurement and substrate specificity of DNA repair glycosylases. Biol Chem 383:93
  390. 83.
  391. 559-66
  392. insecticides in urine for human bio monitoring in environmental medicine. Int J Hyg Environ Health, 209: 293-9.
  393. Cadet J, Bellon S, Berger M,Bourdat AG, Douki T,DuarteV, (2002). Recent aspects of oxidative DNA damage: guanine
  394. Aebi H, (1984). Catalase in vitro. Methods enzymol 105:121-6.
  395. Cadet J, Bellon S, Berger M,Bourdat AG, Douki T,DuarteV, (2002). Recent aspects of oxidative DNA damage: guanine
  396. De-Bleecker J, van-Den-Neucker K, Colradyn F, (1993).Intermediate syndromeinOrganophospharus poising: a prospective
  397. Beyer WE.Fridovich I.(1987). Assaying for SOD activity some large consequences of minor changes in conditions. 161 :
  398. Devi Srilakshmi Kala S, Umakanthi V, Jayasudha M, Malleswari M, RavikanthSV and Jacob Doss P,(2013). Effect of
  399. Beyer WE.Fridovich I.(1987). Assaying for SOD activity some large consequences of minor changes in conditions. 161 :
  400. Devi Srilakshmi Kala S, Umakanthi V, Jayasudha M, Malleswari M, RavikanthSV and Jacob Doss P,(2013). Effect of
  401. Cadet J, Bellon S, Berger M,Bourdat AG, Douki T,DuarteV, (2002). Recent aspects of oxidative DNA damage: guanine
  402. 16:1.
  403. marker of oxidative stress. Nutr Metab Cardiovasc Dis 15:316-28.
  404. Hagar HH, Fahmy AH, (2002). A biochemical, histochemical and ultrastructural evaluation of the effect of Dimethoate
  405. Beyer WE.Fridovich I.(1987). Assaying for SOD activity some large consequences of minor changes in conditions. 161 :
  406. Devi Srilakshmi Kala S, Umakanthi V, Jayasudha M, Malleswari M, RavikanthSV and Jacob Doss P,(2013). Effect of
  407. Halliwell B, Guteride JMC, Cross CE, (1992). Free radicals, antioxidants and human disease: where we now? J Lab Clin
  408. Hagar HH, Fahmy AH, (2002). A biochemical, histochemical and ultrastructural evaluation of the effect of Dimethoate
  409. De-Bleecker J, van-Den-Neucker K, Colradyn F, (1993).Intermediate syndromeinOrganophospharus poising: a prospective
  410. poising.J Toxicol Clin toxicol 33(3):257-60.
  411. lesions, measurement and substrate specificity of DNA repair glycosylases. Biol Chem 383:93
  412. poising.J Toxicol Clin toxicol 33(3):257-60.
  413. Banerjee BD, Seth V.Ahmad RS.(2001). Pesticide – induced oxidative stress: perspective and trands. Rev environ health
  414. Heudorf U, ButteW, Schulz C, Angerer J, (2006). Reference values for metabolites of pyrethroid and organophosphorus
  415. Manna, S, BhattacharyyaD, MandalTKand Das S, (2005). Reported dose toxicity of Deltamethrin in rats. Indian journal of
  416. pharmacology, 37(3): 160-164.
  417. and brain of rats following subchronic exposure, Toxicology, 215: 2005b, p. 173-181.
  418. Beyer WE.Fridovich I.(1987). Assaying for SOD activity some large consequences of minor changes in conditions. 161 :
  419. Devi Srilakshmi Kala S, Umakanthi V, Jayasudha M, Malleswari M, RavikanthSV and Jacob Doss P,(2013). Effect of
  420. Toxicologic Pathology 59:237-243.
  421. Goetz ME, Luch A, (2008).Reactive species: a cell damaging rout assisting to chemical carcinogens. Cancer Lett 266: 73-
  422. 83.
  423. Aebi H, (1984). Catalase in vitro. Methods enzymol 105:121-6.
  424. 559-66
  425. insecticides in urine for human bio monitoring in environmental medicine. Int J Hyg Environ Health, 209: 293-9.
  426. Beyer WE.Fridovich I.(1987). Assaying for SOD activity some large consequences of minor changes in conditions. 161 :
  427. Devi Srilakshmi Kala S, Umakanthi V, Jayasudha M, Malleswari M, RavikanthSV and Jacob Doss P,(2013). Effect of
  428. 83.
  429. Del Rio D, Stewart AJ, Pellegrini NA, (2005).review of recent studies on malonialdehyde as toxic molecule and biological
  430. Aebi H, (1984). Catalase in vitro. Methods enzymol 105:121-6.
  431. Banerjee BD, Seth V.Ahmad RS.(2001). Pesticide – induced oxidative stress: perspective and trands. Rev environ health
  432. Heudorf U, ButteW, Schulz C, Angerer J, (2006). Reference values for metabolites of pyrethroid and organophosphorus
  433. Sharma Y, BashirS,Irshad M, DattaguptaS,Dogra, TD, (2005b.). Dimethoate- induced effects on antioxidant status of liver
  434. Toxicologic Pathology 59:237-243.
  435. Goetz ME, Luch A, (2008).Reactive species: a cell damaging rout assisting to chemical carcinogens. Cancer Lett 266: 73-
  436. Halliwell B, Guteride JMC, Cross CE, (1992). Free radicals, antioxidants and human disease: where we now? J Lab Clin
  437. De-Bleecker J, van-Den-Neucker K, Colradyn F, (1993).Intermediate syndromeinOrganophospharus poising: a prospective
  438. Banerjee BD, Seth V.Ahmad RS.(2001). Pesticide – induced oxidative stress: perspective and trands. Rev environ health
  439. Heudorf U, ButteW, Schulz C, Angerer J, (2006). Reference values for metabolites of pyrethroid and organophosphorus
  440. Del Rio D, Stewart AJ, Pellegrini NA, (2005).review of recent studies on malonialdehyde as toxic molecule and biological
  441. Sharma Y, BashirS,Irshad M, DattaguptaS,Dogra, TD, (2005b.). Dimethoate- induced effects on antioxidant status of liver
  442. study. Crit Care Med 21(11): 1706-11.
