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Volume : I, Issue : VI, July - 2011 Serum Interleukin-18 levels at a base line could serve as a better differentiating factor for carcinoma prostate and benign prostate hyperplasia –A study in north Indian population S Dwivedi , S Singh , V Gupta , A Goel , S M Natu , S Khattri DOI : 10.9780/22307850, Published By : Laxmi Book Publication Abstract : Aim: To explore the role of serum interleukin -18 (IL-18) levels and its
significance in prostate carcinoma patients.
Method: 90 subjects were enrolled during June 2010 to May 2011 after
Institutional ethical approval, 44 biopsy proven prostate cancer patients and age
matched independent 46 benign prostate hyperplasia (BPH) patients as controls
with in age group of 40-80 years. The Serum PSA level, interleukin-18 levels were
measured by enzyme linked immunosorbent assay (ELISA) and significance of
difference between various group was compared by using ANOVA analysis.
Results
The mean IL-18 of carcinoma prostate group was found to be significantly
(p<0.01) higher than BPH group. It also showed its increase value in patient with
its advanced stages. Keywords : Article : Cite This Article : S Dwivedi , S Singh , V Gupta , A Goel , S M Natu , S Khattri, (2011). Serum Interleukin-18 levels at a base line could serve as a better differentiating factor for carcinoma prostate and benign prostate hyperplasia –A study in north Indian population. Indian Streams Research Journal, Vol. I, Issue. VI, DOI : 10.9780/22307850, http://oldisrj.lbp.world/UploadedData/334.pdf References : - Chia CS, Ban K, Ithnin H, Singh H, Krishnan R, Mokhtar S, Malihan N, Seow HF: Expression of interleukin-18, interferon-gamma and interleukin-10 in hepatocellular carcinoma. Immunol. Lett. 2002, 84: 163–172
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