DOI Prefix : 10.9780 | Journal DOI : 10.9780/22307850
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Volume : IV, Issue : I, February - 2014

DIMETHOATE INDUCED OXIDATIVE STRESS IN HEART ALBINO RAT

R. Penchalamma, Ramesh Babu. Kand and Jacob Doss. P

DOI : 10.9780/22307850, By : Laxmi Book Publication

Abstract :

Now days, peoples exposure to chemical compounds such as organphosphorous insecticide is continuously on the rise more and more. These compounds have induced an excessive production of free radicals which are responsible for several cell alterations in the organism. Recent investigations have proved the crucial role of nutritional antioxidants to prevent the damage caused by toxic compounds.Dimethoate (DM) is an organ phosphorous insecticide and acaricide used to kill mites and aphids among other insects and is applied on citrus, cotton, fruit, olives, potatoes, tea, tobacco and vegetables. The aim of the present work was to study biochemical changes that might occur in the heart of albino rats as a result of DM intoxication. In the present investigation the animals were treated with 1/10th of LD50of DM via oral gavage (34.5mg/kg body weight. The first group animals were considered as control animals. Second group of animals were treated with Dimethoate via oral gavage (34.5mg/kg body weight which is 1/10th of LD50) for 10 days, third and fourth groups of animals were administered for 20 and 30 days with an interval of 48h respectively. Total proteins showed decrement in the DM treated groups while all the other parameters selected in the present investigation showed an increment. The present findings indicate that chronic exposure to DM has clear toxic effect on the heart of albino rats.

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Cite This Article :

R. Penchalamma, Ramesh Babu. Kand and Jacob Doss. P(2014). DIMETHOATE INDUCED OXIDATIVE STRESS IN HEART ALBINO RAT. Indian Streams Research Journal, Vol. IV, Issue. I, DOI : 10.9780/22307850, http://isrj.org/UploadedData/4211.pdf

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  111. Beyer WE.Fridovich I.(1987). Assaying for SOD activity some large consequences of minor changes in conditions. 161 :
  112. Devi Srilakshmi Kala S, Umakanthi V, Jayasudha M, Malleswari M, RavikanthSV and Jacob Doss P,(2013). Effect of
  113. Cadet J, Bellon S, Berger M,Bourdat AG, Douki T,DuarteV, (2002). Recent aspects of oxidative DNA damage: guanine
  114. 16:1.
  115. marker of oxidative stress. Nutr Metab Cardiovasc Dis 15:316-28.
  116. Hagar HH, Fahmy AH, (2002). A biochemical, histochemical and ultrastructural evaluation of the effect of Dimethoate
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  118. Devi Srilakshmi Kala S, Umakanthi V, Jayasudha M, Malleswari M, RavikanthSV and Jacob Doss P,(2013). Effect of
  119. Halliwell B, Guteride JMC, Cross CE, (1992). Free radicals, antioxidants and human disease: where we now? J Lab Clin
  120. Hagar HH, Fahmy AH, (2002). A biochemical, histochemical and ultrastructural evaluation of the effect of Dimethoate
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  124. poising.J Toxicol Clin toxicol 33(3):257-60.
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  126. Heudorf U, ButteW, Schulz C, Angerer J, (2006). Reference values for metabolites of pyrethroid and organophosphorus
  127. Manna, S, BhattacharyyaD, MandalTKand Das S, (2005). Reported dose toxicity of Deltamethrin in rats. Indian journal of
  128. pharmacology, 37(3): 160-164.
  129. and brain of rats following subchronic exposure, Toxicology, 215: 2005b, p. 173-181.
  130. Beyer WE.Fridovich I.(1987). Assaying for SOD activity some large consequences of minor changes in conditions. 161 :
  131. Devi Srilakshmi Kala S, Umakanthi V, Jayasudha M, Malleswari M, RavikanthSV and Jacob Doss P,(2013). Effect of
  132. Toxicologic Pathology 59:237-243.
  133. Goetz ME, Luch A, (2008).Reactive species: a cell damaging rout assisting to chemical carcinogens. Cancer Lett 266: 73-
  134. 83.
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  138. Beyer WE.Fridovich I.(1987). Assaying for SOD activity some large consequences of minor changes in conditions. 161 :
  139. Devi Srilakshmi Kala S, Umakanthi V, Jayasudha M, Malleswari M, RavikanthSV and Jacob Doss P,(2013). Effect of
  140. 83.
  141. Del Rio D, Stewart AJ, Pellegrini NA, (2005).review of recent studies on malonialdehyde as toxic molecule and biological
  142. Aebi H, (1984). Catalase in vitro. Methods enzymol 105:121-6.
  143. Banerjee BD, Seth V.Ahmad RS.(2001). Pesticide – induced oxidative stress: perspective and trands. Rev environ health
  144. Heudorf U, ButteW, Schulz C, Angerer J, (2006). Reference values for metabolites of pyrethroid and organophosphorus
  145. Sharma Y, BashirS,Irshad M, DattaguptaS,Dogra, TD, (2005b.). Dimethoate- induced effects on antioxidant status of liver
  146. Toxicologic Pathology 59:237-243.
  147. Goetz ME, Luch A, (2008).Reactive species: a cell damaging rout assisting to chemical carcinogens. Cancer Lett 266: 73-
  148. Halliwell B, Guteride JMC, Cross CE, (1992). Free radicals, antioxidants and human disease: where we now? J Lab Clin
  149. De-Bleecker J, van-Den-Neucker K, Colradyn F, (1993).Intermediate syndromeinOrganophospharus poising: a prospective
  150. Banerjee BD, Seth V.Ahmad RS.(2001). Pesticide – induced oxidative stress: perspective and trands. Rev environ health
  151. Heudorf U, ButteW, Schulz C, Angerer J, (2006). Reference values for metabolites of pyrethroid and organophosphorus
  152. Del Rio D, Stewart AJ, Pellegrini NA, (2005).review of recent studies on malonialdehyde as toxic molecule and biological
  153. Sharma Y, BashirS,Irshad M, DattaguptaS,Dogra, TD, (2005b.). Dimethoate- induced effects on antioxidant status of liver
  154. study. Crit Care Med 21(11): 1706-11.
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  156. Cadet J, Bellon S, Berger M,Bourdat AG, Douki T,DuarteV, (2002). Recent aspects of oxidative DNA damage: guanine
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  160. Devi Srilakshmi Kala S, Umakanthi V, Jayasudha M, Malleswari M, RavikanthSV and Jacob Doss P,(2013). Effect of
  161. Beyer WE.Fridovich I.(1987). Assaying for SOD activity some large consequences of minor changes in conditions. 161 :
  162. Devi Srilakshmi Kala S, Umakanthi V, Jayasudha M, Malleswari M, RavikanthSV and Jacob Doss P,(2013). Effect of
  163. Devi Srilakshmi Kala S, Umakanthi V, Jayasudha M, Malleswari M, RavikanthSV and Jacob Doss P,(2013). Effect of
  164. Manna, S, BhattacharyyaD, MandalTKand Das S, (2005). Reported dose toxicity of Deltamethrin in rats. Indian journal of
  165. pharmacology, 37(3): 160-164.
  166. and brain of rats following subchronic exposure, Toxicology, 215: 2005b, p. 173-181.
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  168. pharmacology, 37(3): 160-164.
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  170. intoxication on rat pancreass. Toxicol Lett 133:161-70.
  171. poising.J Toxicol Clin toxicol 33(3):257-60.
  172. lesions, measurement and substrate specificity of DNA repair glycosylases. Biol Chem 383:93
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  174. Heudorf U, ButteW, Schulz C, Angerer J, (2006). Reference values for metabolites of pyrethroid and organophosphorus
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  176. marker of oxidative stress. Nutr Metab Cardiovasc Dis 15:316-28.
  177. Toxicologic Pathology 59:237-243.
  178. Goetz ME, Luch A, (2008).Reactive species: a cell damaging rout assisting to chemical carcinogens. Cancer Lett 266: 73-
  179. Manna, S, BhattacharyyaD, MandalTKand Das S, (2005). Reported dose toxicity of Deltamethrin in rats. Indian journal of
  180. pharmacology, 37(3): 160-164.
  181. and brain of rats following subchronic exposure, Toxicology, 215: 2005b, p. 173-181.
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  183. 83.
  184. intoxication on rat pancreass. Toxicol Lett 133:161-70.
  185. Betrosian A, Balla M,Kafiri G,Kofinas G, Makri R,Kakouri A. (1995). Multiple systems organ failure from organophosphate
  186. Fridovich I, Beachamp,(1995). Superoxide radical and superoxide dismutases. Annu.Rev.Biochem, 64-97.
  187. 559-66
  188. insecticides in urine for human bio monitoring in environmental medicine. Int J Hyg Environ Health, 209: 293-9.
  189. Beyer WE.Fridovich I.(1987). Assaying for SOD activity some large consequences of minor changes in conditions. 161 :
  190. Devi Srilakshmi Kala S, Umakanthi V, Jayasudha M, Malleswari M, RavikanthSV and Jacob Doss P,(2013). Effect of
  191. Toxicologic Pathology 59:237-243.
  192. Goetz ME, Luch A, (2008).Reactive species: a cell damaging rout assisting to chemical carcinogens. Cancer Lett 266: 73-
  193. study. Crit Care Med 21(11): 1706-11.
