DOI Prefix : 10.9780 | Journal DOI : 10.9780/22307850
Scroll to Top

Volume : IV, Issue : II, March - 2014

IMPACT OF CURCUMIN ON NICOTINE-INDUCED LUNG CHANGE: HISTOPATHOLOGICAL, BIOCHEMICAL AND IMMUNOLOGICAL STUDY

Sawsan H. Karam, Anisa S. Mohamed, Sahar M. Mansour, Heba I. Issa, Amany Abdel Ghaffar, Atef M. Mahmoud and Seham Abdel Dayem

DOI : 10.9780/22307850, By : Laxmi Book Publication

Abstract :

Background: Nicotine, major toxic component of cigarette smoke, is considered to be the main risk factor in the development of pulmonary diseases Purpose: The aim of the present study was to investigate the morphological, biochemical and immunological changes in albino rats following intraperitoneal injection of nicotine. The possible protective effect of curcumin was also evaluated. Material and Methods: The study included three groups, the first served as control. The second was injected with nicotine (2.5mg/ kg body weigh) for eight weeks. The third group was injected with nicotine as the second group in addition to curcumin (80mg/kg body weight) for also eight weeks. Results: Injection with nicotine resulted in replacement of air sacs in lung tissue by connective tissue full of large number of inflammatory cells and red cells. Respiratory bronchioles were disrupted and their lumen was closed with acidophilic material. Biochemically increased Malondialdehyde (MA) and nitric oxide (NO) and decreased reduced glutathione (GSH), superoxide dismutase (SOD) and catalase (Ca) were documented. Immunologically, nicotine was an important immuno-suppressive constituent of cigarette smoke. The previous results were improved in curcumine treated group indicating its protective role against the oxidative stress .Conclusion: We concluded that, consumption of curcumine to smokers can protect against lung hazards.

Keywords :


Article :


Cite This Article :

Sawsan H. Karam, Anisa S. Mohamed, Sahar M. Mansour, Heba I. Issa, Amany Abdel Ghaffar, Atef M. Mahmoud and Seham Abdel Dayem(2014). IMPACT OF CURCUMIN ON NICOTINE-INDUCED LUNG CHANGE: HISTOPATHOLOGICAL, BIOCHEMICAL AND IMMUNOLOGICAL STUDY. Indian Streams Research Journal, Vol. IV, Issue. II, DOI : 10.9780/22307850, http://isrj.org/UploadedData/4385.pdf

References :

  1. Nurs., 7: 241-255
  2. Biochem. Pharmacol., 75(4): 787-809.
  3. 357: 593-615.
  4. Ogna, A. Noirez L. Lazor R. and Nicod L.P. 2012. Respiratory brochiolitis and respiratory brochiolitis-associated
  5. interstitial lung disease. Rev. Med. Suisse, 21(8): 2228-2232.
  6. Alderton, W.K., Cooper C.E. and Knowles R.G. 2001. Nitric oxide synthases: structure, function and inhibition. Biochem. J.,
  7. Kalpana, C. and Menon V.P. 2004. Inhibition of nicotine-induced toxicity by curcumin and curcumin analog: a comparative
  8. 537-544.
  9. Biochem., 95: 351-358.
  10. Convenient Assay for Superoxide Dismutase. Eur. J. Biochem., 47: 469-474
  11. Choi, J., Hoffman L.A., Rodway G.W. and Sethi J.M. 2006. Markers of lung disease in exhaled breath: nitric oxide. Biol. Res.
  12. Nurs., 7: 241-255
  13. Convenient Assay for Superoxide Dismutase. Eur. J. Biochem., 47: 469-474
  14. Choi, J., Hoffman L.A., Rodway G.W. and Sethi J.M. 2006. Markers of lung disease in exhaled breath: nitric oxide. Biol. Res.
  15. Lowry, O.H. Rosebrough N.J. Farr, A.L., Randall, R.J. 1951. Protein measurement with the Folin phenol reagent. J. Biol.
  16. Convenient Assay for Superoxide Dismutase. Eur. J. Biochem., 47: 469-474
  17. Choi, J., Hoffman L.A., Rodway G.W. and Sethi J.M. 2006. Markers of lung disease in exhaled breath: nitric oxide. Biol. Res.
  18. Marklund, S. and Marklund G. 1974. Involvement of the Superoxide Anion Radical in the Autoxidation of Pyrogallol and a
  19. Lowry, O.H. Rosebrough N.J. Farr, A.L., Randall, R.J. 1951. Protein measurement with the Folin phenol reagent. J. Biol.
  20. Kalpana, C., Sudheer A.R., Rajasekharan K.N. and Menon V.P. 2007. Comparative effects of curcumin and its synthetic
  21. Lepovire, M., Chenais B. and Yapo Al. 1990. Alterations of ribonucleotide reductase activity following induction of nitritegenerating
  22. Marklund, S. and Marklund G. 1974. Involvement of the Superoxide Anion Radical in the Autoxidation of Pyrogallol and a
  23. Kalpana, C., Sudheer A.R., Rajasekharan K.N. and Menon V.P. 2007. Comparative effects of curcumin and its synthetic
  24. Ellman, G.L. 1959. Tissue sulfhydryl groups. Arch. Biochem. Biophys, 82: 70–77.
  25. study. J. Med. Food, 7: 467-471
  26. 129
  27. Nurs., 7: 241-255
  28. Kalpana, C., Sudheer A.R., Rajasekharan K.N. and Menon V.P. 2007. Comparative effects of curcumin and its synthetic
  29. Ajay, Goel Ajaikumar, B.K. unnumakkara and Bhaarat B. Aggarwal. 2008. Curcumin as (curcumin): Fromm kitchen to
  30. clinic.
  31. Nurs., 7: 241-255
  32. induced inhibition of cellular reactive oxygen species generation: novel therapeutic implications. J. Biosci., 28: 715–721.
  33. induced inhibition of cellular reactive oxygen species generation: novel therapeutic implications. J. Biosci., 28: 715–721.
  34. Dicke, K.E., Skrlin S.M. and Murphy S.E. 2005. Nicotine and 4-(methylnitrosamino)-1-(3-pyridyl)-butanone metabolism
  35. protect alcohol-induced liver damage by modulation of the alcohol metabolic pathway, CYP2E1 and AMPK. Life Sci., 13(2):
  36. Ohkawa, H.; Ohishi N. and Yagi, K. 1979. Assay for lipid peroxides in animal tissues by thiobarbituric acid reaction. Anal.
  37. Nurs., 7: 241-255
  38. Lowry, O.H. Rosebrough N.J. Farr, A.L., Randall, R.J. 1951. Protein measurement with the Folin phenol reagent. J. Biol.
  39. Lee, H.I., Mc Gregor R.A., Choi M.S., Seo K.I., Jung U.J., Yeo J., Kim M.J. and Lee M.K. 2013. Low doses of curcumin
  40. study. J. Med. Food, 7: 467-471
  41. Lowry, O.H. Rosebrough N.J. Farr, A.L., Randall, R.J. 1951. Protein measurement with the Folin phenol reagent. J. Biol.
  42. analogue on tissue lipid peroxidation and antioxidant status during nicotine-induced toxicity. Singapore Med. J., 48(2): 124-
  43. pathway in adenocarcinoma cells. J. Biol. Chem., 265: 14143-14149
  44. Chem., 193: 265-275
  45. Alderton, W.K., Cooper C.E. and Knowles R.G. 2001. Nitric oxide synthases: structure, function and inhibition. Biochem. J.,
  46. Kalpana, C. and Menon V.P. 2004. Inhibition of nicotine-induced toxicity by curcumin and curcumin analog: a comparative
  47. 537-544.
  48. Biochem., 95: 351-358.
  49. analogue on tissue lipid peroxidation and antioxidant status during nicotine-induced toxicity. Singapore Med. J., 48(2): 124-
  50. pathway in adenocarcinoma cells. J. Biol. Chem., 265: 14143-14149
  51. Chem., 193: 265-275
  52. Alderton, W.K., Cooper C.E. and Knowles R.G. 2001. Nitric oxide synthases: structure, function and inhibition. Biochem. J.,
  53. Kalpana, C. and Menon V.P. 2004. Inhibition of nicotine-induced toxicity by curcumin and curcumin analog: a comparative
  54. 537-544.
  55. Biochem., 95: 351-358.
  56. induced inhibition of cellular reactive oxygen species generation: novel therapeutic implications. J. Biosci., 28: 715–721.
  57. Lepovire, M., Chenais B. and Yapo Al. 1990. Alterations of ribonucleotide reductase activity following induction of nitritegenerating
  58. Marklund, S. and Marklund G. 1974. Involvement of the Superoxide Anion Radical in the Autoxidation of Pyrogallol and a
  59. Nurs., 7: 241-255
  60. Ellman, G.L. 1959. Tissue sulfhydryl groups. Arch. Biochem. Biophys, 82: 70–77.
  61. study. J. Med. Food, 7: 467-471
  62. Ajay, Goel Ajaikumar, B.K. unnumakkara and Bhaarat B. Aggarwal. 2008. Curcumin as (curcumin): Fromm kitchen to
  63. clinic.
  64. Nurs., 7: 241-255
  65. analogue on tissue lipid peroxidation and antioxidant status during nicotine-induced toxicity. Singapore Med. J., 48(2): 124-
  66. pathway in adenocarcinoma cells. J. Biol. Chem., 265: 14143-14149
  67. Chem., 193: 265-275
  68. Alderton, W.K., Cooper C.E. and Knowles R.G. 2001. Nitric oxide synthases: structure, function and inhibition. Biochem. J.,
  69. Kalpana, C. and Menon V.P. 2004. Inhibition of nicotine-induced toxicity by curcumin and curcumin analog: a comparative
  70. 537-544.
  71. Biochem., 95: 351-358.
  72. Lepovire, M., Chenais B. and Yapo Al. 1990. Alterations of ribonucleotide reductase activity following induction of nitritegenerating
  73. Marklund, S. and Marklund G. 1974. Involvement of the Superoxide Anion Radical in the Autoxidation of Pyrogallol and a
  74. Biochem. Pharmacol., 75(4): 787-809.
  75. 357: 593-615.
  76. Ogna, A. Noirez L. Lazor R. and Nicod L.P. 2012. Respiratory brochiolitis and respiratory brochiolitis-associated
  77. interstitial lung disease. Rev. Med. Suisse, 21(8): 2228-2232.
  78. Kalpana, C., Sudheer A.R., Rajasekharan K.N. and Menon V.P. 2007. Comparative effects of curcumin and its synthetic
  79. Lepovire, M., Chenais B. and Yapo Al. 1990. Alterations of ribonucleotide reductase activity following induction of nitritegenerating
  80. Marklund, S. and Marklund G. 1974. Involvement of the Superoxide Anion Radical in the Autoxidation of Pyrogallol and a
  81. Convenient Assay for Superoxide Dismutase. Eur. J. Biochem., 47: 469-474
  82. Choi, J., Hoffman L.A., Rodway G.W. and Sethi J.M. 2006. Markers of lung disease in exhaled breath: nitric oxide. Biol. Res.