  443. De-Bleecker J, van-Den-Neucker K, Colradyn F, (1993).Intermediate syndromeinOrganophospharus poising: a prospective
  444. Cadet J, Bellon S, Berger M,Bourdat AG, Douki T,DuarteV, (2002). Recent aspects of oxidative DNA damage: guanine
  445. Dimethoateon different regions of thebrain inAlbino rat. (In Press)
  446. intoxication on rat pancreass. Toxicol Lett 133:161-70.
  447. Beyer WE.Fridovich I.(1987). Assaying for SOD activity some large consequences of minor changes in conditions. 161 :
  448. Devi Srilakshmi Kala S, Umakanthi V, Jayasudha M, Malleswari M, RavikanthSV and Jacob Doss P,(2013). Effect of
  449. Beyer WE.Fridovich I.(1987). Assaying for SOD activity some large consequences of minor changes in conditions. 161 :
  450. Devi Srilakshmi Kala S, Umakanthi V, Jayasudha M, Malleswari M, RavikanthSV and Jacob Doss P,(2013). Effect of
  451. Devi Srilakshmi Kala S, Umakanthi V, Jayasudha M, Malleswari M, RavikanthSV and Jacob Doss P,(2013). Effect of
  452. Manna, S, BhattacharyyaD, MandalTKand Das S, (2005). Reported dose toxicity of Deltamethrin in rats. Indian journal of
  453. pharmacology, 37(3): 160-164.
  454. and brain of rats following subchronic exposure, Toxicology, 215: 2005b, p. 173-181.
  455. Manna, S, BhattacharyyaD, MandalTKand Das S, (2005). Reported dose toxicity of Deltamethrin in rats. Indian journal of
  456. pharmacology, 37(3): 160-164.
  457. and brain of rats following subchronic exposure, Toxicology, 215: 2005b, p. 173-181.
  458. intoxication on rat pancreass. Toxicol Lett 133:161-70.
  459. poising.J Toxicol Clin toxicol 33(3):257-60.
  460. lesions, measurement and substrate specificity of DNA repair glycosylases. Biol Chem 383:93
  461. Banerjee BD, Seth V.Ahmad RS.(2001). Pesticide – induced oxidative stress: perspective and trands. Rev environ health
  462. Heudorf U, ButteW, Schulz C, Angerer J, (2006). Reference values for metabolites of pyrethroid and organophosphorus
  463. 16:1.
  464. marker of oxidative stress. Nutr Metab Cardiovasc Dis 15:316-28.
  465. Toxicologic Pathology 59:237-243.
  466. Goetz ME, Luch A, (2008).Reactive species: a cell damaging rout assisting to chemical carcinogens. Cancer Lett 266: 73-
  467. Manna, S, BhattacharyyaD, MandalTKand Das S, (2005). Reported dose toxicity of Deltamethrin in rats. Indian journal of
  468. pharmacology, 37(3): 160-164.
  469. and brain of rats following subchronic exposure, Toxicology, 215: 2005b, p. 173-181.
  470. Beyer WE.Fridovich I.(1987). Assaying for SOD activity some large consequences of minor changes in conditions. 161 :
  471. 83.
  472. intoxication on rat pancreass. Toxicol Lett 133:161-70.
  473. Betrosian A, Balla M,Kafiri G,Kofinas G, Makri R,Kakouri A. (1995). Multiple systems organ failure from organophosphate
  474. Fridovich I, Beachamp,(1995). Superoxide radical and superoxide dismutases. Annu.Rev.Biochem, 64-97.
  475. 559-66
  476. insecticides in urine for human bio monitoring in environmental medicine. Int J Hyg Environ Health, 209: 293-9.
  477. Beyer WE.Fridovich I.(1987). Assaying for SOD activity some large consequences of minor changes in conditions. 161 :
  478. Devi Srilakshmi Kala S, Umakanthi V, Jayasudha M, Malleswari M, RavikanthSV and Jacob Doss P,(2013). Effect of
  479. Toxicologic Pathology 59:237-243.
  480. Goetz ME, Luch A, (2008).Reactive species: a cell damaging rout assisting to chemical carcinogens. Cancer Lett 266: 73-
  481. study. Crit Care Med 21(11): 1706-11.
  482. Beyer WE.Fridovich I.(1987). Assaying for SOD activity some large consequences of minor changes in conditions. 161 :
  483. Devi Srilakshmi Kala S, Umakanthi V, Jayasudha M, Malleswari M, RavikanthSV and Jacob Doss P,(2013). Effect of
  484. Banerjee BD, Seth V.Ahmad RS.(2001). Pesticide – induced oxidative stress: perspective and trands. Rev environ health
  485. Heudorf U, ButteW, Schulz C, Angerer J, (2006). Reference values for metabolites of pyrethroid and organophosphorus
  486. intoxication on rat pancreass. Toxicol Lett 133:161-70.
