Indian Streams Research Journal

Volume : XIV, Issue : XI, December - 2024

DETERMINATION OF METAL-LIGAND STABILITY CONSTANTS FOR LANTHANIDE (III) COMPLEXES WITH SUBSTITUTED DRUGS DERIVATIVES

R. S. Khedekar, G. B. Andhale

By : Laxmi Book Publication

Abstract :

The interactions of Ce(III), Pr(III), Nd(III), Sm(III), Gd(III), Dy(III), Yb(III), and Lu(III) metal ions with Oxymetazoline (6-tert-butyl-3-(4,5-dihydro-1H-imidazol-2-ylmethyl)-2,4-dimethylphenol) Ligand-1 and Amikacin ((2S)-4-amino-N-[(1R,2S,3S,4R,5S)-5-amino-2-[(2S,3R,4S,5S,6R)-4-amino-3,5-dihydroxy-6-(hydroxymethyl)oxan-2-yl]oxy-4-[(2R,3R,4S,5S,6R)-6-(aminomethyl)-3,4,5-trihydroxyoxan-2-yl]oxy-3-hydroxycyclohexyl]-2-hydroxybutanamide) Ligand-2 were systematically investigated using pH-metric techniques under controlled conditions at an ionic strength of 0.1 M and temperature ±0.1 °C in a 70% dioxane-water solvent system.

Keywords :

• Stability constant,
• Substituted drugs,
• Lanthanides (III),
• Metal-ligand stability,
• proton-ligand Stability.

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References :

1. 1. Trupti A Patekar, Abdul Rahim Shaikh, Int J Sci Res Sci & Technol. March-April 11 (15), 828-840, (2024), research gate.net.
2. 2. Vitaly Solov’ev, Natalia Kireeva, Svetlana Ovchinnikova, Aslan Tsivadze, Journal of Inclusion Phenomena and Macrocyclic Chemistry 83, 89-101, (2015), Springer.

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