  83. Nurs., 7: 241-255
  84. protect alcohol-induced liver damage by modulation of the alcohol metabolic pathway, CYP2E1 and AMPK. Life Sci., 13(2):
  85. Ohkawa, H.; Ohishi N. and Yagi, K. 1979. Assay for lipid peroxides in animal tissues by thiobarbituric acid reaction. Anal.
  86. by cytochrome P450 2B6. Drug Metab. Dispos., 33: 1760-1764.
  87. Balasubramanyam, M., Koteswari A.A., Kumar R.S., Monickaraj S.F., Maheswari J.U. and Mohan V. 2003. Curcumin
  88. induced inhibition of cellular reactive oxygen species generation: novel therapeutic implications. J. Biosci., 28: 715–721.
  89. induced inhibition of cellular reactive oxygen species generation: novel therapeutic implications. J. Biosci., 28: 715–721.
  90. analogue on tissue lipid peroxidation and antioxidant status during nicotine-induced toxicity. Singapore Med. J., 48(2): 124-
  91. pathway in adenocarcinoma cells. J. Biol. Chem., 265: 14143-14149
  92. Chem., 193: 265-275
  93. Ellman, G.L. 1959. Tissue sulfhydryl groups. Arch. Biochem. Biophys, 82: 70–77.
  94. Nurs., 7: 241-255
  95. Lepovire, M., Chenais B. and Yapo Al. 1990. Alterations of ribonucleotide reductase activity following induction of nitritegenerating
  96. Marklund, S. and Marklund G. 1974. Involvement of the Superoxide Anion Radical in the Autoxidation of Pyrogallol and a
  97. Nurs., 7: 241-255
  98. Kalpana, C., Sudheer A.R., Rajasekharan K.N. and Menon V.P. 2007. Comparative effects of curcumin and its synthetic
  99. induced inhibition of cellular reactive oxygen species generation: novel therapeutic implications. J. Biosci., 28: 715–721.
  100. Nurs., 7: 241-255
  101. Ajay, Goel Ajaikumar, B.K. unnumakkara and Bhaarat B. Aggarwal. 2008. Curcumin as (curcumin): Fromm kitchen to
  102. clinic.
  103. Lowry, O.H. Rosebrough N.J. Farr, A.L., Randall, R.J. 1951. Protein measurement with the Folin phenol reagent. J. Biol.
  104. Ajay, Goel Ajaikumar, B.K. unnumakkara and Bhaarat B. Aggarwal. 2008. Curcumin as (curcumin): Fromm kitchen to
  105. clinic.
  106. protect alcohol-induced liver damage by modulation of the alcohol metabolic pathway, CYP2E1 and AMPK. Life Sci., 13(2):
  107. Dicke, K.E., Skrlin S.M. and Murphy S.E. 2005. Nicotine and 4-(methylnitrosamino)-1-(3-pyridyl)-butanone metabolism
  108. Lee, H.I., Mc Gregor R.A., Choi M.S., Seo K.I., Jung U.J., Yeo J., Kim M.J. and Lee M.K. 2013. Low doses of curcumin
  109. Biochem. Pharmacol., 75(4): 787-809.
  110. 357: 593-615.
  111. Ogna, A. Noirez L. Lazor R. and Nicod L.P. 2012. Respiratory brochiolitis and respiratory brochiolitis-associated
  112. interstitial lung disease. Rev. Med. Suisse, 21(8): 2228-2232.
  113. protect alcohol-induced liver damage by modulation of the alcohol metabolic pathway, CYP2E1 and AMPK. Life Sci., 13(2):
  114. Ohkawa, H.; Ohishi N. and Yagi, K. 1979. Assay for lipid peroxides in animal tissues by thiobarbituric acid reaction. Anal.
  115. Lowry, O.H. Rosebrough N.J. Farr, A.L., Randall, R.J. 1951. Protein measurement with the Folin phenol reagent. J. Biol.
  116. Nurs., 7: 241-255
  117. Ohkawa, H.; Ohishi N. and Yagi, K. 1979. Assay for lipid peroxides in animal tissues by thiobarbituric acid reaction. Anal.
  118. Ajay, Goel Ajaikumar, B.K. unnumakkara and Bhaarat B. Aggarwal. 2008. Curcumin as (curcumin): Fromm kitchen to
  119. clinic.
  120. Dicke, K.E., Skrlin S.M. and Murphy S.E. 2005. Nicotine and 4-(methylnitrosamino)-1-(3-pyridyl)-butanone metabolism
  121. induced inhibition of cellular reactive oxygen species generation: novel therapeutic implications. J. Biosci., 28: 715–721.
  122. Dicke, K.E., Skrlin S.M. and Murphy S.E. 2005. Nicotine and 4-(methylnitrosamino)-1-(3-pyridyl)-butanone metabolism
  123. Lee, H.I., Mc Gregor R.A., Choi M.S., Seo K.I., Jung U.J., Yeo J., Kim M.J. and Lee M.K. 2013. Low doses of curcumin
  124. protect alcohol-induced liver damage by modulation of the alcohol metabolic pathway, CYP2E1 and AMPK. Life Sci., 13(2):
  125. Ohkawa, H.; Ohishi N. and Yagi, K. 1979. Assay for lipid peroxides in animal tissues by thiobarbituric acid reaction. Anal.
  126. Alderton, W.K., Cooper C.E. and Knowles R.G. 2001. Nitric oxide synthases: structure, function and inhibition. Biochem. J.,
  127. Kalpana, C. and Menon V.P. 2004. Inhibition of nicotine-induced toxicity by curcumin and curcumin analog: a comparative
  128. 537-544.
  129. Biochem., 95: 351-358.
  130. Ajay, Goel Ajaikumar, B.K. unnumakkara and Bhaarat B. Aggarwal. 2008. Curcumin as (curcumin): Fromm kitchen to
  131. clinic.
  132. Ajay, Goel Ajaikumar, B.K. unnumakkara and Bhaarat B. Aggarwal. 2008. Curcumin as (curcumin): Fromm kitchen to
  133. clinic.
  134. study. J. Med. Food, 7: 467-471
  135. Ellman, G.L. 1959. Tissue sulfhydryl groups. Arch. Biochem. Biophys, 82: 70–77.
  136. Biochem. Pharmacol., 75(4): 787-809.
  137. 357: 593-615.
  138. Ogna, A. Noirez L. Lazor R. and Nicod L.P. 2012. Respiratory brochiolitis and respiratory brochiolitis-associated
  139. interstitial lung disease. Rev. Med. Suisse, 21(8): 2228-2232.
  140. Lepovire, M., Chenais B. and Yapo Al. 1990. Alterations of ribonucleotide reductase activity following induction of nitritegenerating
  141. Marklund, S. and Marklund G. 1974. Involvement of the Superoxide Anion Radical in the Autoxidation of Pyrogallol and a
  142. protect alcohol-induced liver damage by modulation of the alcohol metabolic pathway, CYP2E1 and AMPK. Life Sci., 13(2):
  143. Ohkawa, H.; Ohishi N. and Yagi, K. 1979. Assay for lipid peroxides in animal tissues by thiobarbituric acid reaction. Anal.
  144. by cytochrome P450 2B6. Drug Metab. Dispos., 33: 1760-1764.
  145. Balasubramanyam, M., Koteswari A.A., Kumar R.S., Monickaraj S.F., Maheswari J.U. and Mohan V. 2003. Curcumin
  146. by cytochrome P450 2B6. Drug Metab. Dispos., 33: 1760-1764.
  147. Balasubramanyam, M., Koteswari A.A., Kumar R.S., Monickaraj S.F., Maheswari J.U. and Mohan V. 2003. Curcumin
  148. study. J. Med. Food, 7: 467-471
  149. Ajay, Goel Ajaikumar, B.K. unnumakkara and Bhaarat B. Aggarwal. 2008. Curcumin as (curcumin): Fromm kitchen to
  150. clinic.
  151. analogue on tissue lipid peroxidation and antioxidant status during nicotine-induced toxicity. Singapore Med. J., 48(2): 124-
  152. pathway in adenocarcinoma cells. J. Biol. Chem., 265: 14143-14149
  153. Chem., 193: 265-275
  154. 129
  155. Ajay, Goel Ajaikumar, B.K. unnumakkara and Bhaarat B. Aggarwal. 2008. Curcumin as (curcumin): Fromm kitchen to
  156. clinic.
  157. protect alcohol-induced liver damage by modulation of the alcohol metabolic pathway, CYP2E1 and AMPK. Life Sci., 13(2):
  158. Ohkawa, H.; Ohishi N. and Yagi, K. 1979. Assay for lipid peroxides in animal tissues by thiobarbituric acid reaction. Anal.
  159. Ellman, G.L. 1959. Tissue sulfhydryl groups. Arch. Biochem. Biophys, 82: 70–77.
  160. Nurs., 7: 241-255
  161. Lepovire, M., Chenais B. and Yapo Al. 1990. Alterations of ribonucleotide reductase activity following induction of nitritegenerating
  162. analogue on tissue lipid peroxidation and antioxidant status during nicotine-induced toxicity. Singapore Med. J., 48(2): 124-
  163. pathway in adenocarcinoma cells. J. Biol. Chem., 265: 14143-14149
  164. Chem., 193: 265-275
  165. Lepovire, M., Chenais B. and Yapo Al. 1990. Alterations of ribonucleotide reductase activity following induction of nitritegenerating
  166. Biochem. Pharmacol., 75(4): 787-809.
  167. 357: 593-615.
  168. Ogna, A. Noirez L. Lazor R. and Nicod L.P. 2012. Respiratory brochiolitis and respiratory brochiolitis-associated
  169. interstitial lung disease. Rev. Med. Suisse, 21(8): 2228-2232.
  170. Dicke, K.E., Skrlin S.M. and Murphy S.E. 2005. Nicotine and 4-(methylnitrosamino)-1-(3-pyridyl)-butanone metabolism
  171. Lowry, O.H. Rosebrough N.J. Farr, A.L., Randall, R.J. 1951. Protein measurement with the Folin phenol reagent. J. Biol.
  172. Marklund, S. and Marklund G. 1974. Involvement of the Superoxide Anion Radical in the Autoxidation of Pyrogallol and a
  173. Marklund, S. and Marklund G. 1974. Involvement of the Superoxide Anion Radical in the Autoxidation of Pyrogallol and a
  174. Nurs., 7: 241-255
  175. Dicke, K.E., Skrlin S.M. and Murphy S.E. 2005. Nicotine and 4-(methylnitrosamino)-1-(3-pyridyl)-butanone metabolism
  176. Kalpana, C. and Menon V.P. 2004. Inhibition of nicotine-induced toxicity by curcumin and curcumin analog: a comparative
  177. 537-544.
  178. Biochem., 95: 351-358.
  179. Biochem. Pharmacol., 75(4): 787-809.
  180. 357: 593-615.
  181. Ogna, A. Noirez L. Lazor R. and Nicod L.P. 2012. Respiratory brochiolitis and respiratory brochiolitis-associated
  182. interstitial lung disease. Rev. Med. Suisse, 21(8): 2228-2232.