  487. Banerjee BD, Seth V.Ahmad RS.(2001). Pesticide – induced oxidative stress: perspective and trands. Rev environ health
  488. Heudorf U, ButteW, Schulz C, Angerer J, (2006). Reference values for metabolites of pyrethroid and organophosphorus
  489. Betrosian A, Balla M,Kafiri G,Kofinas G, Makri R,Kakouri A. (1995). Multiple systems organ failure from organophosphate
  490. Beyer WE.Fridovich I.(1987). Assaying for SOD activity some large consequences of minor changes in conditions. 161 :
  491. Devi Srilakshmi Kala S, Umakanthi V, Jayasudha M, Malleswari M, RavikanthSV and Jacob Doss P,(2013). Effect of
  492. 16:1.
  493. marker of oxidative stress. Nutr Metab Cardiovasc Dis 15:316-28.
  494. Betrosian A, Balla M,Kafiri G,Kofinas G, Makri R,Kakouri A. (1995). Multiple systems organ failure from organophosphate
  495. Fridovich I, Beachamp,(1995). Superoxide radical and superoxide dismutases. Annu.Rev.Biochem, 64-97.
  496. Toxicologic Pathology 59:237-243.
  497. Goetz ME, Luch A, (2008).Reactive species: a cell damaging rout assisting to chemical carcinogens. Cancer Lett 266: 73-
  498. Fridovich I, Beachamp,(1995). Superoxide radical and superoxide dismutases. Annu.Rev.Biochem, 64-97.
  499. Beyer WE.Fridovich I.(1987). Assaying for SOD activity some large consequences of minor changes in conditions. 161 :
  500. Devi Srilakshmi Kala S, Umakanthi V, Jayasudha M, Malleswari M, RavikanthSV and Jacob Doss P,(2013). Effect of
  501. Toxicologic Pathology 59:237-243.
  502. Goetz ME, Luch A, (2008).Reactive species: a cell damaging rout assisting to chemical carcinogens. Cancer Lett 266: 73-
  503. Dimethoateon different regions of thebrain inAlbino rat. (In Press)
  504. study. Crit Care Med 21(11): 1706-11.
  505. Banerjee BD, Seth V.Ahmad RS.(2001). Pesticide – induced oxidative stress: perspective and trands. Rev environ health
  506. Heudorf U, ButteW, Schulz C, Angerer J, (2006). Reference values for metabolites of pyrethroid and organophosphorus
  507. Del Rio D, Stewart AJ, Pellegrini NA, (2005).review of recent studies on malonialdehyde as toxic molecule and biological
  508. Sharma Y, BashirS,Irshad M, DattaguptaS,Dogra, TD, (2005b.). Dimethoate- induced effects on antioxidant status of liver
  509. 83.
  510. 559-66
  511. insecticides in urine for human bio monitoring in environmental medicine. Int J Hyg Environ Health, 209: 293-9.
  512. Del Rio D, Stewart AJ, Pellegrini NA, (2005).review of recent studies on malonialdehyde as toxic molecule and biological
  513. and brain of rats following subchronic exposure, Toxicology, 215: 2005b, p. 173-181.
  514. Sharma Y, BashirS,Irshad M, DattaguptaS,Dogra, TD, (2005b.). Dimethoate- induced effects on antioxidant status of liver
  515. 83.
  516. Beyer WE.Fridovich I.(1987). Assaying for SOD activity some large consequences of minor changes in conditions. 161 :
  517. Devi Srilakshmi Kala S, Umakanthi V, Jayasudha M, Malleswari M, RavikanthSV and Jacob Doss P,(2013). Effect of
  518. Cadet J, Bellon S, Berger M,Bourdat AG, Douki T,DuarteV, (2002). Recent aspects of oxidative DNA damage: guanine
  519. Toxicologic Pathology 59:237-243.
  520. Goetz ME, Luch A, (2008).Reactive species: a cell damaging rout assisting to chemical carcinogens. Cancer Lett 266: 73-
  521. Dimethoateon different regions of thebrain inAlbino rat. (In Press)
  522. 559-66
  523. insecticides in urine for human bio monitoring in environmental medicine. Int J Hyg Environ Health, 209: 293-9.
  524. 559-66
  525. insecticides in urine for human bio monitoring in environmental medicine. Int J Hyg Environ Health, 209: 293-9.
  526. Hagar HH, Fahmy AH, (2002). A biochemical, histochemical and ultrastructural evaluation of the effect of Dimethoate
  527. De-Bleecker J, van-Den-Neucker K, Colradyn F, (1993).Intermediate syndromeinOrganophospharus poising: a prospective
  528. De-Bleecker J, van-Den-Neucker K, Colradyn F, (1993).Intermediate syndromeinOrganophospharus poising: a prospective
  529. Manna, S, BhattacharyyaD, MandalTKand Das S, (2005). Reported dose toxicity of Deltamethrin in rats. Indian journal of
  530. pharmacology, 37(3): 160-164.
  531. 559-66
  532. Beyer WE.Fridovich I.(1987). Assaying for SOD activity some large consequences of minor changes in conditions. 161 :
  533. Devi Srilakshmi Kala S, Umakanthi V, Jayasudha M, Malleswari M, RavikanthSV and Jacob Doss P,(2013). Effect of
  534. poising.J Toxicol Clin toxicol 33(3):257-60.
  535. lesions, measurement and substrate specificity of DNA repair glycosylases. Biol Chem 383:93
  536. insecticides in urine for human bio monitoring in environmental medicine. Int J Hyg Environ Health, 209: 293-9.
  537. Betrosian A, Balla M,Kafiri G,Kofinas G, Makri R,Kakouri A. (1995). Multiple systems organ failure from organophosphate
  538. Fridovich I, Beachamp,(1995). Superoxide radical and superoxide dismutases. Annu.Rev.Biochem, 64-97.
  539. Dimethoateon different regions of thebrain inAlbino rat. (In Press)
  540. study. Crit Care Med 21(11): 1706-11.