  194. Beyer WE.Fridovich I.(1987). Assaying for SOD activity some large consequences of minor changes in conditions. 161 :
  195. Devi Srilakshmi Kala S, Umakanthi V, Jayasudha M, Malleswari M, RavikanthSV and Jacob Doss P,(2013). Effect of
  196. Banerjee BD, Seth V.Ahmad RS.(2001). Pesticide – induced oxidative stress: perspective and trands. Rev environ health
  197. Heudorf U, ButteW, Schulz C, Angerer J, (2006). Reference values for metabolites of pyrethroid and organophosphorus
  198. intoxication on rat pancreass. Toxicol Lett 133:161-70.
  199. Banerjee BD, Seth V.Ahmad RS.(2001). Pesticide – induced oxidative stress: perspective and trands. Rev environ health
  200. Heudorf U, ButteW, Schulz C, Angerer J, (2006). Reference values for metabolites of pyrethroid and organophosphorus
  201. Betrosian A, Balla M,Kafiri G,Kofinas G, Makri R,Kakouri A. (1995). Multiple systems organ failure from organophosphate
  202. Beyer WE.Fridovich I.(1987). Assaying for SOD activity some large consequences of minor changes in conditions. 161 :
  203. Devi Srilakshmi Kala S, Umakanthi V, Jayasudha M, Malleswari M, RavikanthSV and Jacob Doss P,(2013). Effect of
  204. 16:1.
  205. marker of oxidative stress. Nutr Metab Cardiovasc Dis 15:316-28.
  206. Betrosian A, Balla M,Kafiri G,Kofinas G, Makri R,Kakouri A. (1995). Multiple systems organ failure from organophosphate
  207. Fridovich I, Beachamp,(1995). Superoxide radical and superoxide dismutases. Annu.Rev.Biochem, 64-97.
  208. Toxicologic Pathology 59:237-243.
  209. Goetz ME, Luch A, (2008).Reactive species: a cell damaging rout assisting to chemical carcinogens. Cancer Lett 266: 73-
  210. Fridovich I, Beachamp,(1995). Superoxide radical and superoxide dismutases. Annu.Rev.Biochem, 64-97.
  211. Beyer WE.Fridovich I.(1987). Assaying for SOD activity some large consequences of minor changes in conditions. 161 :
  212. Devi Srilakshmi Kala S, Umakanthi V, Jayasudha M, Malleswari M, RavikanthSV and Jacob Doss P,(2013). Effect of
  213. Toxicologic Pathology 59:237-243.
  214. Goetz ME, Luch A, (2008).Reactive species: a cell damaging rout assisting to chemical carcinogens. Cancer Lett 266: 73-
  215. Dimethoateon different regions of thebrain inAlbino rat. (In Press)
  216. study. Crit Care Med 21(11): 1706-11.
  217. Banerjee BD, Seth V.Ahmad RS.(2001). Pesticide – induced oxidative stress: perspective and trands. Rev environ health
  218. Heudorf U, ButteW, Schulz C, Angerer J, (2006). Reference values for metabolites of pyrethroid and organophosphorus
  219. Del Rio D, Stewart AJ, Pellegrini NA, (2005).review of recent studies on malonialdehyde as toxic molecule and biological
  220. Sharma Y, BashirS,Irshad M, DattaguptaS,Dogra, TD, (2005b.). Dimethoate- induced effects on antioxidant status of liver
  221. 83.
  222. 559-66
  223. insecticides in urine for human bio monitoring in environmental medicine. Int J Hyg Environ Health, 209: 293-9.
  224. Del Rio D, Stewart AJ, Pellegrini NA, (2005).review of recent studies on malonialdehyde as toxic molecule and biological
  225. and brain of rats following subchronic exposure, Toxicology, 215: 2005b, p. 173-181.
  226. Sharma Y, BashirS,Irshad M, DattaguptaS,Dogra, TD, (2005b.). Dimethoate- induced effects on antioxidant status of liver
  227. 83.
  228. Beyer WE.Fridovich I.(1987). Assaying for SOD activity some large consequences of minor changes in conditions. 161 :
  229. Devi Srilakshmi Kala S, Umakanthi V, Jayasudha M, Malleswari M, RavikanthSV and Jacob Doss P,(2013). Effect of
  230. Cadet J, Bellon S, Berger M,Bourdat AG, Douki T,DuarteV, (2002). Recent aspects of oxidative DNA damage: guanine
  231. Toxicologic Pathology 59:237-243.
  232. Goetz ME, Luch A, (2008).Reactive species: a cell damaging rout assisting to chemical carcinogens. Cancer Lett 266: 73-
  233. Dimethoateon different regions of thebrain inAlbino rat. (In Press)
  234. 559-66
  235. insecticides in urine for human bio monitoring in environmental medicine. Int J Hyg Environ Health, 209: 293-9.
  236. 559-66
  237. insecticides in urine for human bio monitoring in environmental medicine. Int J Hyg Environ Health, 209: 293-9.
  238. Hagar HH, Fahmy AH, (2002). A biochemical, histochemical and ultrastructural evaluation of the effect of Dimethoate
  239. De-Bleecker J, van-Den-Neucker K, Colradyn F, (1993).Intermediate syndromeinOrganophospharus poising: a prospective
  240. De-Bleecker J, van-Den-Neucker K, Colradyn F, (1993).Intermediate syndromeinOrganophospharus poising: a prospective
  241. Manna, S, BhattacharyyaD, MandalTKand Das S, (2005). Reported dose toxicity of Deltamethrin in rats. Indian journal of
  242. pharmacology, 37(3): 160-164.
  243. 559-66
  244. Beyer WE.Fridovich I.(1987). Assaying for SOD activity some large consequences of minor changes in conditions. 161 :
  245. Devi Srilakshmi Kala S, Umakanthi V, Jayasudha M, Malleswari M, RavikanthSV and Jacob Doss P,(2013). Effect of
  246. poising.J Toxicol Clin toxicol 33(3):257-60.
  247. lesions, measurement and substrate specificity of DNA repair glycosylases. Biol Chem 383:93
  248. insecticides in urine for human bio monitoring in environmental medicine. Int J Hyg Environ Health, 209: 293-9.
  249. Betrosian A, Balla M,Kafiri G,Kofinas G, Makri R,Kakouri A. (1995). Multiple systems organ failure from organophosphate
  250. Fridovich I, Beachamp,(1995). Superoxide radical and superoxide dismutases. Annu.Rev.Biochem, 64-97.
  251. Dimethoateon different regions of thebrain inAlbino rat. (In Press)
  252. study. Crit Care Med 21(11): 1706-11.
  253. Betrosian A, Balla M,Kafiri G,Kofinas G, Makri R,Kakouri A. (1995). Multiple systems organ failure from organophosphate
  254. Fridovich I, Beachamp,(1995). Superoxide radical and superoxide dismutases. Annu.Rev.Biochem, 64-97.
  255. intoxication on rat pancreass. Toxicol Lett 133:161-70.
  256. Banerjee BD, Seth V.Ahmad RS.(2001). Pesticide – induced oxidative stress: perspective and trands. Rev environ health
  257. De-Bleecker J, van-Den-Neucker K, Colradyn F, (1993).Intermediate syndromeinOrganophospharus poising: a prospective
  258. Heudorf U, ButteW, Schulz C, Angerer J, (2006). Reference values for metabolites of pyrethroid and organophosphorus
  259. Beyer WE.Fridovich I.(1987). Assaying for SOD activity some large consequences of minor changes in conditions. 161 :
  260. 16:1.
  261. Devi Srilakshmi Kala S, Umakanthi V, Jayasudha M, Malleswari M, RavikanthSV and Jacob Doss P,(2013). Effect of
  262. 83.
  263. marker of oxidative stress. Nutr Metab Cardiovasc Dis 15:316-28.
  264. Halliwell B, Guteride JMC, Cross CE, (1992). Free radicals, antioxidants and human disease: where we now? J Lab Clin
  265. Banerjee BD, Seth V.Ahmad RS.(2001). Pesticide – induced oxidative stress: perspective and trands. Rev environ health
  266. Heudorf U, ButteW, Schulz C, Angerer J, (2006). Reference values for metabolites of pyrethroid and organophosphorus
  267. Halliwell B, Guteride JMC, Cross CE, (1992). Free radicals, antioxidants and human disease: where we now? J Lab Clin
  268. Sharma Y, BashirS,Irshad M, DattaguptaS,Dogra, TD, (2005b.). Dimethoate- induced effects on antioxidant status of liver
  269. Beyer WE.Fridovich I.(1987). Assaying for SOD activity some large consequences of minor changes in conditions. 161 :
  270. 16:1.
  271. Devi Srilakshmi Kala S, Umakanthi V, Jayasudha M, Malleswari M, RavikanthSV and Jacob Doss P,(2013). Effect of
  272. marker of oxidative stress. Nutr Metab Cardiovasc Dis 15:316-28.
  273. Hagar HH, Fahmy AH, (2002). A biochemical, histochemical and ultrastructural evaluation of the effect of Dimethoate
  274. poising.J Toxicol Clin toxicol 33(3):257-60.