  183. Nurs., 7: 241-255
  184. Lepovire, M., Chenais B. and Yapo Al. 1990. Alterations of ribonucleotide reductase activity following induction of nitritegenerating
  185. Marklund, S. and Marklund G. 1974. Involvement of the Superoxide Anion Radical in the Autoxidation of Pyrogallol and a
  186. analogue on tissue lipid peroxidation and antioxidant status during nicotine-induced toxicity. Singapore Med. J., 48(2): 124-
  187. study. J. Med. Food, 7: 467-471
  188. Alderton, W.K., Cooper C.E. and Knowles R.G. 2001. Nitric oxide synthases: structure, function and inhibition. Biochem. J.,
  189. Kalpana, C. and Menon V.P. 2004. Inhibition of nicotine-induced toxicity by curcumin and curcumin analog: a comparative
  190. 537-544.
  191. Biochem., 95: 351-358.
  192. Alderton, W.K., Cooper C.E. and Knowles R.G. 2001. Nitric oxide synthases: structure, function and inhibition. Biochem. J.,
  193. Kalpana, C. and Menon V.P. 2004. Inhibition of nicotine-induced toxicity by curcumin and curcumin analog: a comparative
  194. 537-544.
  195. Biochem., 95: 351-358.
  196. Convenient Assay for Superoxide Dismutase. Eur. J. Biochem., 47: 469-474
  197. Choi, J., Hoffman L.A., Rodway G.W. and Sethi J.M. 2006. Markers of lung disease in exhaled breath: nitric oxide. Biol. Res.
  198. pathway in adenocarcinoma cells. J. Biol. Chem., 265: 14143-14149
  199. Chem., 193: 265-275
  200. Alderton, W.K., Cooper C.E. and Knowles R.G. 2001. Nitric oxide synthases: structure, function and inhibition. Biochem. J.,
  201. Lee, H.I., Mc Gregor R.A., Choi M.S., Seo K.I., Jung U.J., Yeo J., Kim M.J. and Lee M.K. 2013. Low doses of curcumin
  202. protect alcohol-induced liver damage by modulation of the alcohol metabolic pathway, CYP2E1 and AMPK. Life Sci., 13(2):
  203. 129
  204. 357: 593-615.
  205. Ogna, A. Noirez L. Lazor R. and Nicod L.P. 2012. Respiratory brochiolitis and respiratory brochiolitis-associated
  206. interstitial lung disease. Rev. Med. Suisse, 21(8): 2228-2232.
  207. Choi, J., Hoffman L.A., Rodway G.W. and Sethi J.M. 2006. Markers of lung disease in exhaled breath: nitric oxide. Biol. Res.
  208. Convenient Assay for Superoxide Dismutase. Eur. J. Biochem., 47: 469-474
  209. Choi, J., Hoffman L.A., Rodway G.W. and Sethi J.M. 2006. Markers of lung disease in exhaled breath: nitric oxide. Biol. Res.
  210. Alderton, W.K., Cooper C.E. and Knowles R.G. 2001. Nitric oxide synthases: structure, function and inhibition. Biochem. J.,
  211. Kalpana, C. and Menon V.P. 2004. Inhibition of nicotine-induced toxicity by curcumin and curcumin analog: a comparative
  212. 537-544.
  213. Biochem., 95: 351-358.
  214. Alderton, W.K., Cooper C.E. and Knowles R.G. 2001. Nitric oxide synthases: structure, function and inhibition. Biochem. J.,
  215. Kalpana, C. and Menon V.P. 2004. Inhibition of nicotine-induced toxicity by curcumin and curcumin analog: a comparative
  216. 537-544.
  217. Biochem., 95: 351-358.
  218. Convenient Assay for Superoxide Dismutase. Eur. J. Biochem., 47: 469-474
  219. Choi, J., Hoffman L.A., Rodway G.W. and Sethi J.M. 2006. Markers of lung disease in exhaled breath: nitric oxide. Biol. Res.
  220. Dicke, K.E., Skrlin S.M. and Murphy S.E. 2005. Nicotine and 4-(methylnitrosamino)-1-(3-pyridyl)-butanone metabolism
  221. Lee, H.I., Mc Gregor R.A., Choi M.S., Seo K.I., Jung U.J., Yeo J., Kim M.J. and Lee M.K. 2013. Low doses of curcumin
  222. protect alcohol-induced liver damage by modulation of the alcohol metabolic pathway, CYP2E1 and AMPK. Life Sci., 13(2):
  223. Ohkawa, H.; Ohishi N. and Yagi, K. 1979. Assay for lipid peroxides in animal tissues by thiobarbituric acid reaction. Anal.
  224. 129
  225. Alderton, W.K., Cooper C.E. and Knowles R.G. 2001. Nitric oxide synthases: structure, function and inhibition. Biochem. J.,
  226. Kalpana, C. and Menon V.P. 2004. Inhibition of nicotine-induced toxicity by curcumin and curcumin analog: a comparative
  227. 537-544.
  228. Biochem., 95: 351-358.
  229. Biochem. Pharmacol., 75(4): 787-809.
  230. 357: 593-615.
  231. Ogna, A. Noirez L. Lazor R. and Nicod L.P. 2012. Respiratory brochiolitis and respiratory brochiolitis-associated
  232. interstitial lung disease. Rev. Med. Suisse, 21(8): 2228-2232.
  233. Ohkawa, H.; Ohishi N. and Yagi, K. 1979. Assay for lipid peroxides in animal tissues by thiobarbituric acid reaction. Anal.
  234. Ellman, G.L. 1959. Tissue sulfhydryl groups. Arch. Biochem. Biophys, 82: 70–77.
  235. by cytochrome P450 2B6. Drug Metab. Dispos., 33: 1760-1764.
  236. Balasubramanyam, M., Koteswari A.A., Kumar R.S., Monickaraj S.F., Maheswari J.U. and Mohan V. 2003. Curcumin
  237. Ajay, Goel Ajaikumar, B.K. unnumakkara and Bhaarat B. Aggarwal. 2008. Curcumin as (curcumin): Fromm kitchen to
  238. clinic.
  239. by cytochrome P450 2B6. Drug Metab. Dispos., 33: 1760-1764.
  240. Balasubramanyam, M., Koteswari A.A., Kumar R.S., Monickaraj S.F., Maheswari J.U. and Mohan V. 2003. Curcumin
  241. Ellman, G.L. 1959. Tissue sulfhydryl groups. Arch. Biochem. Biophys, 82: 70–77.
  242. Nurs., 7: 241-255
  243. Biochem. Pharmacol., 75(4): 787-809.
  244. Convenient Assay for Superoxide Dismutase. Eur. J. Biochem., 47: 469-474
  245. induced inhibition of cellular reactive oxygen species generation: novel therapeutic implications. J. Biosci., 28: 715–721.
  246. Lepovire, M., Chenais B. and Yapo Al. 1990. Alterations of ribonucleotide reductase activity following induction of nitritegenerating
  247. Marklund, S. and Marklund G. 1974. Involvement of the Superoxide Anion Radical in the Autoxidation of Pyrogallol and a
  248. Dicke, K.E., Skrlin S.M. and Murphy S.E. 2005. Nicotine and 4-(methylnitrosamino)-1-(3-pyridyl)-butanone metabolism
  249. Alderton, W.K., Cooper C.E. and Knowles R.G. 2001. Nitric oxide synthases: structure, function and inhibition. Biochem. J.,
  250. Kalpana, C. and Menon V.P. 2004. Inhibition of nicotine-induced toxicity by curcumin and curcumin analog: a comparative
  251. 537-544.
  252. Biochem., 95: 351-358.
  253. Ellman, G.L. 1959. Tissue sulfhydryl groups. Arch. Biochem. Biophys, 82: 70–77.
  254. Lee, H.I., Mc Gregor R.A., Choi M.S., Seo K.I., Jung U.J., Yeo J., Kim M.J. and Lee M.K. 2013. Low doses of curcumin
  255. Lowry, O.H. Rosebrough N.J. Farr, A.L., Randall, R.J. 1951. Protein measurement with the Folin phenol reagent. J. Biol.
  256. Dicke, K.E., Skrlin S.M. and Murphy S.E. 2005. Nicotine and 4-(methylnitrosamino)-1-(3-pyridyl)-butanone metabolism
  257. protect alcohol-induced liver damage by modulation of the alcohol metabolic pathway, CYP2E1 and AMPK. Life Sci., 13(2):
  258. Ohkawa, H.; Ohishi N. and Yagi, K. 1979. Assay for lipid peroxides in animal tissues by thiobarbituric acid reaction. Anal.
  259. Lee, H.I., Mc Gregor R.A., Choi M.S., Seo K.I., Jung U.J., Yeo J., Kim M.J. and Lee M.K. 2013. Low doses of curcumin
  260. analogue on tissue lipid peroxidation and antioxidant status during nicotine-induced toxicity. Singapore Med. J., 48(2): 124-
  261. pathway in adenocarcinoma cells. J. Biol. Chem., 265: 14143-14149
  262. Chem., 193: 265-275
  263. Alderton, W.K., Cooper C.E. and Knowles R.G. 2001. Nitric oxide synthases: structure, function and inhibition. Biochem. J.,
  264. Kalpana, C. and Menon V.P. 2004. Inhibition of nicotine-induced toxicity by curcumin and curcumin analog: a comparative
  265. 537-544.
  266. Biochem., 95: 351-358.
  267. 357: 593-615.
  268. Ogna, A. Noirez L. Lazor R. and Nicod L.P. 2012. Respiratory brochiolitis and respiratory brochiolitis-associated
  269. interstitial lung disease. Rev. Med. Suisse, 21(8): 2228-2232.
  270. analogue on tissue lipid peroxidation and antioxidant status during nicotine-induced toxicity. Singapore Med. J., 48(2): 124-
  271. pathway in adenocarcinoma cells. J. Biol. Chem., 265: 14143-14149
  272. Chem., 193: 265-275
  273. 129
  274. Alderton, W.K., Cooper C.E. and Knowles R.G. 2001. Nitric oxide synthases: structure, function and inhibition. Biochem. J.,
  275. Kalpana, C. and Menon V.P. 2004. Inhibition of nicotine-induced toxicity by curcumin and curcumin analog: a comparative
  276. 537-544.
  277. Biochem., 95: 351-358.
  278. Ajay, Goel Ajaikumar, B.K. unnumakkara and Bhaarat B. Aggarwal. 2008. Curcumin as (curcumin): Fromm kitchen to
  279. clinic.
  280. protect alcohol-induced liver damage by modulation of the alcohol metabolic pathway, CYP2E1 and AMPK. Life Sci., 13(2):
  281. Ohkawa, H.; Ohishi N. and Yagi, K. 1979. Assay for lipid peroxides in animal tissues by thiobarbituric acid reaction. Anal.
  282. Lowry, O.H. Rosebrough N.J. Farr, A.L., Randall, R.J. 1951. Protein measurement with the Folin phenol reagent. J. Biol.
  283. Biochem. Pharmacol., 75(4): 787-809.
  284. Biochem. Pharmacol., 75(4): 787-809.
  285. 357: 593-615.