  541. Betrosian A, Balla M,Kafiri G,Kofinas G, Makri R,Kakouri A. (1995). Multiple systems organ failure from organophosphate
  542. Fridovich I, Beachamp,(1995). Superoxide radical and superoxide dismutases. Annu.Rev.Biochem, 64-97.
  543. intoxication on rat pancreass. Toxicol Lett 133:161-70.
  544. De-Bleecker J, van-Den-Neucker K, Colradyn F, (1993).Intermediate syndromeinOrganophospharus poising: a prospective
  545. Beyer WE.Fridovich I.(1987). Assaying for SOD activity some large consequences of minor changes in conditions. 161 :
  546. Devi Srilakshmi Kala S, Umakanthi V, Jayasudha M, Malleswari M, RavikanthSV and Jacob Doss P,(2013). Effect of
  547. 83.
  548. Halliwell B, Guteride JMC, Cross CE, (1992). Free radicals, antioxidants and human disease: where we now? J Lab Clin
  549. 16:1.
  550. marker of oxidative stress. Nutr Metab Cardiovasc Dis 15:316-28.
  551. Beyer WE.Fridovich I.(1987). Assaying for SOD activity some large consequences of minor changes in conditions. 161 :
  552. Devi Srilakshmi Kala S, Umakanthi V, Jayasudha M, Malleswari M, RavikanthSV and Jacob Doss P,(2013). Effect of
  553. Cadet J, Bellon S, Berger M,Bourdat AG, Douki T,DuarteV, (2002). Recent aspects of oxidative DNA damage: guanine
  554. Del Rio D, Stewart AJ, Pellegrini NA, (2005).review of recent studies on malonialdehyde as toxic molecule and biological
  555. Sharma Y, BashirS,Irshad M, DattaguptaS,Dogra, TD, (2005b.). Dimethoate- induced effects on antioxidant status of liver
  556. 83.
  557. De-Bleecker J, van-Den-Neucker K, Colradyn F, (1993).Intermediate syndromeinOrganophospharus poising: a prospective
  558. Del Rio D, Stewart AJ, Pellegrini NA, (2005).review of recent studies on malonialdehyde as toxic molecule and biological
  559. Sharma Y, BashirS,Irshad M, DattaguptaS,Dogra, TD, (2005b.). Dimethoate- induced effects on antioxidant status of liver
  560. Beyer WE.Fridovich I.(1987). Assaying for SOD activity some large consequences of minor changes in conditions. 161 :
  561. 83.
  562. Del Rio D, Stewart AJ, Pellegrini NA, (2005).review of recent studies on malonialdehyde as toxic molecule and biological
  563. Toxicologic Pathology 59:237-243.
  564. Toxicologic Pathology 59:237-243.
  565. Goetz ME, Luch A, (2008).Reactive species: a cell damaging rout assisting to chemical carcinogens. Cancer Lett 266: 73-
  566. FerahSayim, (2007) Dimethoate-induced biochemical and histopathological changes in the liver of rats. Experimental and
  567. Med 119:598-620
  568. Betrosian A, Balla M,Kafiri G,Kofinas G, Makri R,Kakouri A. (1995). Multiple systems organ failure from organophosphate
  569. Fridovich I, Beachamp,(1995). Superoxide radical and superoxide dismutases. Annu.Rev.Biochem, 64-97.
  570. Manna, S, BhattacharyyaD, MandalTKand Das S, (2005). Reported dose toxicity of Deltamethrin in rats. Indian journal of
  571. pharmacology, 37(3): 160-164.
  572. and brain of rats following subchronic exposure, Toxicology, 215: 2005b, p. 173-181.
  573. De-Bleecker J, van-Den-Neucker K, Colradyn F, (1993).Intermediate syndromeinOrganophospharus poising: a prospective
  574. Betrosian A, Balla M,Kafiri G,Kofinas G, Makri R,Kakouri A. (1995). Multiple systems organ failure from organophosphate
  575. Fridovich I, Beachamp,(1995). Superoxide radical and superoxide dismutases. Annu.Rev.Biochem, 64-97.
  576. FerahSayim, (2007) Dimethoate-induced biochemical and histopathological changes in the liver of rats. Experimental and
  577. Med 119:598-620
  578. Betrosian A, Balla M,Kafiri G,Kofinas G, Makri R,Kakouri A. (1995). Multiple systems organ failure from organophosphate
  579. Fridovich I, Beachamp,(1995). Superoxide radical and superoxide dismutases. Annu.Rev.Biochem, 64-97.
  580. FerahSayim, (2007) Dimethoate-induced biochemical and histopathological changes in the liver of rats. Experimental and
  581. Med 119:598-620
  582. Toxicologic Pathology 59:237-243.
  583. Goetz ME, Luch A, (2008).Reactive species: a cell damaging rout assisting to chemical carcinogens. Cancer Lett 266: 73-
  584. 83.
  585. Aebi H, (1984). Catalase in vitro. Methods enzymol 105:121-6.
  586. 83.
  587. Aebi H, (1984). Catalase in vitro. Methods enzymol 105:121-6.
  588. Goetz ME, Luch A, (2008).Reactive species: a cell damaging rout assisting to chemical carcinogens. Cancer Lett 266: 73-
  589. Banerjee BD, Seth V.Ahmad RS.(2001). Pesticide – induced oxidative stress: perspective and trands. Rev environ health
  590. Heudorf U, ButteW, Schulz C, Angerer J, (2006). Reference values for metabolites of pyrethroid and organophosphorus
  591. 559-66
  592. insecticides in urine for human bio monitoring in environmental medicine. Int J Hyg Environ Health, 209: 293-9.
  593. Manna, S, BhattacharyyaD, MandalTKand Das S, (2005). Reported dose toxicity of Deltamethrin in rats. Indian journal of
  594. pharmacology, 37(3): 160-164.
