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Volume : III, Issue : I, February - 2013 PARTICLE CHARACTERIZATION OF PRE-COMPRESSED GRANULES FOR TABLET FABRICATION USING A NOVEL PHARMACEUTICAL EXCIPIENT SEEMA PUSHKAR, NIKHIL K SACHAN, S.K. GHOSH DOI : 10.9780/22307850, Published By : Laxmi Book Publication Abstract : One of the most efficient processes for producing unit dose medication is the
compaction of pharmaceutical powder mixtures into tablets. The acceptability of tablets
formulations in the marketplace will be primarily determined by patient acceptance in a
class of equal therapeutic value. Therefore appropriate selection and use of components
that impact on these properties are of extreme importance. However, the pharmaceutical
excipients are required to comply with pharmacotechnical aptness and regulatory
qualifications desired and implemented for the purpose. Any potential formulation must
have to be financial viable simultaneously for business competiveness. In this
connection, granules fabricated with processed watermelon flesh as novel
multifunctional pharmaceutical excipient for tablet compression have been evaluated
for the pharmaceutical and micromeritic properties towards their potential use in
manufacturing of compressed tablets with identified trade merits. Evaluation of
granules was performed using drug content particle size analysis, angle of repose, bulk
and tapped density measurement, compressibility index, hausner's ratio and water
treatment. The particle size distribution was a normal distribution in all the batches. The
angle of repose of all batches depicts excellent flow of powder with added glidant which
was further supported by compressibility Index and Hausner's ratio. The results prove
the potential of formulated granules for successful compression. Keywords : Article : Cite This Article : SEEMA PUSHKAR, NIKHIL K SACHAN, S.K. GHOSH, (2013). PARTICLE CHARACTERIZATION OF PRE-COMPRESSED GRANULES FOR TABLET FABRICATION USING A NOVEL PHARMACEUTICAL EXCIPIENT. Indian Streams Research Journal, Vol. III, Issue. I, DOI : 10.9780/22307850, http://oldisrj.lbp.world/UploadedData/2022.pdf References : - Liberman, H., Lachman, Leon and Squartz, J.B. Pharmaceutical Dosage Forms : Tablets. [Ed.] 2nd. New York : Marcel Decker Publications, 2005. Vol. 1.
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