  286. Ogna, A. Noirez L. Lazor R. and Nicod L.P. 2012. Respiratory brochiolitis and respiratory brochiolitis-associated
  287. interstitial lung disease. Rev. Med. Suisse, 21(8): 2228-2232.
  288. induced inhibition of cellular reactive oxygen species generation: novel therapeutic implications. J. Biosci., 28: 715–721.
  289. Lee, H.I., Mc Gregor R.A., Choi M.S., Seo K.I., Jung U.J., Yeo J., Kim M.J. and Lee M.K. 2013. Low doses of curcumin
  290. by cytochrome P450 2B6. Drug Metab. Dispos., 33: 1760-1764.
  291. by cytochrome P450 2B6. Drug Metab. Dispos., 33: 1760-1764.
  292. Balasubramanyam, M., Koteswari A.A., Kumar R.S., Monickaraj S.F., Maheswari J.U. and Mohan V. 2003. Curcumin
  293. Convenient Assay for Superoxide Dismutase. Eur. J. Biochem., 47: 469-474
  294. Choi, J., Hoffman L.A., Rodway G.W. and Sethi J.M. 2006. Markers of lung disease in exhaled breath: nitric oxide. Biol. Res.
  295. analogue on tissue lipid peroxidation and antioxidant status during nicotine-induced toxicity. Singapore Med. J., 48(2): 124-
  296. pathway in adenocarcinoma cells. J. Biol. Chem., 265: 14143-14149
  297. Chem., 193: 265-275
  298. Lee, H.I., Mc Gregor R.A., Choi M.S., Seo K.I., Jung U.J., Yeo J., Kim M.J. and Lee M.K. 2013. Low doses of curcumin
  299. Kalpana, C., Sudheer A.R., Rajasekharan K.N. and Menon V.P. 2007. Comparative effects of curcumin and its synthetic
  300. Ellman, G.L. 1959. Tissue sulfhydryl groups. Arch. Biochem. Biophys, 82: 70–77.
  301. induced inhibition of cellular reactive oxygen species generation: novel therapeutic implications. J. Biosci., 28: 715–721.
  302. 129
  303. Lowry, O.H. Rosebrough N.J. Farr, A.L., Randall, R.J. 1951. Protein measurement with the Folin phenol reagent. J. Biol.
  304. Kalpana, C., Sudheer A.R., Rajasekharan K.N. and Menon V.P. 2007. Comparative effects of curcumin and its synthetic
  305. Balasubramanyam, M., Koteswari A.A., Kumar R.S., Monickaraj S.F., Maheswari J.U. and Mohan V. 2003. Curcumin
  306. Lowry, O.H. Rosebrough N.J. Farr, A.L., Randall, R.J. 1951. Protein measurement with the Folin phenol reagent. J. Biol.
  307. Kalpana, C., Sudheer A.R., Rajasekharan K.N. and Menon V.P. 2007. Comparative effects of curcumin and its synthetic
  308. induced inhibition of cellular reactive oxygen species generation: novel therapeutic implications. J. Biosci., 28: 715–721.
  309. Nurs., 7: 241-255
  310. Ajay, Goel Ajaikumar, B.K. unnumakkara and Bhaarat B. Aggarwal. 2008. Curcumin as (curcumin): Fromm kitchen to
  311. clinic.
  312. Nurs., 7: 241-255
  313. Kalpana, C., Sudheer A.R., Rajasekharan K.N. and Menon V.P. 2007. Comparative effects of curcumin and its synthetic
  314. Alderton, W.K., Cooper C.E. and Knowles R.G. 2001. Nitric oxide synthases: structure, function and inhibition. Biochem. J.,
  315. Kalpana, C. and Menon V.P. 2004. Inhibition of nicotine-induced toxicity by curcumin and curcumin analog: a comparative
  316. 537-544.
  317. Biochem., 95: 351-358.
  318. by cytochrome P450 2B6. Drug Metab. Dispos., 33: 1760-1764.
  319. Balasubramanyam, M., Koteswari A.A., Kumar R.S., Monickaraj S.F., Maheswari J.U. and Mohan V. 2003. Curcumin
  320. induced inhibition of cellular reactive oxygen species generation: novel therapeutic implications. J. Biosci., 28: 715–721.
  321. induced inhibition of cellular reactive oxygen species generation: novel therapeutic implications. J. Biosci., 28: 715–721.
  322. induced inhibition of cellular reactive oxygen species generation: novel therapeutic implications. J. Biosci., 28: 715–721.
  323. induced inhibition of cellular reactive oxygen species generation: novel therapeutic implications. J. Biosci., 28: 715–721.
  324. Ajay, Goel Ajaikumar, B.K. unnumakkara and Bhaarat B. Aggarwal. 2008. Curcumin as (curcumin): Fromm kitchen to
  325. clinic.
  326. Convenient Assay for Superoxide Dismutase. Eur. J. Biochem., 47: 469-474
  327. Choi, J., Hoffman L.A., Rodway G.W. and Sethi J.M. 2006. Markers of lung disease in exhaled breath: nitric oxide. Biol. Res.
  328. Alderton, W.K., Cooper C.E. and Knowles R.G. 2001. Nitric oxide synthases: structure, function and inhibition. Biochem. J.,
  329. Kalpana, C. and Menon V.P. 2004. Inhibition of nicotine-induced toxicity by curcumin and curcumin analog: a comparative
  330. 537-544.
  331. Biochem., 95: 351-358.
  332. Lowry, O.H. Rosebrough N.J. Farr, A.L., Randall, R.J. 1951. Protein measurement with the Folin phenol reagent. J. Biol.
  333. by cytochrome P450 2B6. Drug Metab. Dispos., 33: 1760-1764.
  334. Balasubramanyam, M., Koteswari A.A., Kumar R.S., Monickaraj S.F., Maheswari J.U. and Mohan V. 2003. Curcumin
  335. 129
  336. analogue on tissue lipid peroxidation and antioxidant status during nicotine-induced toxicity. Singapore Med. J., 48(2): 124-
  337. pathway in adenocarcinoma cells. J. Biol. Chem., 265: 14143-14149
  338. Chem., 193: 265-275
  339. Lepovire, M., Chenais B. and Yapo Al. 1990. Alterations of ribonucleotide reductase activity following induction of nitritegenerating
  340. Marklund, S. and Marklund G. 1974. Involvement of the Superoxide Anion Radical in the Autoxidation of Pyrogallol and a
  341. Alderton, W.K., Cooper C.E. and Knowles R.G. 2001. Nitric oxide synthases: structure, function and inhibition. Biochem. J.,
  342. Kalpana, C. and Menon V.P. 2004. Inhibition of nicotine-induced toxicity by curcumin and curcumin analog: a comparative
  343. 537-544.
  344. Biochem., 95: 351-358.
  345. Alderton, W.K., Cooper C.E. and Knowles R.G. 2001. Nitric oxide synthases: structure, function and inhibition. Biochem. J.,
  346. Kalpana, C. and Menon V.P. 2004. Inhibition of nicotine-induced toxicity by curcumin and curcumin analog: a comparative
  347. 537-544.
  348. Biochem., 95: 351-358.
  349. Ajay, Goel Ajaikumar, B.K. unnumakkara and Bhaarat B. Aggarwal. 2008. Curcumin as (curcumin): Fromm kitchen to
  350. clinic.
  351. Ajay, Goel Ajaikumar, B.K. unnumakkara and Bhaarat B. Aggarwal. 2008. Curcumin as (curcumin): Fromm kitchen to
  352. clinic.
  353. Lee, H.I., Mc Gregor R.A., Choi M.S., Seo K.I., Jung U.J., Yeo J., Kim M.J. and Lee M.K. 2013. Low doses of curcumin
  354. protect alcohol-induced liver damage by modulation of the alcohol metabolic pathway, CYP2E1 and AMPK. Life Sci., 13(2):
  355. Ohkawa, H.; Ohishi N. and Yagi, K. 1979. Assay for lipid peroxides in animal tissues by thiobarbituric acid reaction. Anal.
  356. Dicke, K.E., Skrlin S.M. and Murphy S.E. 2005. Nicotine and 4-(methylnitrosamino)-1-(3-pyridyl)-butanone metabolism
  357. Nurs., 7: 241-255
  358. Dicke, K.E., Skrlin S.M. and Murphy S.E. 2005. Nicotine and 4-(methylnitrosamino)-1-(3-pyridyl)-butanone metabolism
  359. induced inhibition of cellular reactive oxygen species generation: novel therapeutic implications. J. Biosci., 28: 715–721.
  360. Lee, H.I., Mc Gregor R.A., Choi M.S., Seo K.I., Jung U.J., Yeo J., Kim M.J. and Lee M.K. 2013. Low doses of curcumin
  361. 129
  362. Nurs., 7: 241-255
  363. induced inhibition of cellular reactive oxygen species generation: novel therapeutic implications. J. Biosci., 28: 715–721.
  364. Lepovire, M., Chenais B. and Yapo Al. 1990. Alterations of ribonucleotide reductase activity following induction of nitritegenerating
  365. Marklund, S. and Marklund G. 1974. Involvement of the Superoxide Anion Radical in the Autoxidation of Pyrogallol and a
  366. Lee, H.I., Mc Gregor R.A., Choi M.S., Seo K.I., Jung U.J., Yeo J., Kim M.J. and Lee M.K. 2013. Low doses of curcumin
  367. Nurs., 7: 241-255
  368. Biochem. Pharmacol., 75(4): 787-809.
  369. 357: 593-615.
  370. Convenient Assay for Superoxide Dismutase. Eur. J. Biochem., 47: 469-474
  371. Choi, J., Hoffman L.A., Rodway G.W. and Sethi J.M. 2006. Markers of lung disease in exhaled breath: nitric oxide. Biol. Res.
  372. analogue on tissue lipid peroxidation and antioxidant status during nicotine-induced toxicity. Singapore Med. J., 48(2): 124-
  373. pathway in adenocarcinoma cells. J. Biol. Chem., 265: 14143-14149
  374. Chem., 193: 265-275
  375. by cytochrome P450 2B6. Drug Metab. Dispos., 33: 1760-1764.
  376. Nurs., 7: 241-255
  377. Dicke, K.E., Skrlin S.M. and Murphy S.E. 2005. Nicotine and 4-(methylnitrosamino)-1-(3-pyridyl)-butanone metabolism
  378. 129
  379. Ogna, A. Noirez L. Lazor R. and Nicod L.P. 2012. Respiratory brochiolitis and respiratory brochiolitis-associated
  380. interstitial lung disease. Rev. Med. Suisse, 21(8): 2228-2232.
  381. Balasubramanyam, M., Koteswari A.A., Kumar R.S., Monickaraj S.F., Maheswari J.U. and Mohan V. 2003. Curcumin
  382. induced inhibition of cellular reactive oxygen species generation: novel therapeutic implications. J. Biosci., 28: 715–721.
  383. Lowry, O.H. Rosebrough N.J. Farr, A.L., Randall, R.J. 1951. Protein measurement with the Folin phenol reagent. J. Biol.
  384. Nurs., 7: 241-255
  385. Kalpana, C., Sudheer A.R., Rajasekharan K.N. and Menon V.P. 2007. Comparative effects of curcumin and its synthetic
  386. Ellman, G.L. 1959. Tissue sulfhydryl groups. Arch. Biochem. Biophys, 82: 70–77.
  387. induced inhibition of cellular reactive oxygen species generation: novel therapeutic implications. J. Biosci., 28: 715–721.