  275. Beyer WE.Fridovich I.(1987). Assaying for SOD activity some large consequences of minor changes in conditions. 161 :
  276. lesions, measurement and substrate specificity of DNA repair glycosylases. Biol Chem 383:93
  277. FerahSayim, (2007) Dimethoate-induced biochemical and histopathological changes in the liver of rats. Experimental and
  278. study. Crit Care Med 21(11): 1706-11.
  279. Betrosian A, Balla M,Kafiri G,Kofinas G, Makri R,Kakouri A. (1995). Multiple systems organ failure from organophosphate
  280. Fridovich I, Beachamp,(1995). Superoxide radical and superoxide dismutases. Annu.Rev.Biochem, 64-97.
  281. Beyer WE.Fridovich I.(1987). Assaying for SOD activity some large consequences of minor changes in conditions. 161 :
  282. Devi Srilakshmi Kala S, Umakanthi V, Jayasudha M, Malleswari M, RavikanthSV and Jacob Doss P,(2013). Effect of
  283. Beyer WE.Fridovich I.(1987). Assaying for SOD activity some large consequences of minor changes in conditions. 161 :
  284. Devi Srilakshmi Kala S, Umakanthi V, Jayasudha M, Malleswari M, RavikanthSV and Jacob Doss P,(2013). Effect of
  285. Cadet J, Bellon S, Berger M,Bourdat AG, Douki T,DuarteV, (2002). Recent aspects of oxidative DNA damage: guanine
  286. Devi Srilakshmi Kala S, Umakanthi V, Jayasudha M, Malleswari M, RavikanthSV and Jacob Doss P,(2013). Effect of
  287. Halliwell B, Guteride JMC, Cross CE, (1992). Free radicals, antioxidants and human disease: where we now? J Lab Clin
  288. Cadet J, Bellon S, Berger M,Bourdat AG, Douki T,DuarteV, (2002). Recent aspects of oxidative DNA damage: guanine
  289. Del Rio D, Stewart AJ, Pellegrini NA, (2005).review of recent studies on malonialdehyde as toxic molecule and biological
  290. Sharma Y, BashirS,Irshad M, DattaguptaS,Dogra, TD, (2005b.). Dimethoate- induced effects on antioxidant status of liver
  291. Cadet J, Bellon S, Berger M,Bourdat AG, Douki T,DuarteV, (2002). Recent aspects of oxidative DNA damage: guanine
  292. 83.
  293. De-Bleecker J, van-Den-Neucker K, Colradyn F, (1993).Intermediate syndromeinOrganophospharus poising: a prospective
  294. Del Rio D, Stewart AJ, Pellegrini NA, (2005).review of recent studies on malonialdehyde as toxic molecule and biological
  295. Dimethoateon different regions of thebrain inAlbino rat. (In Press)
  296. Sharma Y, BashirS,Irshad M, DattaguptaS,Dogra, TD, (2005b.). Dimethoate- induced effects on antioxidant status of liver
  297. Beyer WE.Fridovich I.(1987). Assaying for SOD activity some large consequences of minor changes in conditions. 161 :
  298. 83.
  299. Del Rio D, Stewart AJ, Pellegrini NA, (2005).review of recent studies on malonialdehyde as toxic molecule and biological
  300. De-Bleecker J, van-Den-Neucker K, Colradyn F, (1993).Intermediate syndromeinOrganophospharus poising: a prospective
  301. Toxicologic Pathology 59:237-243.
  302. Goetz ME, Luch A, (2008).Reactive species: a cell damaging rout assisting to chemical carcinogens. Cancer Lett 266: 73-
  303. Toxicologic Pathology 59:237-243.
  304. 16:1.
  305. Toxicologic Pathology 59:237-243.
  306. marker of oxidative stress. Nutr Metab Cardiovasc Dis 15:316-28.
  307. Goetz ME, Luch A, (2008).Reactive species: a cell damaging rout assisting to chemical carcinogens. Cancer Lett 266: 73-
  308. 83.
  309. FerahSayim, (2007) Dimethoate-induced biochemical and histopathological changes in the liver of rats. Experimental and
  310. Beyer WE.Fridovich I.(1987). Assaying for SOD activity some large consequences of minor changes in conditions. 161 :
  311. poising.J Toxicol Clin toxicol 33(3):257-60.
  312. lesions, measurement and substrate specificity of DNA repair glycosylases. Biol Chem 383:93
  313. study. Crit Care Med 21(11): 1706-11.
  314. Med 119:598-620
  315. Devi Srilakshmi Kala S, Umakanthi V, Jayasudha M, Malleswari M, RavikanthSV and Jacob Doss P,(2013). Effect of
  316. Betrosian A, Balla M,Kafiri G,Kofinas G, Makri R,Kakouri A. (1995). Multiple systems organ failure from organophosphate
  317. Beyer WE.Fridovich I.(1987). Assaying for SOD activity some large consequences of minor changes in conditions. 161 :
  318. Fridovich I, Beachamp,(1995). Superoxide radical and superoxide dismutases. Annu.Rev.Biochem, 64-97.
  319. Manna, S, BhattacharyyaD, MandalTKand Das S, (2005). Reported dose toxicity of Deltamethrin in rats. Indian journal of
  320. pharmacology, 37(3): 160-164.
  321. Devi Srilakshmi Kala S, Umakanthi V, Jayasudha M, Malleswari M, RavikanthSV and Jacob Doss P,(2013). Effect of
  322. and brain of rats following subchronic exposure, Toxicology, 215: 2005b, p. 173-181.
  323. FerahSayim, (2007) Dimethoate-induced biochemical and histopathological changes in the liver of rats. Experimental and
  324. Med 119:598-620
  325. De-Bleecker J, van-Den-Neucker K, Colradyn F, (1993).Intermediate syndromeinOrganophospharus poising: a prospective
  326. Betrosian A, Balla M,Kafiri G,Kofinas G, Makri R,Kakouri A. (1995). Multiple systems organ failure from organophosphate
  327. Fridovich I, Beachamp,(1995). Superoxide radical and superoxide dismutases. Annu.Rev.Biochem, 64-97.
  328. 559-66
  329. FerahSayim, (2007) Dimethoate-induced biochemical and histopathological changes in the liver of rats. Experimental and
  330. insecticides in urine for human bio monitoring in environmental medicine. Int J Hyg Environ Health, 209: 293-9.
  331. Med 119:598-620
  332. study. Crit Care Med 21(11): 1706-11.
  333. Betrosian A, Balla M,Kafiri G,Kofinas G, Makri R,Kakouri A. (1995). Multiple systems organ failure from organophosphate
  334. Fridovich I, Beachamp,(1995). Superoxide radical and superoxide dismutases. Annu.Rev.Biochem, 64-97.
  335. Toxicologic Pathology 59:237-243.
  336. Goetz ME, Luch A, (2008).Reactive species: a cell damaging rout assisting to chemical carcinogens. Cancer Lett 266: 73-
  337. FerahSayim, (2007) Dimethoate-induced biochemical and histopathological changes in the liver of rats. Experimental and
  338. Med 119:598-620
  339. Toxicologic Pathology 59:237-243.
  340. 559-66
  341. Goetz ME, Luch A, (2008).Reactive species: a cell damaging rout assisting to chemical carcinogens. Cancer Lett 266: 73-
  342. insecticides in urine for human bio monitoring in environmental medicine. Int J Hyg Environ Health, 209: 293-9.
  343. 83.
  344. De-Bleecker J, van-Den-Neucker K, Colradyn F, (1993).Intermediate syndromeinOrganophospharus poising: a prospective
  345. Halliwell B, Guteride JMC, Cross CE, (1992). Free radicals, antioxidants and human disease: where we now? J Lab Clin
  346. intoxication on rat pancreass. Toxicol Lett 133:161-70.
  347. Banerjee BD, Seth V.Ahmad RS.(2001). Pesticide – induced oxidative stress: perspective and trands. Rev environ health
  348. Aebi H, (1984). Catalase in vitro. Methods enzymol 105:121-6.
  349. Heudorf U, ButteW, Schulz C, Angerer J, (2006). Reference values for metabolites of pyrethroid and organophosphorus
  350. 83.
  351. Del Rio D, Stewart AJ, Pellegrini NA, (2005).review of recent studies on malonialdehyde as toxic molecule and biological
  352. Aebi H, (1984). Catalase in vitro. Methods enzymol 105:121-6.
  353. Sharma Y, BashirS,Irshad M, DattaguptaS,Dogra, TD, (2005b.). Dimethoate- induced effects on antioxidant status of liver
  354. Goetz ME, Luch A, (2008).Reactive species: a cell damaging rout assisting to chemical carcinogens. Cancer Lett 266: 73-
  355. Del Rio D, Stewart AJ, Pellegrini NA, (2005).review of recent studies on malonialdehyde as toxic molecule and biological
  356. Sharma Y, BashirS,Irshad M, DattaguptaS,Dogra, TD, (2005b.). Dimethoate- induced effects on antioxidant status of liver
  357. Toxicologic Pathology 59:237-243.
  358. Goetz ME, Luch A, (2008).Reactive species: a cell damaging rout assisting to chemical carcinogens. Cancer Lett 266: 73-
  359. Banerjee BD, Seth V.Ahmad RS.(2001). Pesticide – induced oxidative stress: perspective and trands. Rev environ health
  360. Banerjee BD, Seth V.Ahmad RS.(2001). Pesticide – induced oxidative stress: perspective and trands. Rev environ health
  361. Devi Srilakshmi Kala S, Umakanthi V, Jayasudha M, Malleswari M, RavikanthSV and Jacob Doss P,(2013). Effect of
  362. poising.J Toxicol Clin toxicol 33(3):257-60.