  595. and brain of rats following subchronic exposure, Toxicology, 215: 2005b, p. 173-181.
  596. Beyer WE.Fridovich I.(1987). Assaying for SOD activity some large consequences of minor changes in conditions. 161 :
  597. Devi Srilakshmi Kala S, Umakanthi V, Jayasudha M, Malleswari M, RavikanthSV and Jacob Doss P,(2013). Effect of
  598. 559-66
  599. Sharma Y, BashirS,Irshad M, DattaguptaS,Dogra, TD, (2005b.). Dimethoate- induced effects on antioxidant status of liver
  600. Aebi H, (1984). Catalase in vitro. Methods enzymol 105:121-6.
  601. insecticides in urine for human bio monitoring in environmental medicine. Int J Hyg Environ Health, 209: 293-9.
  602. Banerjee BD, Seth V.Ahmad RS.(2001). Pesticide – induced oxidative stress: perspective and trands. Rev environ health
  603. Heudorf U, ButteW, Schulz C, Angerer J, (2006). Reference values for metabolites of pyrethroid and organophosphorus
  604. Del Rio D, Stewart AJ, Pellegrini NA, (2005).review of recent studies on malonialdehyde as toxic molecule and biological
  605. Sharma Y, BashirS,Irshad M, DattaguptaS,Dogra, TD, (2005b.). Dimethoate- induced effects on antioxidant status of liver
  606. Aebi H, (1984). Catalase in vitro. Methods enzymol 105:121-6.
  607. Manna, S, BhattacharyyaD, MandalTKand Das S, (2005). Reported dose toxicity of Deltamethrin in rats. Indian journal of
  608. pharmacology, 37(3): 160-164.
  609. and brain of rats following subchronic exposure, Toxicology, 215: 2005b, p. 173-181.
  610. poising.J Toxicol Clin toxicol 33(3):257-60.
  611. lesions, measurement and substrate specificity of DNA repair glycosylases. Biol Chem 383:93
  612. Devi Srilakshmi Kala S, Umakanthi V, Jayasudha M, Malleswari M, RavikanthSV and Jacob Doss P,(2013). Effect of
  613. Del Rio D, Stewart AJ, Pellegrini NA, (2005).review of recent studies on malonialdehyde as toxic molecule and biological
  614. Sharma Y, BashirS,Irshad M, DattaguptaS,Dogra, TD, (2005b.). Dimethoate- induced effects on antioxidant status of liver
  615. Betrosian A, Balla M,Kafiri G,Kofinas G, Makri R,Kakouri A. (1995). Multiple systems organ failure from organophosphate
  616. Fridovich I, Beachamp,(1995). Superoxide radical and superoxide dismutases. Annu.Rev.Biochem, 64-97.
  617. Beyer WE.Fridovich I.(1987). Assaying for SOD activity some large consequences of minor changes in conditions. 161 :
  618. Del Rio D, Stewart AJ, Pellegrini NA, (2005).review of recent studies on malonialdehyde as toxic molecule and biological
  619. poising.J Toxicol Clin toxicol 33(3):257-60.
  620. lesions, measurement and substrate specificity of DNA repair glycosylases. Biol Chem 383:93
  621. FerahSayim, (2007) Dimethoate-induced biochemical and histopathological changes in the liver of rats. Experimental and
  622. Med 119:598-620
  623. poising.J Toxicol Clin toxicol 33(3):257-60.
  624. lesions, measurement and substrate specificity of DNA repair glycosylases. Biol Chem 383:93
  625. Dimethoateon different regions of thebrain inAlbino rat. (In Press)
  626. FerahSayim, (2007) Dimethoate-induced biochemical and histopathological changes in the liver of rats. Experimental and
  627. Med 119:598-620
  628. Betrosian A, Balla M,Kafiri G,Kofinas G, Makri R,Kakouri A. (1995). Multiple systems organ failure from organophosphate
  629. Fridovich I, Beachamp,(1995). Superoxide radical and superoxide dismutases. Annu.Rev.Biochem, 64-97.
  630. 83.
  631. Halliwell B, Guteride JMC, Cross CE, (1992). Free radicals, antioxidants and human disease: where we now? J Lab Clin
  632. Beyer WE.Fridovich I.(1987). Assaying for SOD activity some large consequences of minor changes in conditions. 161 :
  633. Hagar HH, Fahmy AH, (2002). A biochemical, histochemical and ultrastructural evaluation of the effect of Dimethoate
  634. FerahSayim, (2007) Dimethoate-induced biochemical and histopathological changes in the liver of rats. Experimental and
  635. Med 119:598-620
  636. intoxication on rat pancreass. Toxicol Lett 133:161-70.
  637. Halliwell B, Guteride JMC, Cross CE, (1992). Free radicals, antioxidants and human disease: where we now? J Lab Clin
  638. Hagar HH, Fahmy AH, (2002). A biochemical, histochemical and ultrastructural evaluation of the effect of Dimethoate
  639. Devi Srilakshmi Kala S, Umakanthi V, Jayasudha M, Malleswari M, RavikanthSV and Jacob Doss P,(2013). Effect of
  640. FerahSayim, (2007) Dimethoate-induced biochemical and histopathological changes in the liver of rats. Experimental and
  641. Med 119:598-620
  642. De-Bleecker J, van-Den-Neucker K, Colradyn F, (1993).Intermediate syndromeinOrganophospharus poising: a prospective
  643. Cadet J, Bellon S, Berger M,Bourdat AG, Douki T,DuarteV, (2002). Recent aspects of oxidative DNA damage: guanine
  644. Manna, S, BhattacharyyaD, MandalTKand Das S, (2005). Reported dose toxicity of Deltamethrin in rats. Indian journal of
  645. pharmacology, 37(3): 160-164.
