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Volume : II, Issue : XII, January - 2013 COMPARATIVE EFFECT OF ENALAPRIL AND CATOPRIL IN NORMOTENSIVE PATIENTS WITH INCIPIENT DIABETIC NEPHROPATHY R. R. SINGH , PRATAP SHANKAR , R. C. VERMA , AMODSACHAN AND R. K. DIXIT DOI : 10.9780/22307850, Published By : Laxmi Book Publication Abstract : Objective- To see the effect of enalapril and captopril on patients with diabetes and
impending diabetic nephropathy.
Material Methods- Study was performed in patients suffering with long term diabetes
mellitus. A total of 61 normotensive patients of diabetes having persistent
microproteinurea were selectedwith age >30 years, Informed consent was taken from all
patients and a strict compliance of the drugs during the study was ensured.The patients
those selected were given enalapril 2.5 mg daily or captopril 25 mg daily in two divided
doses or placebo for a period of three months.
The dietary instructions and anti-diabetic treatment at the beginning of the trial
remained unchanged during the study.
Results and Conclusion:- Both captopril and enalapril reduced protenuria significantly
as compared to the placebo group. Regarding the serum creatintine level there was no
significant alteration in both groups as compared to placebo. Keywords : Article : Cite This Article : R. R. SINGH , PRATAP SHANKAR , R. C. VERMA , AMODSACHAN AND R. K. DIXIT, (2013). COMPARATIVE EFFECT OF ENALAPRIL AND CATOPRIL IN NORMOTENSIVE PATIENTS WITH INCIPIENT DIABETIC NEPHROPATHY. Indian Streams Research Journal, Vol. II, Issue. XII, DOI : 10.9780/22307850, http://oldisrj.lbp.world/UploadedData/1853.pdf References : - Insua A, Ribstein J, Mimran A. (1988).Comparative effect of captopril and nifedipine in normotensive patients with incipient diabetic nephropathy. Postgrad Med J 64: 59-62.
- Mogensen CE, Christensen CK, Vittinghus E. (1983).The stages in diabetic renal disease. With emphasis on the stage of incipient diabetic nephropathy. Diabetes 32(2):64-78.
- Jackson B, Debrevi L, Witty M, Johnston C. (1986). Progression of renal disease: effects of different classes of antihypertensive therapy. Hypertension4 (5):269—271.
- Viberti GC, Hill RD, Jarrett RJ, Argyropoulos A, Mahmud U, Keen H (1982).Microalbuminuria as a predictor of clinical nephropathy in insulin-dependent diabetes mellitus. Lancet 1:1430 –1432
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