  363. lesions, measurement and substrate specificity of DNA repair glycosylases. Biol Chem 383:93
  364. Hagar HH, Fahmy AH, (2002). A biochemical, histochemical and ultrastructural evaluation of the effect of Dimethoate
  365. De-Bleecker J, van-Den-Neucker K, Colradyn F, (1993).Intermediate syndromeinOrganophospharus poising: a prospective
  366. 559-66
  367. insecticides in urine for human bio monitoring in environmental medicine. Int J Hyg Environ Health, 209: 293-9.
  368. Heudorf U, ButteW, Schulz C, Angerer J, (2006). Reference values for metabolites of pyrethroid and organophosphorus
  369. Manna, S, BhattacharyyaD, MandalTKand Das S, (2005). Reported dose toxicity of Deltamethrin in rats. Indian journal of
  370. pharmacology, 37(3): 160-164.
  371. 559-66
  372. and brain of rats following subchronic exposure, Toxicology, 215: 2005b, p. 173-181.
  373. insecticides in urine for human bio monitoring in environmental medicine. Int J Hyg Environ Health, 209: 293-9.
  374. 83.
  375. Betrosian A, Balla M,Kafiri G,Kofinas G, Makri R,Kakouri A. (1995). Multiple systems organ failure from organophosphate
  376. Fridovich I, Beachamp,(1995). Superoxide radical and superoxide dismutases. Annu.Rev.Biochem, 64-97.
  377. Manna, S, BhattacharyyaD, MandalTKand Das S, (2005). Reported dose toxicity of Deltamethrin in rats. Indian journal of
  378. pharmacology, 37(3): 160-164.
  379. and brain of rats following subchronic exposure, Toxicology, 215: 2005b, p. 173-181.
  380. Beyer WE.Fridovich I.(1987). Assaying for SOD activity some large consequences of minor changes in conditions. 161 :
  381. Devi Srilakshmi Kala S, Umakanthi V, Jayasudha M, Malleswari M, RavikanthSV and Jacob Doss P,(2013). Effect of
  382. poising.J Toxicol Clin toxicol 33(3):257-60.
  383. 559-66
  384. lesions, measurement and substrate specificity of DNA repair glycosylases. Biol Chem 383:93
  385. Sharma Y, BashirS,Irshad M, DattaguptaS,Dogra, TD, (2005b.). Dimethoate- induced effects on antioxidant status of liver
  386. Dimethoateon different regions of thebrain inAlbino rat. (In Press)
  387. Aebi H, (1984). Catalase in vitro. Methods enzymol 105:121-6.
  388. insecticides in urine for human bio monitoring in environmental medicine. Int J Hyg Environ Health, 209: 293-9.
  389. Heudorf U, ButteW, Schulz C, Angerer J, (2006). Reference values for metabolites of pyrethroid and organophosphorus
  390. Banerjee BD, Seth V.Ahmad RS.(2001). Pesticide – induced oxidative stress: perspective and trands. Rev environ health
  391. Heudorf U, ButteW, Schulz C, Angerer J, (2006). Reference values for metabolites of pyrethroid and organophosphorus
  392. Del Rio D, Stewart AJ, Pellegrini NA, (2005).review of recent studies on malonialdehyde as toxic molecule and biological
  393. Sharma Y, BashirS,Irshad M, DattaguptaS,Dogra, TD, (2005b.). Dimethoate- induced effects on antioxidant status of liver
  394. Aebi H, (1984). Catalase in vitro. Methods enzymol 105:121-6.
  395. study. Crit Care Med 21(11): 1706-11.
  396. Manna, S, BhattacharyyaD, MandalTKand Das S, (2005). Reported dose toxicity of Deltamethrin in rats. Indian journal of
  397. pharmacology, 37(3): 160-164.
  398. and brain of rats following subchronic exposure, Toxicology, 215: 2005b, p. 173-181.
  399. poising.J Toxicol Clin toxicol 33(3):257-60.
  400. lesions, measurement and substrate specificity of DNA repair glycosylases. Biol Chem 383:93
  401. Manna, S, BhattacharyyaD, MandalTKand Das S, (2005). Reported dose toxicity of Deltamethrin in rats. Indian journal of
  402. pharmacology, 37(3): 160-164.
  403. and brain of rats following subchronic exposure, Toxicology, 215: 2005b, p. 173-181.
  404. Hagar HH, Fahmy AH, (2002). A biochemical, histochemical and ultrastructural evaluation of the effect of Dimethoate
  405. study. Crit Care Med 21(11): 1706-11.
  406. poising.J Toxicol Clin toxicol 33(3):257-60.
  407. Devi Srilakshmi Kala S, Umakanthi V, Jayasudha M, Malleswari M, RavikanthSV and Jacob Doss P,(2013). Effect of
  408. lesions, measurement and substrate specificity of DNA repair glycosylases. Biol Chem 383:93
  409. Del Rio D, Stewart AJ, Pellegrini NA, (2005).review of recent studies on malonialdehyde as toxic molecule and biological
  410. Sharma Y, BashirS,Irshad M, DattaguptaS,Dogra, TD, (2005b.). Dimethoate- induced effects on antioxidant status of liver
  411. Betrosian A, Balla M,Kafiri G,Kofinas G, Makri R,Kakouri A. (1995). Multiple systems organ failure from organophosphate
  412. Fridovich I, Beachamp,(1995). Superoxide radical and superoxide dismutases. Annu.Rev.Biochem, 64-97.
  413. Beyer WE.Fridovich I.(1987). Assaying for SOD activity some large consequences of minor changes in conditions. 161 :
  414. Del Rio D, Stewart AJ, Pellegrini NA, (2005).review of recent studies on malonialdehyde as toxic molecule and biological
  415. poising.J Toxicol Clin toxicol 33(3):257-60.
  416. lesions, measurement and substrate specificity of DNA repair glycosylases. Biol Chem 383:93
  417. FerahSayim, (2007) Dimethoate-induced biochemical and histopathological changes in the liver of rats. Experimental and
  418. Med 119:598-620
  419. 83.
  420. poising.J Toxicol Clin toxicol 33(3):257-60.
  421. lesions, measurement and substrate specificity of DNA repair glycosylases. Biol Chem 383:93
  422. Dimethoateon different regions of thebrain inAlbino rat. (In Press)
  423. FerahSayim, (2007) Dimethoate-induced biochemical and histopathological changes in the liver of rats. Experimental and
  424. Beyer WE.Fridovich I.(1987). Assaying for SOD activity some large consequences of minor changes in conditions. 161 :
  425. Devi Srilakshmi Kala S, Umakanthi V, Jayasudha M, Malleswari M, RavikanthSV and Jacob Doss P,(2013). Effect of
  426. Banerjee BD, Seth V.Ahmad RS.(2001). Pesticide – induced oxidative stress: perspective and trands. Rev environ health
  427. Med 119:598-620
  428. Heudorf U, ButteW, Schulz C, Angerer J, (2006). Reference values for metabolites of pyrethroid and organophosphorus
  429. Betrosian A, Balla M,Kafiri G,Kofinas G, Makri R,Kakouri A. (1995). Multiple systems organ failure from organophosphate
  430. Fridovich I, Beachamp,(1995). Superoxide radical and superoxide dismutases. Annu.Rev.Biochem, 64-97.
  431. 83.
  432. Halliwell B, Guteride JMC, Cross CE, (1992). Free radicals, antioxidants and human disease: where we now? J Lab Clin
  433. Beyer WE.Fridovich I.(1987). Assaying for SOD activity some large consequences of minor changes in conditions. 161 :
  434. Hagar HH, Fahmy AH, (2002). A biochemical, histochemical and ultrastructural evaluation of the effect of Dimethoate
  435. FerahSayim, (2007) Dimethoate-induced biochemical and histopathological changes in the liver of rats. Experimental and
  436. Med 119:598-620
  437. Hagar HH, Fahmy AH, (2002). A biochemical, histochemical and ultrastructural evaluation of the effect of Dimethoate
  438. intoxication on rat pancreass. Toxicol Lett 133:161-70.
  439. Halliwell B, Guteride JMC, Cross CE, (1992). Free radicals, antioxidants and human disease: where we now? J Lab Clin
  440. Hagar HH, Fahmy AH, (2002). A biochemical, histochemical and ultrastructural evaluation of the effect of Dimethoate
  441. Devi Srilakshmi Kala S, Umakanthi V, Jayasudha M, Malleswari M, RavikanthSV and Jacob Doss P,(2013). Effect of
  442. FerahSayim, (2007) Dimethoate-induced biochemical and histopathological changes in the liver of rats. Experimental and
  443. Med 119:598-620
  444. Halliwell B, Guteride JMC, Cross CE, (1992). Free radicals, antioxidants and human disease: where we now? J Lab Clin
  445. De-Bleecker J, van-Den-Neucker K, Colradyn F, (1993).Intermediate syndromeinOrganophospharus poising: a prospective
  446. Halliwell B, Guteride JMC, Cross CE, (1992). Free radicals, antioxidants and human disease: where we now? J Lab Clin
  447. Cadet J, Bellon S, Berger M,Bourdat AG, Douki T,DuarteV, (2002). Recent aspects of oxidative DNA damage: guanine
  448. Betrosian A, Balla M,Kafiri G,Kofinas G, Makri R,Kakouri A. (1995). Multiple systems organ failure from organophosphate
  449. Manna, S, BhattacharyyaD, MandalTKand Das S, (2005). Reported dose toxicity of Deltamethrin in rats. Indian journal of
  450. Fridovich I, Beachamp,(1995). Superoxide radical and superoxide dismutases. Annu.Rev.Biochem, 64-97.
  451. study. Crit Care Med 21(11): 1706-11.