  388. analogue on tissue lipid peroxidation and antioxidant status during nicotine-induced toxicity. Singapore Med. J., 48(2): 124-
  389. pathway in adenocarcinoma cells. J. Biol. Chem., 265: 14143-14149
  390. Chem., 193: 265-275
  391. Lee, H.I., Mc Gregor R.A., Choi M.S., Seo K.I., Jung U.J., Yeo J., Kim M.J. and Lee M.K. 2013. Low doses of curcumin
  392. analogue on tissue lipid peroxidation and antioxidant status during nicotine-induced toxicity. Singapore Med. J., 48(2): 124-
  393. pathway in adenocarcinoma cells. J. Biol. Chem., 265: 14143-14149
  394. Chem., 193: 265-275
  395. Ellman, G.L. 1959. Tissue sulfhydryl groups. Arch. Biochem. Biophys, 82: 70–77.
  396. Convenient Assay for Superoxide Dismutase. Eur. J. Biochem., 47: 469-474
  397. Choi, J., Hoffman L.A., Rodway G.W. and Sethi J.M. 2006. Markers of lung disease in exhaled breath: nitric oxide. Biol. Res.
  398. Convenient Assay for Superoxide Dismutase. Eur. J. Biochem., 47: 469-474
  399. Choi, J., Hoffman L.A., Rodway G.W. and Sethi J.M. 2006. Markers of lung disease in exhaled breath: nitric oxide. Biol. Res.
  400. analogue on tissue lipid peroxidation and antioxidant status during nicotine-induced toxicity. Singapore Med. J., 48(2): 124-
  401. pathway in adenocarcinoma cells. J. Biol. Chem., 265: 14143-14149
  402. Chem., 193: 265-275
  403. Kalpana, C., Sudheer A.R., Rajasekharan K.N. and Menon V.P. 2007. Comparative effects of curcumin and its synthetic
  404. by cytochrome P450 2B6. Drug Metab. Dispos., 33: 1760-1764.
  405. Balasubramanyam, M., Koteswari A.A., Kumar R.S., Monickaraj S.F., Maheswari J.U. and Mohan V. 2003. Curcumin
  406. Alderton, W.K., Cooper C.E. and Knowles R.G. 2001. Nitric oxide synthases: structure, function and inhibition. Biochem. J.,
  407. Kalpana, C. and Menon V.P. 2004. Inhibition of nicotine-induced toxicity by curcumin and curcumin analog: a comparative
  408. 537-544.
  409. Biochem., 95: 351-358.
  410. Lee, H.I., Mc Gregor R.A., Choi M.S., Seo K.I., Jung U.J., Yeo J., Kim M.J. and Lee M.K. 2013. Low doses of curcumin
  411. Nurs., 7: 241-255
  412. Nurs., 7: 241-255
  413. study. J. Med. Food, 7: 467-471
  414. Nurs., 7: 241-255
  415. Nurs., 7: 241-255
  416. study. J. Med. Food, 7: 467-471
  417. Ajay, Goel Ajaikumar, B.K. unnumakkara and Bhaarat B. Aggarwal. 2008. Curcumin as (curcumin): Fromm kitchen to
  418. clinic.
  419. Convenient Assay for Superoxide Dismutase. Eur. J. Biochem., 47: 469-474
  420. Alderton, W.K., Cooper C.E. and Knowles R.G. 2001. Nitric oxide synthases: structure, function and inhibition. Biochem. J.,
  421. Kalpana, C. and Menon V.P. 2004. Inhibition of nicotine-induced toxicity by curcumin and curcumin analog: a comparative
  422. 537-544.
  423. Biochem., 95: 351-358.
  424. analogue on tissue lipid peroxidation and antioxidant status during nicotine-induced toxicity. Singapore Med. J., 48(2): 124-
  425. pathway in adenocarcinoma cells. J. Biol. Chem., 265: 14143-14149
  426. Chem., 193: 265-275
  427. interstitial lung disease. Rev. Med. Suisse, 21(8): 2228-2232.
  428. Choi, J., Hoffman L.A., Rodway G.W. and Sethi J.M. 2006. Markers of lung disease in exhaled breath: nitric oxide. Biol. Res.
  429. Ajay, Goel Ajaikumar, B.K. unnumakkara and Bhaarat B. Aggarwal. 2008. Curcumin as (curcumin): Fromm kitchen to
  430. clinic.
  431. Alderton, W.K., Cooper C.E. and Knowles R.G. 2001. Nitric oxide synthases: structure, function and inhibition. Biochem. J.,
  432. Kalpana, C. and Menon V.P. 2004. Inhibition of nicotine-induced toxicity by curcumin and curcumin analog: a comparative
  433. 537-544.
  434. Biochem., 95: 351-358.
  435. Chem., 193: 265-275
  436. protect alcohol-induced liver damage by modulation of the alcohol metabolic pathway, CYP2E1 and AMPK. Life Sci., 13(2):
  437. Ohkawa, H.; Ohishi N. and Yagi, K. 1979. Assay for lipid peroxides in animal tissues by thiobarbituric acid reaction. Anal.
  438. Lowry, O.H. Rosebrough N.J. Farr, A.L., Randall, R.J. 1951. Protein measurement with the Folin phenol reagent. J. Biol.
  439. 129
  440. Ajay, Goel Ajaikumar, B.K. unnumakkara and Bhaarat B. Aggarwal. 2008. Curcumin as (curcumin): Fromm kitchen to
  441. clinic.
  442. protect alcohol-induced liver damage by modulation of the alcohol metabolic pathway, CYP2E1 and AMPK. Life Sci., 13(2):
  443. Ohkawa, H.; Ohishi N. and Yagi, K. 1979. Assay for lipid peroxides in animal tissues by thiobarbituric acid reaction. Anal.
  444. Choi, J., Hoffman L.A., Rodway G.W. and Sethi J.M. 2006. Markers of lung disease in exhaled breath: nitric oxide. Biol. Res.
  445. Nurs., 7: 241-255
  446. Ellman, G.L. 1959. Tissue sulfhydryl groups. Arch. Biochem. Biophys, 82: 70–77.
  447. Biochem. Pharmacol., 75(4): 787-809.
  448. 357: 593-615.
  449. Ogna, A. Noirez L. Lazor R. and Nicod L.P. 2012. Respiratory brochiolitis and respiratory brochiolitis-associated
  450. Nurs., 7: 241-255
  451. analogue on tissue lipid peroxidation and antioxidant status during nicotine-induced toxicity. Singapore Med. J., 48(2): 124-
  452. pathway in adenocarcinoma cells. J. Biol. Chem., 265: 14143-14149
  453. 537-544.
  454. Biochem., 95: 351-358.
  455. Lee, H.I., Mc Gregor R.A., Choi M.S., Seo K.I., Jung U.J., Yeo J., Kim M.J. and Lee M.K. 2013. Low doses of curcumin
  456. Dicke, K.E., Skrlin S.M. and Murphy S.E. 2005. Nicotine and 4-(methylnitrosamino)-1-(3-pyridyl)-butanone metabolism
  457. Alderton, W.K., Cooper C.E. and Knowles R.G. 2001. Nitric oxide synthases: structure, function and inhibition. Biochem. J.,
  458. Kalpana, C. and Menon V.P. 2004. Inhibition of nicotine-induced toxicity by curcumin and curcumin analog: a comparative
  459. 537-544.
  460. Biochem., 95: 351-358.
  461. Nurs., 7: 241-255
  462. Convenient Assay for Superoxide Dismutase. Eur. J. Biochem., 47: 469-474
  463. Lowry, O.H. Rosebrough N.J. Farr, A.L., Randall, R.J. 1951. Protein measurement with the Folin phenol reagent. J. Biol.
  464. 129
  465. Kalpana, C., Sudheer A.R., Rajasekharan K.N. and Menon V.P. 2007. Comparative effects of curcumin and its synthetic
  466. Biochem. Pharmacol., 75(4): 787-809.
  467. 357: 593-615.
  468. Ogna, A. Noirez L. Lazor R. and Nicod L.P. 2012. Respiratory brochiolitis and respiratory brochiolitis-associated
  469. interstitial lung disease. Rev. Med. Suisse, 21(8): 2228-2232.
  470. study. J. Med. Food, 7: 467-471
  471. Ogna, A. Noirez L. Lazor R. and Nicod L.P. 2012. Respiratory brochiolitis and respiratory brochiolitis-associated
  472. interstitial lung disease. Rev. Med. Suisse, 21(8): 2228-2232.
  473. Lowry, O.H. Rosebrough N.J. Farr, A.L., Randall, R.J. 1951. Protein measurement with the Folin phenol reagent. J. Biol.
  474. interstitial lung disease. Rev. Med. Suisse, 21(8): 2228-2232.
  475. Ogna, A. Noirez L. Lazor R. and Nicod L.P. 2012. Respiratory brochiolitis and respiratory brochiolitis-associated
  476. Dicke, K.E., Skrlin S.M. and Murphy S.E. 2005. Nicotine and 4-(methylnitrosamino)-1-(3-pyridyl)-butanone metabolism
  477. Biochem. Pharmacol., 75(4): 787-809.
  478. 357: 593-615.
  479. Alderton, W.K., Cooper C.E. and Knowles R.G. 2001. Nitric oxide synthases: structure, function and inhibition. Biochem. J.,
  480. Kalpana, C. and Menon V.P. 2004. Inhibition of nicotine-induced toxicity by curcumin and curcumin analog: a comparative
  481. Alderton, W.K., Cooper C.E. and Knowles R.G. 2001. Nitric oxide synthases: structure, function and inhibition. Biochem. J.,
  482. Kalpana, C. and Menon V.P. 2004. Inhibition of nicotine-induced toxicity by curcumin and curcumin analog: a comparative
  483. 537-544.
  484. Biochem., 95: 351-358.
  485. Dicke, K.E., Skrlin S.M. and Murphy S.E. 2005. Nicotine and 4-(methylnitrosamino)-1-(3-pyridyl)-butanone metabolism
  486. Nurs., 7: 241-255
  487. Convenient Assay for Superoxide Dismutase. Eur. J. Biochem., 47: 469-474
  488. Choi, J., Hoffman L.A., Rodway G.W. and Sethi J.M. 2006. Markers of lung disease in exhaled breath: nitric oxide. Biol. Res.
  489. induced inhibition of cellular reactive oxygen species generation: novel therapeutic implications. J. Biosci., 28: 715–721.
  490. Nurs., 7: 241-255
  491. Biochem. Pharmacol., 75(4): 787-809.
  492. 357: 593-615.
