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Volume : III, Issue : IV, May - 2013 SEQUENCE ANALYSIS AND HOMOLOGY MODELING OF SHANK3 PROTEIN INVOLVED IN AUTISM SHAMA N. MUJAWAR , VAIBHAV V. KANDALE AND PREETI J. WELASLY DOI : 10.9780/22307850, Published By : Laxmi Book Publication Abstract : Autism is a disorder of neural development characterized by impaired social
interaction and communication, and by restricted and repetitive behavior. Autism affects
information processing in the brain by altering how nerve cells and their synapses
connect and organize. Mutations in Shank3 gene are a cause of autism spectrum disorder
(ASD). SH3 and multiple ankyrin repeat domains 3 (Shank3), also known as proline-rich
synapse-associated protein 2 (ProSAP2), is a protein that in humans is encoded by the
SHANK3 gene on chromosome 22q13.3.Primary sequence analysis was done by using
ExPASy'sProtparam. Secondary structure was predicted using GOR4, SOPMA and
CFSSP. Homology modeling of Shank3 (Homo sapiens) protein was done by using
different tools and servers i.e. ESyPred3D, SWISS-MODEL server, EasyModeller and
Phyre2 and the four different structure were validated using Procheck. The project work
aims to build a potential model of shank3 protein which can be used for drug designing. Keywords : Article : Cite This Article : SHAMA N. MUJAWAR , VAIBHAV V. KANDALE AND PREETI J. WELASLY, (2013). SEQUENCE ANALYSIS AND HOMOLOGY MODELING OF SHANK3 PROTEIN INVOLVED IN AUTISM. Indian Streams Research Journal, Vol. III, Issue. IV, DOI : 10.9780/22307850, http://oldisrj.lbp.world/UploadedData/2345.pdf References : - Newschaffer CJ, Croen LA, Daniels J et al.the epidemiology of autism spectrum disorders 2007;
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