  452. poising.J Toxicol Clin toxicol 33(3):257-60.
  453. lesions, measurement and substrate specificity of DNA repair glycosylases. Biol Chem 383:93
  454. Manna, S, BhattacharyyaD, MandalTKand Das S, (2005). Reported dose toxicity of Deltamethrin in rats. Indian journal of
  455. pharmacology, 37(3): 160-164.
  456. De-Bleecker J, van-Den-Neucker K, Colradyn F, (1993).Intermediate syndromeinOrganophospharus poising: a prospective
  457. pharmacology, 37(3): 160-164.
  458. Manna, S, BhattacharyyaD, MandalTKand Das S, (2005). Reported dose toxicity of Deltamethrin in rats. Indian journal of
  459. pharmacology, 37(3): 160-164.
  460. and brain of rats following subchronic exposure, Toxicology, 215: 2005b, p. 173-181.
  461. and brain of rats following subchronic exposure, Toxicology, 215: 2005b, p. 173-181.
  462. Cadet J, Bellon S, Berger M,Bourdat AG, Douki T,DuarteV, (2002). Recent aspects of oxidative DNA damage: guanine
  463. 83.
  464. De-Bleecker J, van-Den-Neucker K, Colradyn F, (1993).Intermediate syndromeinOrganophospharus poising: a prospective
  465. De-Bleecker J, van-Den-Neucker K, Colradyn F, (1993).Intermediate syndromeinOrganophospharus poising: a prospective
  466. poising.J Toxicol Clin toxicol 33(3):257-60.
  467. Banerjee BD, Seth V.Ahmad RS.(2001). Pesticide – induced oxidative stress: perspective and trands. Rev environ health
  468. Sharma Y, BashirS,Irshad M, DattaguptaS,Dogra, TD, (2005b.). Dimethoate- induced effects on antioxidant status of liver
  469. Aebi H, (1984). Catalase in vitro. Methods enzymol 105:121-6.
  470. Heudorf U, ButteW, Schulz C, Angerer J, (2006). Reference values for metabolites of pyrethroid and organophosphorus
  471. Toxicologic Pathology 59:237-243.
  472. poising.J Toxicol Clin toxicol 33(3):257-60.
  473. lesions, measurement and substrate specificity of DNA repair glycosylases. Biol Chem 383:93
  474. Halliwell B, Guteride JMC, Cross CE, (1992). Free radicals, antioxidants and human disease: where we now? J Lab Clin
  475. Halliwell B, Guteride JMC, Cross CE, (1992). Free radicals, antioxidants and human disease: where we now? J Lab Clin
  476. Cadet J, Bellon S, Berger M,Bourdat AG, Douki T,DuarteV, (2002). Recent aspects of oxidative DNA damage: guanine
  477. Beyer WE.Fridovich I.(1987). Assaying for SOD activity some large consequences of minor changes in conditions. 161 :
  478. Goetz ME, Luch A, (2008).Reactive species: a cell damaging rout assisting to chemical carcinogens. Cancer Lett 266: 73-
  479. 16:1.
  480. marker of oxidative stress. Nutr Metab Cardiovasc Dis 15:316-28.
  481. insecticides in urine for human bio monitoring in environmental medicine. Int J Hyg Environ Health, 209: 293-9.
  482. Devi Srilakshmi Kala S, Umakanthi V, Jayasudha M, Malleswari M, RavikanthSV and Jacob Doss P,(2013). Effect of
  483. Beyer WE.Fridovich I.(1987). Assaying for SOD activity some large consequences of minor changes in conditions. 161 :
  484. intoxication on rat pancreass. Toxicol Lett 133:161-70.
  485. Devi Srilakshmi Kala S, Umakanthi V, Jayasudha M, Malleswari M, RavikanthSV and Jacob Doss P,(2013). Effect of
  486. lesions, measurement and substrate specificity of DNA repair glycosylases. Biol Chem 383:93
  487. intoxication on rat pancreass. Toxicol Lett 133:161-70.
  488. 16:1.
  489. marker of oxidative stress. Nutr Metab Cardiovasc Dis 15:316-28.
  490. Dimethoateon different regions of thebrain inAlbino rat. (In Press)
  491. Hagar HH, Fahmy AH, (2002). A biochemical, histochemical and ultrastructural evaluation of the effect of Dimethoate
  492. Toxicologic Pathology 59:237-243.
  493. Goetz ME, Luch A, (2008).Reactive species: a cell damaging rout assisting to chemical carcinogens. Cancer Lett 266: 73-
  494. Toxicologic Pathology 59:237-243.
  495. De-Bleecker J, van-Den-Neucker K, Colradyn F, (1993).Intermediate syndromeinOrganophospharus poising: a prospective
  496. Goetz ME, Luch A, (2008).Reactive species: a cell damaging rout assisting to chemical carcinogens. Cancer Lett 266: 73-
  497. Beyer WE.Fridovich I.(1987). Assaying for SOD activity some large consequences of minor changes in conditions. 161 :
  498. and brain of rats following subchronic exposure, Toxicology, 215: 2005b, p. 173-181.
  499. Hagar HH, Fahmy AH, (2002). A biochemical, histochemical and ultrastructural evaluation of the effect of Dimethoate
  500. 16:1.
  501. Devi Srilakshmi Kala S, Umakanthi V, Jayasudha M, Malleswari M, RavikanthSV and Jacob Doss P,(2013). Effect of
  502. marker of oxidative stress. Nutr Metab Cardiovasc Dis 15:316-28.
  503. Dimethoateon different regions of thebrain inAlbino rat. (In Press)
  504. Beyer WE.Fridovich I.(1987). Assaying for SOD activity some large consequences of minor changes in conditions. 161 :
  505. Del Rio D, Stewart AJ, Pellegrini NA, (2005).review of recent studies on malonialdehyde as toxic molecule and biological
  506. Devi Srilakshmi Kala S, Umakanthi V, Jayasudha M, Malleswari M, RavikanthSV and Jacob Doss P,(2013). Effect of
  507. Hagar HH, Fahmy AH, (2002). A biochemical, histochemical and ultrastructural evaluation of the effect of Dimethoate
  508. Aebi H, (1984). Catalase in vitro. Methods enzymol 105:121-6.
  509. Banerjee BD, Seth V.Ahmad RS.(2001). Pesticide – induced oxidative stress: perspective and trands. Rev environ health
  510. 559-66
  511. Aebi H, (1984). Catalase in vitro. Methods enzymol 105:121-6.
  512. Cadet J, Bellon S, Berger M,Bourdat AG, Douki T,DuarteV, (2002). Recent aspects of oxidative DNA damage: guanine
  513. intoxication on rat pancreass. Toxicol Lett 133:161-70.
  514. Toxicologic Pathology 59:237-243.
  515. 559-66
  516. Goetz ME, Luch A, (2008).Reactive species: a cell damaging rout assisting to chemical carcinogens. Cancer Lett 266: 73-
  517. insecticides in urine for human bio monitoring in environmental medicine. Int J Hyg Environ Health, 209: 293-9.
  518. poising.J Toxicol Clin toxicol 33(3):257-60.
  519. lesions, measurement and substrate specificity of DNA repair glycosylases. Biol Chem 383:93
  520. Manna, S, BhattacharyyaD, MandalTKand Das S, (2005). Reported dose toxicity of Deltamethrin in rats. Indian journal of
  521. Aebi H, (1984). Catalase in vitro. Methods enzymol 105:121-6.
  522. pharmacology, 37(3): 160-164.
  523. 83.
  524. and brain of rats following subchronic exposure, Toxicology, 215: 2005b, p. 173-181.
  525. Heudorf U, ButteW, Schulz C, Angerer J, (2006). Reference values for metabolites of pyrethroid and organophosphorus
  526. Halliwell B, Guteride JMC, Cross CE, (1992). Free radicals, antioxidants and human disease: where we now? J Lab Clin
  527. De-Bleecker J, van-Den-Neucker K, Colradyn F, (1993).Intermediate syndromeinOrganophospharus poising: a prospective
  528. 83.
  529. Manna, S, BhattacharyyaD, MandalTKand Das S, (2005). Reported dose toxicity of Deltamethrin in rats. Indian journal of
  530. De-Bleecker J, van-Den-Neucker K, Colradyn F, (1993).Intermediate syndromeinOrganophospharus poising: a prospective
  531. pharmacology, 37(3): 160-164.
  532. and brain of rats following subchronic exposure, Toxicology, 215: 2005b, p. 173-181.
  533. 83.
  534. Del Rio D, Stewart AJ, Pellegrini NA, (2005).review of recent studies on malonialdehyde as toxic molecule and biological
  535. Sharma Y, BashirS,Irshad M, DattaguptaS,Dogra, TD, (2005b.). Dimethoate- induced effects on antioxidant status of liver
  536. Aebi H, (1984). Catalase in vitro. Methods enzymol 105:121-6.
  537. study. Crit Care Med 21(11): 1706-11.
