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Volume : III, Issue : II, March - 2013 THE POTENTIAL ADVANTAGES OF NANOTECHNOLOGY IN ANAPLASMOSIS THERAPEUTICS: PREPARATION OF OXYTETRACLINE-LOADED PMMA NANOPARTICLES FOR ORAL DELIVERY PRAKASH. K. B , MADHUSUDHAN. B , BHAGYALAKSHMI.M , K. DWIVEDI , JITENDER MADAN AND PRABHAKAR. P DOI : 10.9780/22307850, Published By : Laxmi Book Publication Abstract : In recent days, nanoparticles-based drug delivery systems have considerable
potential for treatment of several infectious diseases. The concept of nanoscale devices
has led to the development of biodegradable self-assembled nanoparticles being
engineered for the targeted delivery of therapeutic molecules. Biodegradable
nanoparticulate carriers have become the promising nanoscale drug delivery system.
The aim of the present investigation was to formulate and characterize the
Oxytetracycline-loaded polymeric nanoparticles. Oxytetracycline, an antianaplasmic
agent, was encapsulated by the nanoprecipitation method using poly(methyl
methacrylate). Zeetasizer, Atomic force microscope, differential scanning calorimetry
and FTIR were used to characterize the nanoparticles. The average diameters of the
nanoparticles ranged between 200-250nm and the zeta potential was -32 mV. The drug
loading capacity and loading efficiency of nanoparticles varied between 33.7% - 72.2%
and 44.5% - 76.0%. The release profiles exhibited a biphasic phenomenon indicating
controlled release of drug. The investigation suggests that the resultant nanoparticles
would promise to be a good candidate for oral administration. Keywords : Article : Cite This Article : PRAKASH. K. B , MADHUSUDHAN. B , BHAGYALAKSHMI.M , K. DWIVEDI , JITENDER MADAN AND PRABHAKAR. P, (2013). THE POTENTIAL ADVANTAGES OF NANOTECHNOLOGY IN ANAPLASMOSIS THERAPEUTICS: PREPARATION OF OXYTETRACLINE-LOADED PMMA NANOPARTICLES FOR ORAL DELIVERY. Indian Streams Research Journal, Vol. III, Issue. II, DOI : 10.9780/22307850, http://oldisrj.lbp.world/UploadedData/2154.pdf References : - Fessi, H., Puisieux, F., Devissaguet, J.P., Ammoury, N. and Benita, S. 1989. Nanocapsule formation by interfacial polymer deposition following solvent displacement. Int. J. Pharm. 55: R1–R4
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