  493. Lepovire, M., Chenais B. and Yapo Al. 1990. Alterations of ribonucleotide reductase activity following induction of nitritegenerating
  494. Marklund, S. and Marklund G. 1974. Involvement of the Superoxide Anion Radical in the Autoxidation of Pyrogallol and a
  495. Dicke, K.E., Skrlin S.M. and Murphy S.E. 2005. Nicotine and 4-(methylnitrosamino)-1-(3-pyridyl)-butanone metabolism
  496. Kalpana, C., Sudheer A.R., Rajasekharan K.N. and Menon V.P. 2007. Comparative effects of curcumin and its synthetic
  497. study. J. Med. Food, 7: 467-471
  498. study. J. Med. Food, 7: 467-471
  499. Ajay, Goel Ajaikumar, B.K. unnumakkara and Bhaarat B. Aggarwal. 2008. Curcumin as (curcumin): Fromm kitchen to
  500. clinic.
  501. Ajay, Goel Ajaikumar, B.K. unnumakkara and Bhaarat B. Aggarwal. 2008. Curcumin as (curcumin): Fromm kitchen to
  502. clinic.
  503. Lepovire, M., Chenais B. and Yapo Al. 1990. Alterations of ribonucleotide reductase activity following induction of nitritegenerating
  504. Marklund, S. and Marklund G. 1974. Involvement of the Superoxide Anion Radical in the Autoxidation of Pyrogallol and a
  505. Kalpana, C., Sudheer A.R., Rajasekharan K.N. and Menon V.P. 2007. Comparative effects of curcumin and its synthetic
  506. Ellman, G.L. 1959. Tissue sulfhydryl groups. Arch. Biochem. Biophys, 82: 70–77.
  507. study. J. Med. Food, 7: 467-471
  508. Alderton, W.K., Cooper C.E. and Knowles R.G. 2001. Nitric oxide synthases: structure, function and inhibition. Biochem. J.,
  509. Kalpana, C. and Menon V.P. 2004. Inhibition of nicotine-induced toxicity by curcumin and curcumin analog: a comparative
  510. 537-544.
  511. Biochem., 95: 351-358.
  512. Convenient Assay for Superoxide Dismutase. Eur. J. Biochem., 47: 469-474
  513. Choi, J., Hoffman L.A., Rodway G.W. and Sethi J.M. 2006. Markers of lung disease in exhaled breath: nitric oxide. Biol. Res.
  514. induced inhibition of cellular reactive oxygen species generation: novel therapeutic implications. J. Biosci., 28: 715–721.
  515. study. J. Med. Food, 7: 467-471
  516. Kalpana, C., Sudheer A.R., Rajasekharan K.N. and Menon V.P. 2007. Comparative effects of curcumin and its synthetic
  517. induced inhibition of cellular reactive oxygen species generation: novel therapeutic implications. J. Biosci., 28: 715–721.
  518. Lee, H.I., Mc Gregor R.A., Choi M.S., Seo K.I., Jung U.J., Yeo J., Kim M.J. and Lee M.K. 2013. Low doses of curcumin
  519. Dicke, K.E., Skrlin S.M. and Murphy S.E. 2005. Nicotine and 4-(methylnitrosamino)-1-(3-pyridyl)-butanone metabolism
  520. induced inhibition of cellular reactive oxygen species generation: novel therapeutic implications. J. Biosci., 28: 715–721.
  521. induced inhibition of cellular reactive oxygen species generation: novel therapeutic implications. J. Biosci., 28: 715–721.
  522. study. J. Med. Food, 7: 467-471
  523. Dicke, K.E., Skrlin S.M. and Murphy S.E. 2005. Nicotine and 4-(methylnitrosamino)-1-(3-pyridyl)-butanone metabolism
  524. Lepovire, M., Chenais B. and Yapo Al. 1990. Alterations of ribonucleotide reductase activity following induction of nitritegenerating
  525. Marklund, S. and Marklund G. 1974. Involvement of the Superoxide Anion Radical in the Autoxidation of Pyrogallol and a
  526. by cytochrome P450 2B6. Drug Metab. Dispos., 33: 1760-1764.
  527. Balasubramanyam, M., Koteswari A.A., Kumar R.S., Monickaraj S.F., Maheswari J.U. and Mohan V. 2003. Curcumin
  528. Ellman, G.L. 1959. Tissue sulfhydryl groups. Arch. Biochem. Biophys, 82: 70–77.
  529. by cytochrome P450 2B6. Drug Metab. Dispos., 33: 1760-1764.
  530. Balasubramanyam, M., Koteswari A.A., Kumar R.S., Monickaraj S.F., Maheswari J.U. and Mohan V. 2003. Curcumin
  531. Lowry, O.H. Rosebrough N.J. Farr, A.L., Randall, R.J. 1951. Protein measurement with the Folin phenol reagent. J. Biol.
  532. study. J. Med. Food, 7: 467-471
  533. Alderton, W.K., Cooper C.E. and Knowles R.G. 2001. Nitric oxide synthases: structure, function and inhibition. Biochem. J.,
  534. Kalpana, C. and Menon V.P. 2004. Inhibition of nicotine-induced toxicity by curcumin and curcumin analog: a comparative
  535. 537-544.
  536. Biochem., 95: 351-358.
  537. Ajay, Goel Ajaikumar, B.K. unnumakkara and Bhaarat B. Aggarwal. 2008. Curcumin as (curcumin): Fromm kitchen to
  538. clinic.
  539. Kalpana, C., Sudheer A.R., Rajasekharan K.N. and Menon V.P. 2007. Comparative effects of curcumin and its synthetic
  540. Lowry, O.H. Rosebrough N.J. Farr, A.L., Randall, R.J. 1951. Protein measurement with the Folin phenol reagent. J. Biol.
  541. Ajay, Goel Ajaikumar, B.K. unnumakkara and Bhaarat B. Aggarwal. 2008. Curcumin as (curcumin): Fromm kitchen to
  542. clinic.
  543. 129
  544. induced inhibition of cellular reactive oxygen species generation: novel therapeutic implications. J. Biosci., 28: 715–721.
  545. Dicke, K.E., Skrlin S.M. and Murphy S.E. 2005. Nicotine and 4-(methylnitrosamino)-1-(3-pyridyl)-butanone metabolism
  546. Dicke, K.E., Skrlin S.M. and Murphy S.E. 2005. Nicotine and 4-(methylnitrosamino)-1-(3-pyridyl)-butanone metabolism
  547. Kalpana, C., Sudheer A.R., Rajasekharan K.N. and Menon V.P. 2007. Comparative effects of curcumin and its synthetic
  548. analogue on tissue lipid peroxidation and antioxidant status during nicotine-induced toxicity. Singapore Med. J., 48(2): 124-
  549. pathway in adenocarcinoma cells. J. Biol. Chem., 265: 14143-14149
  550. Chem., 193: 265-275
  551. study. J. Med. Food, 7: 467-471
  552. Nurs., 7: 241-255
  553. by cytochrome P450 2B6. Drug Metab. Dispos., 33: 1760-1764.
  554. Balasubramanyam, M., Koteswari A.A., Kumar R.S., Monickaraj S.F., Maheswari J.U. and Mohan V. 2003. Curcumin
  555. study. J. Med. Food, 7: 467-471
  556. Convenient Assay for Superoxide Dismutase. Eur. J. Biochem., 47: 469-474
  557. Choi, J., Hoffman L.A., Rodway G.W. and Sethi J.M. 2006. Markers of lung disease in exhaled breath: nitric oxide. Biol. Res.
  558. Nurs., 7: 241-255
  559. Lee, H.I., Mc Gregor R.A., Choi M.S., Seo K.I., Jung U.J., Yeo J., Kim M.J. and Lee M.K. 2013. Low doses of curcumin
  560. Alderton, W.K., Cooper C.E. and Knowles R.G. 2001. Nitric oxide synthases: structure, function and inhibition. Biochem. J.,
  561. Kalpana, C. and Menon V.P. 2004. Inhibition of nicotine-induced toxicity by curcumin and curcumin analog: a comparative
  562. 537-544.
  563. Biochem., 95: 351-358.
  564. Alderton, W.K., Cooper C.E. and Knowles R.G. 2001. Nitric oxide synthases: structure, function and inhibition. Biochem. J.,
  565. Kalpana, C. and Menon V.P. 2004. Inhibition of nicotine-induced toxicity by curcumin and curcumin analog: a comparative
  566. 537-544.
  567. Biochem., 95: 351-358.
  568. Dicke, K.E., Skrlin S.M. and Murphy S.E. 2005. Nicotine and 4-(methylnitrosamino)-1-(3-pyridyl)-butanone metabolism
  569. Ajay, Goel Ajaikumar, B.K. unnumakkara and Bhaarat B. Aggarwal. 2008. Curcumin as (curcumin): Fromm kitchen to
  570. clinic.
  571. study. J. Med. Food, 7: 467-471
  572. induced inhibition of cellular reactive oxygen species generation: novel therapeutic implications. J. Biosci., 28: 715–721.
  573. 129
  574. Convenient Assay for Superoxide Dismutase. Eur. J. Biochem., 47: 469-474
  575. Choi, J., Hoffman L.A., Rodway G.W. and Sethi J.M. 2006. Markers of lung disease in exhaled breath: nitric oxide. Biol. Res.
  576. Ajay, Goel Ajaikumar, B.K. unnumakkara and Bhaarat B. Aggarwal. 2008. Curcumin as (curcumin): Fromm kitchen to
  577. clinic.
  578. analogue on tissue lipid peroxidation and antioxidant status during nicotine-induced toxicity. Singapore Med. J., 48(2): 124-
  579. pathway in adenocarcinoma cells. J. Biol. Chem., 265: 14143-14149
  580. Chem., 193: 265-275
  581. study. J. Med. Food, 7: 467-471
  582. Kalpana, C., Sudheer A.R., Rajasekharan K.N. and Menon V.P. 2007. Comparative effects of curcumin and its synthetic
  583. 129
  584. by cytochrome P450 2B6. Drug Metab. Dispos., 33: 1760-1764.
  585. Balasubramanyam, M., Koteswari A.A., Kumar R.S., Monickaraj S.F., Maheswari J.U. and Mohan V. 2003. Curcumin
  586. Dicke, K.E., Skrlin S.M. and Murphy S.E. 2005. Nicotine and 4-(methylnitrosamino)-1-(3-pyridyl)-butanone metabolism
  587. Ellman, G.L. 1959. Tissue sulfhydryl groups. Arch. Biochem. Biophys, 82: 70–77.
  588. Nurs., 7: 241-255
  589. 129
  590. Chem., 193: 265-275
  591. by cytochrome P450 2B6. Drug Metab. Dispos., 33: 1760-1764.
  592. Balasubramanyam, M., Koteswari A.A., Kumar R.S., Monickaraj S.F., Maheswari J.U. and Mohan V. 2003. Curcumin
  593. analogue on tissue lipid peroxidation and antioxidant status during nicotine-induced toxicity. Singapore Med. J., 48(2): 124-
  594. pathway in adenocarcinoma cells. J. Biol. Chem., 265: 14143-14149
  595. Ajay, Goel Ajaikumar, B.K. unnumakkara and Bhaarat B. Aggarwal. 2008. Curcumin as (curcumin): Fromm kitchen to
  596. clinic.
  597. Ellman, G.L. 1959. Tissue sulfhydryl groups. Arch. Biochem. Biophys, 82: 70–77.
  598. Biochem. Pharmacol., 75(4): 787-809.
  599. 357: 593-615.