  538. FerahSayim, (2007) Dimethoate-induced biochemical and histopathological changes in the liver of rats. Experimental and
  539. Beyer WE.Fridovich I.(1987). Assaying for SOD activity some large consequences of minor changes in conditions. 161 :
  540. Med 119:598-620
  541. Halliwell B, Guteride JMC, Cross CE, (1992). Free radicals, antioxidants and human disease: where we now? J Lab Clin
  542. study. Crit Care Med 21(11): 1706-11.
  543. Manna, S, BhattacharyyaD, MandalTKand Das S, (2005). Reported dose toxicity of Deltamethrin in rats. Indian journal of
  544. pharmacology, 37(3): 160-164.
  545. and brain of rats following subchronic exposure, Toxicology, 215: 2005b, p. 173-181.
  546. Devi Srilakshmi Kala S, Umakanthi V, Jayasudha M, Malleswari M, RavikanthSV and Jacob Doss P,(2013). Effect of
  547. Beyer WE.Fridovich I.(1987). Assaying for SOD activity some large consequences of minor changes in conditions. 161 :
  548. Manna, S, BhattacharyyaD, MandalTKand Das S, (2005). Reported dose toxicity of Deltamethrin in rats. Indian journal of
  549. pharmacology, 37(3): 160-164.
  550. and brain of rats following subchronic exposure, Toxicology, 215: 2005b, p. 173-181.
  551. Beyer WE.Fridovich I.(1987). Assaying for SOD activity some large consequences of minor changes in conditions. 161 :
  552. Devi Srilakshmi Kala S, Umakanthi V, Jayasudha M, Malleswari M, RavikanthSV and Jacob Doss P,(2013). Effect of
  553. Devi Srilakshmi Kala S, Umakanthi V, Jayasudha M, Malleswari M, RavikanthSV and Jacob Doss P,(2013). Effect of
  554. De-Bleecker J, van-Den-Neucker K, Colradyn F, (1993).Intermediate syndromeinOrganophospharus poising: a prospective
  555. Beyer WE.Fridovich I.(1987). Assaying for SOD activity some large consequences of minor changes in conditions. 161 :
  556. Devi Srilakshmi Kala S, Umakanthi V, Jayasudha M, Malleswari M, RavikanthSV and Jacob Doss P,(2013). Effect of
  557. 559-66
  558. Beyer WE.Fridovich I.(1987). Assaying for SOD activity some large consequences of minor changes in conditions. 161 :
  559. Devi Srilakshmi Kala S, Umakanthi V, Jayasudha M, Malleswari M, RavikanthSV and Jacob Doss P,(2013). Effect of
  560. insecticides in urine for human bio monitoring in environmental medicine. Int J Hyg Environ Health, 209: 293-9.
  561. FerahSayim, (2007) Dimethoate-induced biochemical and histopathological changes in the liver of rats. Experimental and
  562. Del Rio D, Stewart AJ, Pellegrini NA, (2005).review of recent studies on malonialdehyde as toxic molecule and biological
  563. Med 119:598-620
  564. Dimethoateon different regions of thebrain inAlbino rat. (In Press)
  565. De-Bleecker J, van-Den-Neucker K, Colradyn F, (1993).Intermediate syndromeinOrganophospharus poising: a prospective
  566. Sharma Y, BashirS,Irshad M, DattaguptaS,Dogra, TD, (2005b.). Dimethoate- induced effects on antioxidant status of liver
  567. Toxicologic Pathology 59:237-243.
  568. Toxicologic Pathology 59:237-243.
  569. Goetz ME, Luch A, (2008).Reactive species: a cell damaging rout assisting to chemical carcinogens. Cancer Lett 266: 73-
  570. Dimethoateon different regions of thebrain inAlbino rat. (In Press)
  571. intoxication on rat pancreass. Toxicol Lett 133:161-70.
  572. Beyer WE.Fridovich I.(1987). Assaying for SOD activity some large consequences of minor changes in conditions. 161 :
  573. intoxication on rat pancreass. Toxicol Lett 133:161-70.
  574. Cadet J, Bellon S, Berger M,Bourdat AG, Douki T,DuarteV, (2002). Recent aspects of oxidative DNA damage: guanine
  575. Devi Srilakshmi Kala S, Umakanthi V, Jayasudha M, Malleswari M, RavikanthSV and Jacob Doss P,(2013). Effect of
  576. Toxicologic Pathology 59:237-243.
  577. Dimethoateon different regions of thebrain inAlbino rat. (In Press)
  578. Goetz ME, Luch A, (2008).Reactive species: a cell damaging rout assisting to chemical carcinogens. Cancer Lett 266: 73-
  579. Toxicologic Pathology 59:237-243.
  580. Beyer WE.Fridovich I.(1987). Assaying for SOD activity some large consequences of minor changes in conditions. 161 :
  581. Goetz ME, Luch A, (2008).Reactive species: a cell damaging rout assisting to chemical carcinogens. Cancer Lett 266: 73-
  582. 16:1.
  583. marker of oxidative stress. Nutr Metab Cardiovasc Dis 15:316-28.
  584. Aebi H, (1984). Catalase in vitro. Methods enzymol 105:121-6.
  585. Aebi H, (1984). Catalase in vitro. Methods enzymol 105:121-6.
  586. Del Rio D, Stewart AJ, Pellegrini NA, (2005).review of recent studies on malonialdehyde as toxic molecule and biological
  587. Sharma Y, BashirS,Irshad M, DattaguptaS,Dogra, TD, (2005b.). Dimethoate- induced effects on antioxidant status of liver
  588. Beyer WE.Fridovich I.(1987). Assaying for SOD activity some large consequences of minor changes in conditions. 161 :
  589. Betrosian A, Balla M,Kafiri G,Kofinas G, Makri R,Kakouri A. (1995). Multiple systems organ failure from organophosphate
  590. Devi Srilakshmi Kala S, Umakanthi V, Jayasudha M, Malleswari M, RavikanthSV and Jacob Doss P,(2013). Effect of
  591. Betrosian A, Balla M,Kafiri G,Kofinas G, Makri R,Kakouri A. (1995). Multiple systems organ failure from organophosphate
  592. Fridovich I, Beachamp,(1995). Superoxide radical and superoxide dismutases. Annu.Rev.Biochem, 64-97.
  593. Toxicologic Pathology 59:237-243.
  594. Goetz ME, Luch A, (2008).Reactive species: a cell damaging rout assisting to chemical carcinogens. Cancer Lett 266: 73-
  595. Cadet J, Bellon S, Berger M,Bourdat AG, Douki T,DuarteV, (2002). Recent aspects of oxidative DNA damage: guanine
  596. Beyer WE.Fridovich I.(1987). Assaying for SOD activity some large consequences of minor changes in conditions. 161 :
  597. Devi Srilakshmi Kala S, Umakanthi V, Jayasudha M, Malleswari M, RavikanthSV and Jacob Doss P,(2013). Effect of
  598. Betrosian A, Balla M,Kafiri G,Kofinas G, Makri R,Kakouri A. (1995). Multiple systems organ failure from organophosphate
  599. Toxicologic Pathology 59:237-243.
  600. 83.
  601. Cadet J, Bellon S, Berger M,Bourdat AG, Douki T,DuarteV, (2002). Recent aspects of oxidative DNA damage: guanine
  602. 16:1.
  603. marker of oxidative stress. Nutr Metab Cardiovasc Dis 15:316-28.
  604. Fridovich I, Beachamp,(1995). Superoxide radical and superoxide dismutases. Annu.Rev.Biochem, 64-97.
  605. Banerjee BD, Seth V.Ahmad RS.(2001). Pesticide – induced oxidative stress: perspective and trands. Rev environ health
  606. Heudorf U, ButteW, Schulz C, Angerer J, (2006). Reference values for metabolites of pyrethroid and organophosphorus
  607. Banerjee BD, Seth V.Ahmad RS.(2001). Pesticide – induced oxidative stress: perspective and trands. Rev environ health
  608. Hagar HH, Fahmy AH, (2002). A biochemical, histochemical and ultrastructural evaluation of the effect of Dimethoate
  609. 16:1.
  610. marker of oxidative stress. Nutr Metab Cardiovasc Dis 15:316-28.
  611. Heudorf U, ButteW, Schulz C, Angerer J, (2006). Reference values for metabolites of pyrethroid and organophosphorus
  612. poising.J Toxicol Clin toxicol 33(3):257-60.
  613. Fridovich I, Beachamp,(1995). Superoxide radical and superoxide dismutases. Annu.Rev.Biochem, 64-97.
  614. Beyer WE.Fridovich I.(1987). Assaying for SOD activity some large consequences of minor changes in conditions. 161 :
  615. Devi Srilakshmi Kala S, Umakanthi V, Jayasudha M, Malleswari M, RavikanthSV and Jacob Doss P,(2013). Effect of
  616. Cadet J, Bellon S, Berger M,Bourdat AG, Douki T,DuarteV, (2002). Recent aspects of oxidative DNA damage: guanine
  617. lesions, measurement and substrate specificity of DNA repair glycosylases. Biol Chem 383:93
  618. study. Crit Care Med 21(11): 1706-11.