  646. and brain of rats following subchronic exposure, Toxicology, 215: 2005b, p. 173-181.
  647. De-Bleecker J, van-Den-Neucker K, Colradyn F, (1993).Intermediate syndromeinOrganophospharus poising: a prospective
  648. poising.J Toxicol Clin toxicol 33(3):257-60.
  649. Banerjee BD, Seth V.Ahmad RS.(2001). Pesticide – induced oxidative stress: perspective and trands. Rev environ health
  650. Aebi H, (1984). Catalase in vitro. Methods enzymol 105:121-6.
  651. Heudorf U, ButteW, Schulz C, Angerer J, (2006). Reference values for metabolites of pyrethroid and organophosphorus
  652. Toxicologic Pathology 59:237-243.
  653. Goetz ME, Luch A, (2008).Reactive species: a cell damaging rout assisting to chemical carcinogens. Cancer Lett 266: 73-
  654. 16:1.
  655. marker of oxidative stress. Nutr Metab Cardiovasc Dis 15:316-28.
  656. insecticides in urine for human bio monitoring in environmental medicine. Int J Hyg Environ Health, 209: 293-9.
  657. Beyer WE.Fridovich I.(1987). Assaying for SOD activity some large consequences of minor changes in conditions. 161 :
  658. Devi Srilakshmi Kala S, Umakanthi V, Jayasudha M, Malleswari M, RavikanthSV and Jacob Doss P,(2013). Effect of
  659. lesions, measurement and substrate specificity of DNA repair glycosylases. Biol Chem 383:93
  660. intoxication on rat pancreass. Toxicol Lett 133:161-70.
  661. 16:1.
  662. marker of oxidative stress. Nutr Metab Cardiovasc Dis 15:316-28.
  663. Hagar HH, Fahmy AH, (2002). A biochemical, histochemical and ultrastructural evaluation of the effect of Dimethoate
  664. De-Bleecker J, van-Den-Neucker K, Colradyn F, (1993).Intermediate syndromeinOrganophospharus poising: a prospective
  665. Beyer WE.Fridovich I.(1987). Assaying for SOD activity some large consequences of minor changes in conditions. 161 :
  666. Devi Srilakshmi Kala S, Umakanthi V, Jayasudha M, Malleswari M, RavikanthSV and Jacob Doss P,(2013). Effect of
  667. Beyer WE.Fridovich I.(1987). Assaying for SOD activity some large consequences of minor changes in conditions. 161 :
  668. Devi Srilakshmi Kala S, Umakanthi V, Jayasudha M, Malleswari M, RavikanthSV and Jacob Doss P,(2013). Effect of
  669. Hagar HH, Fahmy AH, (2002). A biochemical, histochemical and ultrastructural evaluation of the effect of Dimethoate
  670. Aebi H, (1984). Catalase in vitro. Methods enzymol 105:121-6.
  671. Banerjee BD, Seth V.Ahmad RS.(2001). Pesticide – induced oxidative stress: perspective and trands. Rev environ health
  672. 559-66
  673. Aebi H, (1984). Catalase in vitro. Methods enzymol 105:121-6.
  674. intoxication on rat pancreass. Toxicol Lett 133:161-70.
  675. 559-66
  676. insecticides in urine for human bio monitoring in environmental medicine. Int J Hyg Environ Health, 209: 293-9.
  677. Aebi H, (1984). Catalase in vitro. Methods enzymol 105:121-6.
  678. 83.
  679. Heudorf U, ButteW, Schulz C, Angerer J, (2006). Reference values for metabolites of pyrethroid and organophosphorus
  680. Halliwell B, Guteride JMC, Cross CE, (1992). Free radicals, antioxidants and human disease: where we now? J Lab Clin
  681. De-Bleecker J, van-Den-Neucker K, Colradyn F, (1993).Intermediate syndromeinOrganophospharus poising: a prospective
  682. 83.
  683. Manna, S, BhattacharyyaD, MandalTKand Das S, (2005). Reported dose toxicity of Deltamethrin in rats. Indian journal of
  684. pharmacology, 37(3): 160-164.
  685. and brain of rats following subchronic exposure, Toxicology, 215: 2005b, p. 173-181.
  686. 83.
  687. Del Rio D, Stewart AJ, Pellegrini NA, (2005).review of recent studies on malonialdehyde as toxic molecule and biological
  688. Sharma Y, BashirS,Irshad M, DattaguptaS,Dogra, TD, (2005b.). Dimethoate- induced effects on antioxidant status of liver
  689. study. Crit Care Med 21(11): 1706-11.
  690. Beyer WE.Fridovich I.(1987). Assaying for SOD activity some large consequences of minor changes in conditions. 161 :
  691. Devi Srilakshmi Kala S, Umakanthi V, Jayasudha M, Malleswari M, RavikanthSV and Jacob Doss P,(2013). Effect of
  692. Manna, S, BhattacharyyaD, MandalTKand Das S, (2005). Reported dose toxicity of Deltamethrin in rats. Indian journal of
  693. pharmacology, 37(3): 160-164.
  694. and brain of rats following subchronic exposure, Toxicology, 215: 2005b, p. 173-181.