  600. Ogna, A. Noirez L. Lazor R. and Nicod L.P. 2012. Respiratory brochiolitis and respiratory brochiolitis-associated
  601. Ellman, G.L. 1959. Tissue sulfhydryl groups. Arch. Biochem. Biophys, 82: 70–77.
  602. analogue on tissue lipid peroxidation and antioxidant status during nicotine-induced toxicity. Singapore Med. J., 48(2): 124-
  603. pathway in adenocarcinoma cells. J. Biol. Chem., 265: 14143-14149
  604. Chem., 193: 265-275
  605. Biochem. Pharmacol., 75(4): 787-809.
  606. 357: 593-615.
  607. Ogna, A. Noirez L. Lazor R. and Nicod L.P. 2012. Respiratory brochiolitis and respiratory brochiolitis-associated
  608. interstitial lung disease. Rev. Med. Suisse, 21(8): 2228-2232.
  609. Dicke, K.E., Skrlin S.M. and Murphy S.E. 2005. Nicotine and 4-(methylnitrosamino)-1-(3-pyridyl)-butanone metabolism
  610. Lowry, O.H. Rosebrough N.J. Farr, A.L., Randall, R.J. 1951. Protein measurement with the Folin phenol reagent. J. Biol.
  611. Nurs., 7: 241-255
  612. Nurs., 7: 241-255
  613. interstitial lung disease. Rev. Med. Suisse, 21(8): 2228-2232.
  614. Alderton, W.K., Cooper C.E. and Knowles R.G. 2001. Nitric oxide synthases: structure, function and inhibition. Biochem. J.,
  615. Kalpana, C. and Menon V.P. 2004. Inhibition of nicotine-induced toxicity by curcumin and curcumin analog: a comparative
  616. 537-544.
  617. Biochem., 95: 351-358.
  618. Dicke, K.E., Skrlin S.M. and Murphy S.E. 2005. Nicotine and 4-(methylnitrosamino)-1-(3-pyridyl)-butanone metabolism
  619. Lee, H.I., Mc Gregor R.A., Choi M.S., Seo K.I., Jung U.J., Yeo J., Kim M.J. and Lee M.K. 2013. Low doses of curcumin
  620. Ellman, G.L. 1959. Tissue sulfhydryl groups. Arch. Biochem. Biophys, 82: 70–77.
  621. Biochem. Pharmacol., 75(4): 787-809.
  622. 357: 593-615.
  623. Ogna, A. Noirez L. Lazor R. and Nicod L.P. 2012. Respiratory brochiolitis and respiratory brochiolitis-associated
  624. interstitial lung disease. Rev. Med. Suisse, 21(8): 2228-2232.
  625. Lowry, O.H. Rosebrough N.J. Farr, A.L., Randall, R.J. 1951. Protein measurement with the Folin phenol reagent. J. Biol.
  626. Nurs., 7: 241-255
  627. study. J. Med. Food, 7: 467-471
  628. Nurs., 7: 241-255
  629. 129
  630. Lee, H.I., Mc Gregor R.A., Choi M.S., Seo K.I., Jung U.J., Yeo J., Kim M.J. and Lee M.K. 2013. Low doses of curcumin
  631. Convenient Assay for Superoxide Dismutase. Eur. J. Biochem., 47: 469-474
  632. Choi, J., Hoffman L.A., Rodway G.W. and Sethi J.M. 2006. Markers of lung disease in exhaled breath: nitric oxide. Biol. Res.
  633. Kalpana, C., Sudheer A.R., Rajasekharan K.N. and Menon V.P. 2007. Comparative effects of curcumin and its synthetic
  634. Ellman, G.L. 1959. Tissue sulfhydryl groups. Arch. Biochem. Biophys, 82: 70–77.
  635. Nurs., 7: 241-255
  636. by cytochrome P450 2B6. Drug Metab. Dispos., 33: 1760-1764.
  637. Balasubramanyam, M., Koteswari A.A., Kumar R.S., Monickaraj S.F., Maheswari J.U. and Mohan V. 2003. Curcumin
  638. protect alcohol-induced liver damage by modulation of the alcohol metabolic pathway, CYP2E1 and AMPK. Life Sci., 13(2):
  639. Ohkawa, H.; Ohishi N. and Yagi, K. 1979. Assay for lipid peroxides in animal tissues by thiobarbituric acid reaction. Anal.
  640. 129
  641. Lepovire, M., Chenais B. and Yapo Al. 1990. Alterations of ribonucleotide reductase activity following induction of nitritegenerating
  642. Kalpana, C. and Menon V.P. 2004. Inhibition of nicotine-induced toxicity by curcumin and curcumin analog: a comparative
  643. 537-544.
  644. Biochem., 95: 351-358.
  645. Marklund, S. and Marklund G. 1974. Involvement of the Superoxide Anion Radical in the Autoxidation of Pyrogallol and a
  646. study. J. Med. Food, 7: 467-471
  647. by cytochrome P450 2B6. Drug Metab. Dispos., 33: 1760-1764.
  648. Balasubramanyam, M., Koteswari A.A., Kumar R.S., Monickaraj S.F., Maheswari J.U. and Mohan V. 2003. Curcumin
  649. Lepovire, M., Chenais B. and Yapo Al. 1990. Alterations of ribonucleotide reductase activity following induction of nitritegenerating
  650. Marklund, S. and Marklund G. 1974. Involvement of the Superoxide Anion Radical in the Autoxidation of Pyrogallol and a
  651. analogue on tissue lipid peroxidation and antioxidant status during nicotine-induced toxicity. Singapore Med. J., 48(2): 124-
  652. pathway in adenocarcinoma cells. J. Biol. Chem., 265: 14143-14149
  653. Chem., 193: 265-275
  654. Lowry, O.H. Rosebrough N.J. Farr, A.L., Randall, R.J. 1951. Protein measurement with the Folin phenol reagent. J. Biol.
  655. study. J. Med. Food, 7: 467-471
  656. Dicke, K.E., Skrlin S.M. and Murphy S.E. 2005. Nicotine and 4-(methylnitrosamino)-1-(3-pyridyl)-butanone metabolism
  657. Lepovire, M., Chenais B. and Yapo Al. 1990. Alterations of ribonucleotide reductase activity following induction of nitritegenerating
  658. Marklund, S. and Marklund G. 1974. Involvement of the Superoxide Anion Radical in the Autoxidation of Pyrogallol and a
  659. protect alcohol-induced liver damage by modulation of the alcohol metabolic pathway, CYP2E1 and AMPK. Life Sci., 13(2):
  660. Ohkawa, H.; Ohishi N. and Yagi, K. 1979. Assay for lipid peroxides in animal tissues by thiobarbituric acid reaction. Anal.
  661. Alderton, W.K., Cooper C.E. and Knowles R.G. 2001. Nitric oxide synthases: structure, function and inhibition. Biochem. J.,
  662. Balasubramanyam, M., Koteswari A.A., Kumar R.S., Monickaraj S.F., Maheswari J.U. and Mohan V. 2003. Curcumin
  663. Kalpana, C., Sudheer A.R., Rajasekharan K.N. and Menon V.P. 2007. Comparative effects of curcumin and its synthetic
  664. study. J. Med. Food, 7: 467-471
  665. Nurs., 7: 241-255
  666. 129
  667. Lowry, O.H. Rosebrough N.J. Farr, A.L., Randall, R.J. 1951. Protein measurement with the Folin phenol reagent. J. Biol.
  668. Nurs., 7: 241-255
  669. Nurs., 7: 241-255
  670. analogue on tissue lipid peroxidation and antioxidant status during nicotine-induced toxicity. Singapore Med. J., 48(2): 124-
  671. pathway in adenocarcinoma cells. J. Biol. Chem., 265: 14143-14149
  672. Chem., 193: 265-275
  673. Biochem. Pharmacol., 75(4): 787-809.
  674. 357: 593-615.
  675. Ogna, A. Noirez L. Lazor R. and Nicod L.P. 2012. Respiratory brochiolitis and respiratory brochiolitis-associated
  676. interstitial lung disease. Rev. Med. Suisse, 21(8): 2228-2232.
  677. Alderton, W.K., Cooper C.E. and Knowles R.G. 2001. Nitric oxide synthases: structure, function and inhibition. Biochem. J.,
  678. Kalpana, C. and Menon V.P. 2004. Inhibition of nicotine-induced toxicity by curcumin and curcumin analog: a comparative
  679. 537-544.
  680. Biochem., 95: 351-358.
  681. Nurs., 7: 241-255
  682. Lowry, O.H. Rosebrough N.J. Farr, A.L., Randall, R.J. 1951. Protein measurement with the Folin phenol reagent. J. Biol.
  683. study. J. Med. Food, 7: 467-471
  684. by cytochrome P450 2B6. Drug Metab. Dispos., 33: 1760-1764.
  685. Dicke, K.E., Skrlin S.M. and Murphy S.E. 2005. Nicotine and 4-(methylnitrosamino)-1-(3-pyridyl)-butanone metabolism
  686. Lowry, O.H. Rosebrough N.J. Farr, A.L., Randall, R.J. 1951. Protein measurement with the Folin phenol reagent. J. Biol.
  687. Ellman, G.L. 1959. Tissue sulfhydryl groups. Arch. Biochem. Biophys, 82: 70–77.
  688. Nurs., 7: 241-255
  689. Biochem. Pharmacol., 75(4): 787-809.
  690. 357: 593-615.
  691. Ogna, A. Noirez L. Lazor R. and Nicod L.P. 2012. Respiratory brochiolitis and respiratory brochiolitis-associated
  692. interstitial lung disease. Rev. Med. Suisse, 21(8): 2228-2232.
  693. Lee, H.I., Mc Gregor R.A., Choi M.S., Seo K.I., Jung U.J., Yeo J., Kim M.J. and Lee M.K. 2013. Low doses of curcumin
  694. Lee, H.I., Mc Gregor R.A., Choi M.S., Seo K.I., Jung U.J., Yeo J., Kim M.J. and Lee M.K. 2013. Low doses of curcumin
  695. Lepovire, M., Chenais B. and Yapo Al. 1990. Alterations of ribonucleotide reductase activity following induction of nitritegenerating
  696. Marklund, S. and Marklund G. 1974. Involvement of the Superoxide Anion Radical in the Autoxidation of Pyrogallol and a
  697. Ellman, G.L. 1959. Tissue sulfhydryl groups. Arch. Biochem. Biophys, 82: 70–77.
  698. Ellman, G.L. 1959. Tissue sulfhydryl groups. Arch. Biochem. Biophys, 82: 70–77.
  699. Nurs., 7: 241-255
  700. Lepovire, M., Chenais B. and Yapo Al. 1990. Alterations of ribonucleotide reductase activity following induction of nitritegenerating
  701. Marklund, S. and Marklund G. 1974. Involvement of the Superoxide Anion Radical in the Autoxidation of Pyrogallol and a
  702. Ellman, G.L. 1959. Tissue sulfhydryl groups. Arch. Biochem. Biophys, 82: 70–77.
  703. Dicke, K.E., Skrlin S.M. and Murphy S.E. 2005. Nicotine and 4-(methylnitrosamino)-1-(3-pyridyl)-butanone metabolism
  704. by cytochrome P450 2B6. Drug Metab. Dispos., 33: 1760-1764.