  619. 559-66
  620. Aebi H, (1984). Catalase in vitro. Methods enzymol 105:121-6.
  621. insecticides in urine for human bio monitoring in environmental medicine. Int J Hyg Environ Health, 209: 293-9.
  622. Goetz ME, Luch A, (2008).Reactive species: a cell damaging rout assisting to chemical carcinogens. Cancer Lett 266: 73-
  623. Devi Srilakshmi Kala S, Umakanthi V, Jayasudha M, Malleswari M, RavikanthSV and Jacob Doss P,(2013). Effect of
  624. 559-66
  625. Hagar HH, Fahmy AH, (2002). A biochemical, histochemical and ultrastructural evaluation of the effect of Dimethoate
  626. insecticides in urine for human bio monitoring in environmental medicine. Int J Hyg Environ Health, 209: 293-9.
  627. Toxicologic Pathology 59:237-243.
  628. Beyer WE.Fridovich I.(1987). Assaying for SOD activity some large consequences of minor changes in conditions. 161 :
  629. Goetz ME, Luch A, (2008).Reactive species: a cell damaging rout assisting to chemical carcinogens. Cancer Lett 266: 73-
  630. Devi Srilakshmi Kala S, Umakanthi V, Jayasudha M, Malleswari M, RavikanthSV and Jacob Doss P,(2013). Effect of
  631. Toxicologic Pathology 59:237-243.
  632. intoxication on rat pancreass. Toxicol Lett 133:161-70.
  633. Goetz ME, Luch A, (2008).Reactive species: a cell damaging rout assisting to chemical carcinogens. Cancer Lett 266: 73-
  634. Goetz ME, Luch A, (2008).Reactive species: a cell damaging rout assisting to chemical carcinogens. Cancer Lett 266: 73-
  635. 559-66
  636. Beyer WE.Fridovich I.(1987). Assaying for SOD activity some large consequences of minor changes in conditions. 161 :
  637. insecticides in urine for human bio monitoring in environmental medicine. Int J Hyg Environ Health, 209: 293-9.
  638. Devi Srilakshmi Kala S, Umakanthi V, Jayasudha M, Malleswari M, RavikanthSV and Jacob Doss P,(2013). Effect of
  639. De-Bleecker J, van-Den-Neucker K, Colradyn F, (1993).Intermediate syndromeinOrganophospharus poising: a prospective
  640. Dimethoateon different regions of thebrain inAlbino rat. (In Press)
  641. study. Crit Care Med 21(11): 1706-11.
  642. Beyer WE.Fridovich I.(1987). Assaying for SOD activity some large consequences of minor changes in conditions. 161 :
  643. Devi Srilakshmi Kala S, Umakanthi V, Jayasudha M, Malleswari M, RavikanthSV and Jacob Doss P,(2013). Effect of
  644. Del Rio D, Stewart AJ, Pellegrini NA, (2005).review of recent studies on malonialdehyde as toxic molecule and biological
  645. Sharma Y, BashirS,Irshad M, DattaguptaS,Dogra, TD, (2005b.). Dimethoate- induced effects on antioxidant status of liver
  646. poising.J Toxicol Clin toxicol 33(3):257-60.
  647. Beyer WE.Fridovich I.(1987). Assaying for SOD activity some large consequences of minor changes in conditions. 161 :
  648. lesions, measurement and substrate specificity of DNA repair glycosylases. Biol Chem 383:93
  649. 559-66
  650. Devi Srilakshmi Kala S, Umakanthi V, Jayasudha M, Malleswari M, RavikanthSV and Jacob Doss P,(2013). Effect of
  651. Halliwell B, Guteride JMC, Cross CE, (1992). Free radicals, antioxidants and human disease: where we now? J Lab Clin
  652. Betrosian A, Balla M,Kafiri G,Kofinas G, Makri R,Kakouri A. (1995). Multiple systems organ failure from organophosphate
  653. Dimethoateon different regions of thebrain inAlbino rat. (In Press)
  654. insecticides in urine for human bio monitoring in environmental medicine. Int J Hyg Environ Health, 209: 293-9.
  655. Cadet J, Bellon S, Berger M,Bourdat AG, Douki T,DuarteV, (2002). Recent aspects of oxidative DNA damage: guanine
  656. study. Crit Care Med 21(11): 1706-11.
  657. Betrosian A, Balla M,Kafiri G,Kofinas G, Makri R,Kakouri A. (1995). Multiple systems organ failure from organophosphate
  658. Toxicologic Pathology 59:237-243.
  659. Fridovich I, Beachamp,(1995). Superoxide radical and superoxide dismutases. Annu.Rev.Biochem, 64-97.
  660. Fridovich I, Beachamp,(1995). Superoxide radical and superoxide dismutases. Annu.Rev.Biochem, 64-97.
  661. FerahSayim, (2007) Dimethoate-induced biochemical and histopathological changes in the liver of rats. Experimental and
  662. Goetz ME, Luch A, (2008).Reactive species: a cell damaging rout assisting to chemical carcinogens. Cancer Lett 266: 73-
  663. Med 119:598-620
  664. 16:1.
  665. Banerjee BD, Seth V.Ahmad RS.(2001). Pesticide – induced oxidative stress: perspective and trands. Rev environ health
  666. Heudorf U, ButteW, Schulz C, Angerer J, (2006). Reference values for metabolites of pyrethroid and organophosphorus
  667. marker of oxidative stress. Nutr Metab Cardiovasc Dis 15:316-28.
  668. Beyer WE.Fridovich I.(1987). Assaying for SOD activity some large consequences of minor changes in conditions. 161 :
  669. Aebi H, (1984). Catalase in vitro. Methods enzymol 105:121-6.
  670. Devi Srilakshmi Kala S, Umakanthi V, Jayasudha M, Malleswari M, RavikanthSV and Jacob Doss P,(2013). Effect of
  671. Beyer WE.Fridovich I.(1987). Assaying for SOD activity some large consequences of minor changes in conditions. 161 :
  672. poising.J Toxicol Clin toxicol 33(3):257-60.
  673. Devi Srilakshmi Kala S, Umakanthi V, Jayasudha M, Malleswari M, RavikanthSV and Jacob Doss P,(2013). Effect of
  674. lesions, measurement and substrate specificity of DNA repair glycosylases. Biol Chem 383:93
  675. FerahSayim, (2007) Dimethoate-induced biochemical and histopathological changes in the liver of rats. Experimental and
  676. Del Rio D, Stewart AJ, Pellegrini NA, (2005).review of recent studies on malonialdehyde as toxic molecule and biological
  677. Med 119:598-620
  678. Sharma Y, BashirS,Irshad M, DattaguptaS,Dogra, TD, (2005b.). Dimethoate- induced effects on antioxidant status of liver
  679. 83.
  680. Betrosian A, Balla M,Kafiri G,Kofinas G, Makri R,Kakouri A. (1995). Multiple systems organ failure from organophosphate
  681. Fridovich I, Beachamp,(1995). Superoxide radical and superoxide dismutases. Annu.Rev.Biochem, 64-97.
  682. FerahSayim, (2007) Dimethoate-induced biochemical and histopathological changes in the liver of rats. Experimental and
  683. Med 119:598-620
  684. Halliwell B, Guteride JMC, Cross CE, (1992). Free radicals, antioxidants and human disease: where we now? J Lab Clin
  685. Halliwell B, Guteride JMC, Cross CE, (1992). Free radicals, antioxidants and human disease: where we now? J Lab Clin
  686. De-Bleecker J, van-Den-Neucker K, Colradyn F, (1993).Intermediate syndromeinOrganophospharus poising: a prospective
  687. Beyer WE.Fridovich I.(1987). Assaying for SOD activity some large consequences of minor changes in conditions. 161 :
  688. Devi Srilakshmi Kala S, Umakanthi V, Jayasudha M, Malleswari M, RavikanthSV and Jacob Doss P,(2013). Effect of
  689. 16:1.
  690. marker of oxidative stress. Nutr Metab Cardiovasc Dis 15:316-28.
  691. study. Crit Care Med 21(11): 1706-11.
  692. 16:1.
  693. marker of oxidative stress. Nutr Metab Cardiovasc Dis 15:316-28.
  694. Toxicologic Pathology 59:237-243.
  695. Goetz ME, Luch A, (2008).Reactive species: a cell damaging rout assisting to chemical carcinogens. Cancer Lett 266: 73-
  696. Dimethoateon different regions of thebrain inAlbino rat. (In Press)
  697. study. Crit Care Med 21(11): 1706-11.
  698. Toxicologic Pathology 59:237-243.
  699. Goetz ME, Luch A, (2008).Reactive species: a cell damaging rout assisting to chemical carcinogens. Cancer Lett 266: 73-
  700. Dimethoateon different regions of thebrain inAlbino rat. (In Press)
  701. Cadet J, Bellon S, Berger M,Bourdat AG, Douki T,DuarteV, (2002). Recent aspects of oxidative DNA damage: guanine
  702. Beyer WE.Fridovich I.(1987). Assaying for SOD activity some large consequences of minor changes in conditions. 161 :
  703. Devi Srilakshmi Kala S, Umakanthi V, Jayasudha M, Malleswari M, RavikanthSV and Jacob Doss P,(2013). Effect of
  704. Beyer WE.Fridovich I.(1987). Assaying for SOD activity some large consequences of minor changes in conditions. 161 :
  705. study. Crit Care Med 21(11): 1706-11.