  695. Beyer WE.Fridovich I.(1987). Assaying for SOD activity some large consequences of minor changes in conditions. 161 :
  696. Devi Srilakshmi Kala S, Umakanthi V, Jayasudha M, Malleswari M, RavikanthSV and Jacob Doss P,(2013). Effect of
  697. Beyer WE.Fridovich I.(1987). Assaying for SOD activity some large consequences of minor changes in conditions. 161 :
  698. Devi Srilakshmi Kala S, Umakanthi V, Jayasudha M, Malleswari M, RavikanthSV and Jacob Doss P,(2013). Effect of
  699. Del Rio D, Stewart AJ, Pellegrini NA, (2005).review of recent studies on malonialdehyde as toxic molecule and biological
  700. Sharma Y, BashirS,Irshad M, DattaguptaS,Dogra, TD, (2005b.). Dimethoate- induced effects on antioxidant status of liver
  701. Toxicologic Pathology 59:237-243.
  702. Goetz ME, Luch A, (2008).Reactive species: a cell damaging rout assisting to chemical carcinogens. Cancer Lett 266: 73-
  703. Dimethoateon different regions of thebrain inAlbino rat. (In Press)
  704. intoxication on rat pancreass. Toxicol Lett 133:161-70.
  705. Cadet J, Bellon S, Berger M,Bourdat AG, Douki T,DuarteV, (2002). Recent aspects of oxidative DNA damage: guanine
  706. Dimethoateon different regions of thebrain inAlbino rat. (In Press)
  707. Beyer WE.Fridovich I.(1987). Assaying for SOD activity some large consequences of minor changes in conditions. 161 :
  708. Aebi H, (1984). Catalase in vitro. Methods enzymol 105:121-6.
  709. Del Rio D, Stewart AJ, Pellegrini NA, (2005).review of recent studies on malonialdehyde as toxic molecule and biological
  710. Sharma Y, BashirS,Irshad M, DattaguptaS,Dogra, TD, (2005b.). Dimethoate- induced effects on antioxidant status of liver
  711. Beyer WE.Fridovich I.(1987). Assaying for SOD activity some large consequences of minor changes in conditions. 161 :
  712. Devi Srilakshmi Kala S, Umakanthi V, Jayasudha M, Malleswari M, RavikanthSV and Jacob Doss P,(2013). Effect of
  713. Betrosian A, Balla M,Kafiri G,Kofinas G, Makri R,Kakouri A. (1995). Multiple systems organ failure from organophosphate
  714. Fridovich I, Beachamp,(1995). Superoxide radical and superoxide dismutases. Annu.Rev.Biochem, 64-97.
  715. Toxicologic Pathology 59:237-243.
  716. 83.
  717. Cadet J, Bellon S, Berger M,Bourdat AG, Douki T,DuarteV, (2002). Recent aspects of oxidative DNA damage: guanine
  718. 16:1.
  719. marker of oxidative stress. Nutr Metab Cardiovasc Dis 15:316-28.
  720. Banerjee BD, Seth V.Ahmad RS.(2001). Pesticide – induced oxidative stress: perspective and trands. Rev environ health
  721. Heudorf U, ButteW, Schulz C, Angerer J, (2006). Reference values for metabolites of pyrethroid and organophosphorus
  722. Hagar HH, Fahmy AH, (2002). A biochemical, histochemical and ultrastructural evaluation of the effect of Dimethoate
  723. 16:1.
  724. marker of oxidative stress. Nutr Metab Cardiovasc Dis 15:316-28.
  725. poising.J Toxicol Clin toxicol 33(3):257-60.
  726. lesions, measurement and substrate specificity of DNA repair glycosylases. Biol Chem 383:93
  727. 559-66
  728. insecticides in urine for human bio monitoring in environmental medicine. Int J Hyg Environ Health, 209: 293-9.
  729. Devi Srilakshmi Kala S, Umakanthi V, Jayasudha M, Malleswari M, RavikanthSV and Jacob Doss P,(2013). Effect of
  730. Hagar HH, Fahmy AH, (2002). A biochemical, histochemical and ultrastructural evaluation of the effect of Dimethoate
  731. Beyer WE.Fridovich I.(1987). Assaying for SOD activity some large consequences of minor changes in conditions. 161 :
  732. Devi Srilakshmi Kala S, Umakanthi V, Jayasudha M, Malleswari M, RavikanthSV and Jacob Doss P,(2013). Effect of
  733. intoxication on rat pancreass. Toxicol Lett 133:161-70.
  734. Goetz ME, Luch A, (2008).Reactive species: a cell damaging rout assisting to chemical carcinogens. Cancer Lett 266: 73-
  735. Beyer WE.Fridovich I.(1987). Assaying for SOD activity some large consequences of minor changes in conditions. 161 :
  736. Devi Srilakshmi Kala S, Umakanthi V, Jayasudha M, Malleswari M, RavikanthSV and Jacob Doss P,(2013). Effect of
  737. study. Crit Care Med 21(11): 1706-11.
  738. Beyer WE.Fridovich I.(1987). Assaying for SOD activity some large consequences of minor changes in conditions. 161 :
  739. Devi Srilakshmi Kala S, Umakanthi V, Jayasudha M, Malleswari M, RavikanthSV and Jacob Doss P,(2013). Effect of
  740. Halliwell B, Guteride JMC, Cross CE, (1992). Free radicals, antioxidants and human disease: where we now? J Lab Clin
  741. Betrosian A, Balla M,Kafiri G,Kofinas G, Makri R,Kakouri A. (1995). Multiple systems organ failure from organophosphate
  742. Dimethoateon different regions of thebrain inAlbino rat. (In Press)
  743. Betrosian A, Balla M,Kafiri G,Kofinas G, Makri R,Kakouri A. (1995). Multiple systems organ failure from organophosphate
  744. Fridovich I, Beachamp,(1995). Superoxide radical and superoxide dismutases. Annu.Rev.Biochem, 64-97.
  745. Fridovich I, Beachamp,(1995). Superoxide radical and superoxide dismutases. Annu.Rev.Biochem, 64-97.
  746. FerahSayim, (2007) Dimethoate-induced biochemical and histopathological changes in the liver of rats. Experimental and
  747. Med 119:598-620
  748. Banerjee BD, Seth V.Ahmad RS.(2001). Pesticide – induced oxidative stress: perspective and trands. Rev environ health
  749. Heudorf U, ButteW, Schulz C, Angerer J, (2006). Reference values for metabolites of pyrethroid and organophosphorus
  750. Beyer WE.Fridovich I.(1987). Assaying for SOD activity some large consequences of minor changes in conditions. 161 :
  751. Devi Srilakshmi Kala S, Umakanthi V, Jayasudha M, Malleswari M, RavikanthSV and Jacob Doss P,(2013). Effect of
  752. poising.J Toxicol Clin toxicol 33(3):257-60.