  705. Balasubramanyam, M., Koteswari A.A., Kumar R.S., Monickaraj S.F., Maheswari J.U. and Mohan V. 2003. Curcumin
  706. Lee, H.I., Mc Gregor R.A., Choi M.S., Seo K.I., Jung U.J., Yeo J., Kim M.J. and Lee M.K. 2013. Low doses of curcumin
  707. Lowry, O.H. Rosebrough N.J. Farr, A.L., Randall, R.J. 1951. Protein measurement with the Folin phenol reagent. J. Biol.
  708. Ellman, G.L. 1959. Tissue sulfhydryl groups. Arch. Biochem. Biophys, 82: 70–77.
  709. Lepovire, M., Chenais B. and Yapo Al. 1990. Alterations of ribonucleotide reductase activity following induction of nitritegenerating
  710. Marklund, S. and Marklund G. 1974. Involvement of the Superoxide Anion Radical in the Autoxidation of Pyrogallol and a
  711. protect alcohol-induced liver damage by modulation of the alcohol metabolic pathway, CYP2E1 and AMPK. Life Sci., 13(2):
  712. Ohkawa, H.; Ohishi N. and Yagi, K. 1979. Assay for lipid peroxides in animal tissues by thiobarbituric acid reaction. Anal.
  713. Convenient Assay for Superoxide Dismutase. Eur. J. Biochem., 47: 469-474
  714. Biochem. Pharmacol., 75(4): 787-809.
  715. 357: 593-615.
  716. Ogna, A. Noirez L. Lazor R. and Nicod L.P. 2012. Respiratory brochiolitis and respiratory brochiolitis-associated
  717. interstitial lung disease. Rev. Med. Suisse, 21(8): 2228-2232.
  718. Nurs., 7: 241-255
  719. Choi, J., Hoffman L.A., Rodway G.W. and Sethi J.M. 2006. Markers of lung disease in exhaled breath: nitric oxide. Biol. Res.
  720. 129
  721. Lee, H.I., Mc Gregor R.A., Choi M.S., Seo K.I., Jung U.J., Yeo J., Kim M.J. and Lee M.K. 2013. Low doses of curcumin
  722. 129
  723. Nurs., 7: 241-255
  724. by cytochrome P450 2B6. Drug Metab. Dispos., 33: 1760-1764.
  725. Balasubramanyam, M., Koteswari A.A., Kumar R.S., Monickaraj S.F., Maheswari J.U. and Mohan V. 2003. Curcumin
  726. Biochem. Pharmacol., 75(4): 787-809.
  727. 357: 593-615.
  728. Ogna, A. Noirez L. Lazor R. and Nicod L.P. 2012. Respiratory brochiolitis and respiratory brochiolitis-associated
  729. interstitial lung disease. Rev. Med. Suisse, 21(8): 2228-2232.
  730. Ajay, Goel Ajaikumar, B.K. unnumakkara and Bhaarat B. Aggarwal. 2008. Curcumin as (curcumin): Fromm kitchen to
  731. clinic.
  732. Nurs., 7: 241-255
  733. Kalpana, C., Sudheer A.R., Rajasekharan K.N. and Menon V.P. 2007. Comparative effects of curcumin and its synthetic
  734. 129
  735. Convenient Assay for Superoxide Dismutase. Eur. J. Biochem., 47: 469-474
  736. Choi, J., Hoffman L.A., Rodway G.W. and Sethi J.M. 2006. Markers of lung disease in exhaled breath: nitric oxide. Biol. Res.
  737. Kalpana, C., Sudheer A.R., Rajasekharan K.N. and Menon V.P. 2007. Comparative effects of curcumin and its synthetic
  738. study. J. Med. Food, 7: 467-471
  739. Nurs., 7: 241-255
  740. Alderton, W.K., Cooper C.E. and Knowles R.G. 2001. Nitric oxide synthases: structure, function and inhibition. Biochem. J.,
  741. Kalpana, C. and Menon V.P. 2004. Inhibition of nicotine-induced toxicity by curcumin and curcumin analog: a comparative
  742. 537-544.
  743. Biochem., 95: 351-358.
  744. Alderton, W.K., Cooper C.E. and Knowles R.G. 2001. Nitric oxide synthases: structure, function and inhibition. Biochem. J.,
  745. Kalpana, C. and Menon V.P. 2004. Inhibition of nicotine-induced toxicity by curcumin and curcumin analog: a comparative
  746. 537-544.
  747. Biochem., 95: 351-358.
  748. Ajay, Goel Ajaikumar, B.K. unnumakkara and Bhaarat B. Aggarwal. 2008. Curcumin as (curcumin): Fromm kitchen to
  749. clinic.
  750. Dicke, K.E., Skrlin S.M. and Murphy S.E. 2005. Nicotine and 4-(methylnitrosamino)-1-(3-pyridyl)-butanone metabolism
  751. Kalpana, C., Sudheer A.R., Rajasekharan K.N. and Menon V.P. 2007. Comparative effects of curcumin and its synthetic
  752. 129
  753. Choi, J., Hoffman L.A., Rodway G.W. and Sethi J.M. 2006. Markers of lung disease in exhaled breath: nitric oxide. Biol. Res.
  754. Biochem. Pharmacol., 75(4): 787-809.
  755. 357: 593-615.
  756. Ogna, A. Noirez L. Lazor R. and Nicod L.P. 2012. Respiratory brochiolitis and respiratory brochiolitis-associated
  757. interstitial lung disease. Rev. Med. Suisse, 21(8): 2228-2232.
  758. Nurs., 7: 241-255
  759. by cytochrome P450 2B6. Drug Metab. Dispos., 33: 1760-1764.
  760. Balasubramanyam, M., Koteswari A.A., Kumar R.S., Monickaraj S.F., Maheswari J.U. and Mohan V. 2003. Curcumin
  761. 129
  762. Ajay, Goel Ajaikumar, B.K. unnumakkara and Bhaarat B. Aggarwal. 2008. Curcumin as (curcumin): Fromm kitchen to
  763. clinic.
  764. Lee, H.I., Mc Gregor R.A., Choi M.S., Seo K.I., Jung U.J., Yeo J., Kim M.J. and Lee M.K. 2013. Low doses of curcumin
  765. Convenient Assay for Superoxide Dismutase. Eur. J. Biochem., 47: 469-474
  766. Lowry, O.H. Rosebrough N.J. Farr, A.L., Randall, R.J. 1951. Protein measurement with the Folin phenol reagent. J. Biol.
  767. Lee, H.I., Mc Gregor R.A., Choi M.S., Seo K.I., Jung U.J., Yeo J., Kim M.J. and Lee M.K. 2013. Low doses of curcumin
  768. Nurs., 7: 241-255
  769. Ajay, Goel Ajaikumar, B.K. unnumakkara and Bhaarat B. Aggarwal. 2008. Curcumin as (curcumin): Fromm kitchen to
  770. clinic.
  771. study. J. Med. Food, 7: 467-471
  772. Alderton, W.K., Cooper C.E. and Knowles R.G. 2001. Nitric oxide synthases: structure, function and inhibition. Biochem. J.,
  773. Kalpana, C. and Menon V.P. 2004. Inhibition of nicotine-induced toxicity by curcumin and curcumin analog: a comparative
  774. 537-544.
  775. Biochem., 95: 351-358.
  776. induced inhibition of cellular reactive oxygen species generation: novel therapeutic implications. J. Biosci., 28: 715–721.
  777. Convenient Assay for Superoxide Dismutase. Eur. J. Biochem., 47: 469-474
  778. Choi, J., Hoffman L.A., Rodway G.W. and Sethi J.M. 2006. Markers of lung disease in exhaled breath: nitric oxide. Biol. Res.
  779. 129
  780. Lepovire, M., Chenais B. and Yapo Al. 1990. Alterations of ribonucleotide reductase activity following induction of nitritegenerating
  781. Marklund, S. and Marklund G. 1974. Involvement of the Superoxide Anion Radical in the Autoxidation of Pyrogallol and a
  782. Alderton, W.K., Cooper C.E. and Knowles R.G. 2001. Nitric oxide synthases: structure, function and inhibition. Biochem. J.,
  783. Kalpana, C. and Menon V.P. 2004. Inhibition of nicotine-induced toxicity by curcumin and curcumin analog: a comparative
  784. 537-544.
  785. Biochem., 95: 351-358.
  786. Lepovire, M., Chenais B. and Yapo Al. 1990. Alterations of ribonucleotide reductase activity following induction of nitritegenerating
  787. Marklund, S. and Marklund G. 1974. Involvement of the Superoxide Anion Radical in the Autoxidation of Pyrogallol and a
  788. Lepovire, M., Chenais B. and Yapo Al. 1990. Alterations of ribonucleotide reductase activity following induction of nitritegenerating
  789. Marklund, S. and Marklund G. 1974. Involvement of the Superoxide Anion Radical in the Autoxidation of Pyrogallol and a
  790. protect alcohol-induced liver damage by modulation of the alcohol metabolic pathway, CYP2E1 and AMPK. Life Sci., 13(2):
  791. Ohkawa, H.; Ohishi N. and Yagi, K. 1979. Assay for lipid peroxides in animal tissues by thiobarbituric acid reaction. Anal.
  792. Biochem. Pharmacol., 75(4): 787-809.
  793. 357: 593-615.
  794. Ogna, A. Noirez L. Lazor R. and Nicod L.P. 2012. Respiratory brochiolitis and respiratory brochiolitis-associated
  795. interstitial lung disease. Rev. Med. Suisse, 21(8): 2228-2232.
  796. Kalpana, C., Sudheer A.R., Rajasekharan K.N. and Menon V.P. 2007. Comparative effects of curcumin and its synthetic
  797. Lepovire, M., Chenais B. and Yapo Al. 1990. Alterations of ribonucleotide reductase activity following induction of nitritegenerating
  798. Lepovire, M., Chenais B. and Yapo Al. 1990. Alterations of ribonucleotide reductase activity following induction of nitritegenerating
  799. Marklund, S. and Marklund G. 1974. Involvement of the Superoxide Anion Radical in the Autoxidation of Pyrogallol and a
  800. protect alcohol-induced liver damage by modulation of the alcohol metabolic pathway, CYP2E1 and AMPK. Life Sci., 13(2):
  801. Ohkawa, H.; Ohishi N. and Yagi, K. 1979. Assay for lipid peroxides in animal tissues by thiobarbituric acid reaction. Anal.

Article Post Production

    No data exists for the row/column.
Creative Commons License
Indian Streams Research Journal by Laxmi Book Publication is licensed under a Creative Commons Attribution 4.0 International License.
Based on a work at http://oldisrj.lbp.world/Default.aspx.
Permissions beyond the scope of this license may be available at http://oldisrj.lbp.world/Default.aspx
Copyright © 2014 Indian Streams Research Journal. All rights reserved
Looking for information? Browse our FAQs, tour our sitemap, or contact ISRJ
Read our Privacy Policy Statement and Plagairism Policy. Use of this site signifies your agreement to the Terms of Use