  706. Beyer WE.Fridovich I.(1987). Assaying for SOD activity some large consequences of minor changes in conditions. 161 :
  707. Devi Srilakshmi Kala S, Umakanthi V, Jayasudha M, Malleswari M, RavikanthSV and Jacob Doss P,(2013). Effect of
  708. Beyer WE.Fridovich I.(1987). Assaying for SOD activity some large consequences of minor changes in conditions. 161 :
  709. Devi Srilakshmi Kala S, Umakanthi V, Jayasudha M, Malleswari M, RavikanthSV and Jacob Doss P,(2013). Effect of
  710. Del Rio D, Stewart AJ, Pellegrini NA, (2005).review of recent studies on malonialdehyde as toxic molecule and biological
  711. Sharma Y, BashirS,Irshad M, DattaguptaS,Dogra, TD, (2005b.). Dimethoate- induced effects on antioxidant status of liver
  712. intoxication on rat pancreass. Toxicol Lett 133:161-70.
  713. Aebi H, (1984). Catalase in vitro. Methods enzymol 105:121-6.
  714. 16:1.
  715. marker of oxidative stress. Nutr Metab Cardiovasc Dis 15:316-28.
  716. 16:1.
  717. marker of oxidative stress. Nutr Metab Cardiovasc Dis 15:316-28.
  718. Devi Srilakshmi Kala S, Umakanthi V, Jayasudha M, Malleswari M, RavikanthSV and Jacob Doss P,(2013). Effect of
  719. Halliwell B, Guteride JMC, Cross CE, (1992). Free radicals, antioxidants and human disease: where we now? J Lab Clin
  720. intoxication on rat pancreass. Toxicol Lett 133:161-70.
  721. Halliwell B, Guteride JMC, Cross CE, (1992). Free radicals, antioxidants and human disease: where we now? J Lab Clin
  722. 16:1.
  723. Del Rio D, Stewart AJ, Pellegrini NA, (2005).review of recent studies on malonialdehyde as toxic molecule and biological
  724. marker of oxidative stress. Nutr Metab Cardiovasc Dis 15:316-28.
  725. Dimethoateon different regions of thebrain inAlbino rat. (In Press)
  726. Sharma Y, BashirS,Irshad M, DattaguptaS,Dogra, TD, (2005b.). Dimethoate- induced effects on antioxidant status of liver
  727. Banerjee BD, Seth V.Ahmad RS.(2001). Pesticide – induced oxidative stress: perspective and trands. Rev environ health
  728. FerahSayim, (2007) Dimethoate-induced biochemical and histopathological changes in the liver of rats. Experimental and
  729. Heudorf U, ButteW, Schulz C, Angerer J, (2006). Reference values for metabolites of pyrethroid and organophosphorus
  730. Med 119:598-620
  731. 559-66
  732. Toxicologic Pathology 59:237-243.
  733. insecticides in urine for human bio monitoring in environmental medicine. Int J Hyg Environ Health, 209: 293-9.
  734. Goetz ME, Luch A, (2008).Reactive species: a cell damaging rout assisting to chemical carcinogens. Cancer Lett 266: 73-
  735. Hagar HH, Fahmy AH, (2002). A biochemical, histochemical and ultrastructural evaluation of the effect of Dimethoate
  736. Hagar HH, Fahmy AH, (2002). A biochemical, histochemical and ultrastructural evaluation of the effect of Dimethoate
  737. FerahSayim, (2007) Dimethoate-induced biochemical and histopathological changes in the liver of rats. Experimental and
  738. Cadet J, Bellon S, Berger M,Bourdat AG, Douki T,DuarteV, (2002). Recent aspects of oxidative DNA damage: guanine
  739. Med 119:598-620
  740. De-Bleecker J, van-Den-Neucker K, Colradyn F, (1993).Intermediate syndromeinOrganophospharus poising: a prospective
  741. 559-66
  742. De-Bleecker J, van-Den-Neucker K, Colradyn F, (1993).Intermediate syndromeinOrganophospharus poising: a prospective
  743. insecticides in urine for human bio monitoring in environmental medicine. Int J Hyg Environ Health, 209: 293-9.
  744. Betrosian A, Balla M,Kafiri G,Kofinas G, Makri R,Kakouri A. (1995). Multiple systems organ failure from organophosphate
  745. Fridovich I, Beachamp,(1995). Superoxide radical and superoxide dismutases. Annu.Rev.Biochem, 64-97.
  746. 559-66
  747. Del Rio D, Stewart AJ, Pellegrini NA, (2005).review of recent studies on malonialdehyde as toxic molecule and biological
  748. insecticides in urine for human bio monitoring in environmental medicine. Int J Hyg Environ Health, 209: 293-9.
  749. 83.
  750. Betrosian A, Balla M,Kafiri G,Kofinas G, Makri R,Kakouri A. (1995). Multiple systems organ failure from organophosphate
  751. Fridovich I, Beachamp,(1995). Superoxide radical and superoxide dismutases. Annu.Rev.Biochem, 64-97.
  752. Aebi H, (1984). Catalase in vitro. Methods enzymol 105:121-6.
  753. Betrosian A, Balla M,Kafiri G,Kofinas G, Makri R,Kakouri A. (1995). Multiple systems organ failure from organophosphate
  754. Fridovich I, Beachamp,(1995). Superoxide radical and superoxide dismutases. Annu.Rev.Biochem, 64-97.
  755. Cadet J, Bellon S, Berger M,Bourdat AG, Douki T,DuarteV, (2002). Recent aspects of oxidative DNA damage: guanine
  756. Dimethoateon different regions of thebrain inAlbino rat. (In Press)
  757. FerahSayim, (2007) Dimethoate-induced biochemical and histopathological changes in the liver of rats. Experimental and
  758. Med 119:598-620
  759. FerahSayim, (2007) Dimethoate-induced biochemical and histopathological changes in the liver of rats. Experimental and
  760. Med 119:598-620
  761. De-Bleecker J, van-Den-Neucker K, Colradyn F, (1993).Intermediate syndromeinOrganophospharus poising: a prospective
  762. Sharma Y, BashirS,Irshad M, DattaguptaS,Dogra, TD, (2005b.). Dimethoate- induced effects on antioxidant status of liver
  763. FerahSayim, (2007) Dimethoate-induced biochemical and histopathological changes in the liver of rats. Experimental and
  764. De-Bleecker J, van-Den-Neucker K, Colradyn F, (1993).Intermediate syndromeinOrganophospharus poising: a prospective
  765. Med 119:598-620
  766. Fridovich I, Beachamp,(1995). Superoxide radical and superoxide dismutases. Annu.Rev.Biochem, 64-97.
  767. Del Rio D, Stewart AJ, Pellegrini NA, (2005).review of recent studies on malonialdehyde as toxic molecule and biological
  768. 83.
  769. Sharma Y, BashirS,Irshad M, DattaguptaS,Dogra, TD, (2005b.). Dimethoate- induced effects on antioxidant status of liver
  770. Aebi H, (1984). Catalase in vitro. Methods enzymol 105:121-6.
  771. FerahSayim, (2007) Dimethoate-induced biochemical and histopathological changes in the liver of rats. Experimental and
  772. poising.J Toxicol Clin toxicol 33(3):257-60.
  773. Manna, S, BhattacharyyaD, MandalTKand Das S, (2005). Reported dose toxicity of Deltamethrin in rats. Indian journal of
  774. pharmacology, 37(3): 160-164.
  775. lesions, measurement and substrate specificity of DNA repair glycosylases. Biol Chem 383:93
  776. and brain of rats following subchronic exposure, Toxicology, 215: 2005b, p. 173-181.
  777. FerahSayim, (2007) Dimethoate-induced biochemical and histopathological changes in the liver of rats. Experimental and
  778. 16:1.
  779. Med 119:598-620
  780. marker of oxidative stress. Nutr Metab Cardiovasc Dis 15:316-28.
  781. Cadet J, Bellon S, Berger M,Bourdat AG, Douki T,DuarteV, (2002). Recent aspects of oxidative DNA damage: guanine
  782. Med 119:598-620
  783. Hagar HH, Fahmy AH, (2002). A biochemical, histochemical and ultrastructural evaluation of the effect of Dimethoate
  784. Dimethoateon different regions of thebrain inAlbino rat. (In Press)
  785. Toxicologic Pathology 59:237-243.
  786. Goetz ME, Luch A, (2008).Reactive species: a cell damaging rout assisting to chemical carcinogens. Cancer Lett 266: 73-
  787. Betrosian A, Balla M,Kafiri G,Kofinas G, Makri R,Kakouri A. (1995). Multiple systems organ failure from organophosphate
  788. Fridovich I, Beachamp,(1995). Superoxide radical and superoxide dismutases. Annu.Rev.Biochem, 64-97.
  789. Toxicologic Pathology 59:237-243.
  790. Goetz ME, Luch A, (2008).Reactive species: a cell damaging rout assisting to chemical carcinogens. Cancer Lett 266: 73-
  791. Beyer WE.Fridovich I.(1987). Assaying for SOD activity some large consequences of minor changes in conditions. 161 :
  792. Devi Srilakshmi Kala S, Umakanthi V, Jayasudha M, Malleswari M, RavikanthSV and Jacob Doss P,(2013). Effect of
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