  753. lesions, measurement and substrate specificity of DNA repair glycosylases. Biol Chem 383:93
  754. Del Rio D, Stewart AJ, Pellegrini NA, (2005).review of recent studies on malonialdehyde as toxic molecule and biological
  755. Sharma Y, BashirS,Irshad M, DattaguptaS,Dogra, TD, (2005b.). Dimethoate- induced effects on antioxidant status of liver
  756. Dimethoateon different regions of thebrain inAlbino rat. (In Press)
  757. Dimethoateon different regions of thebrain inAlbino rat. (In Press)
  758. Cadet J, Bellon S, Berger M,Bourdat AG, Douki T,DuarteV, (2002). Recent aspects of oxidative DNA damage: guanine
  759. Beyer WE.Fridovich I.(1987). Assaying for SOD activity some large consequences of minor changes in conditions. 161 :
  760. Devi Srilakshmi Kala S, Umakanthi V, Jayasudha M, Malleswari M, RavikanthSV and Jacob Doss P,(2013). Effect of
  761. Beyer WE.Fridovich I.(1987). Assaying for SOD activity some large consequences of minor changes in conditions. 161 :
  762. Devi Srilakshmi Kala S, Umakanthi V, Jayasudha M, Malleswari M, RavikanthSV and Jacob Doss P,(2013). Effect of
  763. 16:1.
  764. marker of oxidative stress. Nutr Metab Cardiovasc Dis 15:316-28.
  765. Dimethoateon different regions of thebrain inAlbino rat. (In Press)
  766. Banerjee BD, Seth V.Ahmad RS.(2001). Pesticide – induced oxidative stress: perspective and trands. Rev environ health
  767. Heudorf U, ButteW, Schulz C, Angerer J, (2006). Reference values for metabolites of pyrethroid and organophosphorus
  768. 559-66
  769. insecticides in urine for human bio monitoring in environmental medicine. Int J Hyg Environ Health, 209: 293-9.
  770. Hagar HH, Fahmy AH, (2002). A biochemical, histochemical and ultrastructural evaluation of the effect of Dimethoate
  771. FerahSayim, (2007) Dimethoate-induced biochemical and histopathological changes in the liver of rats. Experimental and
  772. Med 119:598-620
  773. 559-66
  774. insecticides in urine for human bio monitoring in environmental medicine. Int J Hyg Environ Health, 209: 293-9.
  775. Del Rio D, Stewart AJ, Pellegrini NA, (2005).review of recent studies on malonialdehyde as toxic molecule and biological
  776. Cadet J, Bellon S, Berger M,Bourdat AG, Douki T,DuarteV, (2002). Recent aspects of oxidative DNA damage: guanine
  777. Sharma Y, BashirS,Irshad M, DattaguptaS,Dogra, TD, (2005b.). Dimethoate- induced effects on antioxidant status of liver
  778. De-Bleecker J, van-Den-Neucker K, Colradyn F, (1993).Intermediate syndromeinOrganophospharus poising: a prospective
  779. Fridovich I, Beachamp,(1995). Superoxide radical and superoxide dismutases. Annu.Rev.Biochem, 64-97.
  780. 83.
  781. Aebi H, (1984). Catalase in vitro. Methods enzymol 105:121-6.
  782. poising.J Toxicol Clin toxicol 33(3):257-60.
  783. lesions, measurement and substrate specificity of DNA repair glycosylases. Biol Chem 383:93
  784. FerahSayim, (2007) Dimethoate-induced biochemical and histopathological changes in the liver of rats. Experimental and
  785. Med 119:598-620
  786. Cadet J, Bellon S, Berger M,Bourdat AG, Douki T,DuarteV, (2002). Recent aspects of oxidative DNA damage: guanine
  787. Hagar HH, Fahmy AH, (2002). A biochemical, histochemical and ultrastructural evaluation of the effect of Dimethoate
  788. Dimethoateon different regions of thebrain inAlbino rat. (In Press)
  789. Toxicologic Pathology 59:237-243.
  790. Goetz ME, Luch A, (2008).Reactive species: a cell damaging rout assisting to chemical carcinogens. Cancer Lett 266: 73-
  791. Beyer WE.Fridovich I.(1987). Assaying for SOD activity some large consequences of minor changes in conditions. 161 :
  792. Devi Srilakshmi Kala S, Umakanthi V, Jayasudha M, Malleswari M, RavikanthSV and Jacob Doss P,(2013). Effect of
  793. Betrosian A, Balla M,Kafiri G,Kofinas G, Makri R,Kakouri A. (1995). Multiple systems organ failure from organophosphate
  794. Aebi H, (1984). Catalase in vitro. Methods enzymol 105:121-6.
  795. Toxicologic Pathology 59:237-243.
  796. Goetz ME, Luch A, (2008).Reactive species: a cell damaging rout assisting to chemical carcinogens. Cancer Lett 266: 73-
  797. Betrosian A, Balla M,Kafiri G,Kofinas G, Makri R,Kakouri A. (1995). Multiple systems organ failure from organophosphate
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